The effects of genetic and phenotypic production potential on response to recombinant bovine somatotropin.

Evidence was sought for an interaction between both phenotypic and genetic production potential and response of milk production to administration of bST in three trials of 38, 43, and 35 cows. In each trial, bST was administered in doses of 0, 10.3, 20.6, and, in trial 1 only, 41.2 mg/d for 38 wk from wk 4 of lactation. Data were analyzed for each experiment separately and combined across experiments. Analyses included separate regressions for treated and untreated animals for milk production during the production period on pretreatment production and estimated breeding value for milk production. Breeding value was estimated as the sire's estimated transmitting ability plus one-half of the maternal grandsire's estimated transmitting ability. With the exception of regression on estimated breeding value in trial 1 and in combined data, differences between treated and untreated animals in the regression of milk production on pretreatment milk production or on estimates of breeding value were not statistically significant. However, regressions on pretreatment production were substantially lower for treated than for untreated animals in each of the three trials. Regressions on breeding value estimated from sire and maternal grandsire estimated transmitting abilities were substantially, but not significantly, lower for untreated than for treated animals in all three trials. The results suggest that cows with high production potential for nongenetic reasons may show diminished response to bST, whereas cows with genetically high production potential show enhanced response. However, borderline statistical significance argues for considerable further examination before drawing firm conclusions.     

Interferometric interrogation of in-fiber Bragg grating sensorswithout mechanical path length scanning

We report the interrogation of a fiber Bragg grating (FBG) using an interferometer with a tilted mirror such that the optical path difference is a function of position on an array detector. Absolute measurements of mean resonant wavelength from the phase of the analytic signal of the spatial interferogram are determined, and a technique based on using a reference laser to compensate for performance degrading effects otherwise associated with spatially scanned interferometers is introduced. These measurements are not critically dependent on the accurate location of zero phase position. We have applied the technique to the absolute measurement of temperature-induced shifts in the grating resonant wavelength. A resolution of 0.025 nm for a spatially scanned optical path delay of only 200 μm was achieved. The technique has the potential for higher resolutions and for multiplexing     

A method for the selection of algorithms for form characterization of nominally spherical surfaces

This paper presents a method for the selection of algorithms for the form characterization of nominally spherical surfaces. The form characterization is applied to discrete data obtained from a three-dimensional (3-D) high-precision measurement system. In this paper, five sphere-fitting algorithms are outlined and compared. The fitting algorithms under investigation are: linear and nonlinear least-squares sphere fit, minimum zone sphere fit, four-point sphere fit, and sphere fit by error curve analysis. A method for selection of the best-fit algorithm, based on a spectral analysis of the surface irregularity is suggested and applied to the surface measurement of worn electrical switching contacts.     

Application of a mechanistic model to study competitive inhibition of amino acid uptake by the lactating bovine mammary gland

A mathematical model is used to describe uptake by a countertransport system and subsequent flow of three amino acids (AA), Phe, Val, and Met, from arterial blood to milk protein in the mammary gland of a lactating cow. The model suggests that total uptake of all AA is higher than net uptake and that a large proportion of the incoming AA is released from the cell directly back to blood. The model is used to predict which of the three AA is limiting the rate of milk protein synthesis and the response to increased arterial concentration of the first-limiting AA. Simulations are performed to predict possible outcomes of several experimental protocols to AA infusion, which might be used to test in vivo the responsiveness of the bovine mammary gland to an altered arterial concentration of AA. Of the three AA considered, arterial Met concentration appears to be first-limiting. The infusion profile that gives the greatest response in milk protein synthesis rate alters the arterial profile of AA such that it is identical to that of proteins originating in the mammary gland. Model construction can be simplified by acknowledging normal biological constraints.     

Mitral valve replacement: randomized trial of St. Jude and Medtronic Hall prostheses

BACKGROUND: This study was designed to better define the merits of the bileaflet and tilting-disc valves. METHODS: We prospectively randomized 156 patients (mean age, 59 years) to receive either the St. Jude (n = 80) or the Medtronic Hall (n = 76) mitral valve prosthesis between September 1986 and December 1997. The two groups were not significantly different with respect to preoperative New York Heart Association class, left ventricular ejection fraction, incidence of mitral stenosis or insufficiency, extent of coronary artery disease, completeness of revascularization, or cross-clamp or bypass time. RESULTS: The operative mortality (11.2% versus 13.1%, St. Jude versus Medtronic Hall, respectively) and late mortality (27% versus 22%, St. Jude versus Medtronic Hall, respectively) were not significantly different. Follow-up was complete in all hospital survivors with a mean of 60.7 months (range, 1 to 133 months). The analysis of 10-year actuarial survival and freedom from valve-related events demonstrated no significant differences between the cohorts. Freedom from reoperation was higher in the St. Jude group (p < 0.01). Comparisons of patient functional status and echocardiographic hemodynamic parameters obtained at the time of follow-up demonstrated no significant differences between the two prostheses. CONCLUSIONS: This study suggests that there is no difference between the St. Jude and Medtronic Hall prostheses with respect to late clinical performance or hemodynamic results and therefore does not support the preferential selection of either prosthesis.     

The rise and fall of an executive information system: a case study

The progress of an executive information system project within a manufacturing organization over a period of 9 years is described. The case study illustrates the importance of the interaction between the business environment, the organizational environment and the perceptions and interpretations of events and facts by stakeholders on the success or failure of an information system. It shows the importance of context in the development and implementation of an executive information system and the dynamic nature of the influence of social, economic and technical factors. The reasons for the initial success and the subsequent failure of the EIS within the company are explored from a contingency perspective.     

Safety implications of control systems

As part of an overall program to determine the extent to which failures of control can impact plant safety, control failures in the Oconee-1 nuclear plant were examined. Plant systems capable of initiating plant overcooling and undercooling were identified, as well as those with potential for overfilling events in the steam generators. Failure mode and effects analyses (FMEA) were conducted on these candidate plant systems, with computer analysis applied where appropriate. This latter process utilized a detailed hybrid computer model of Oconee-1, developed as part of this program. Where failures with safety consequences were found, probabilities of the pertinent scenarios were developed. Tentative recommendations for corrective actions have been sought.     

Rumination and psychological distress among bereaved partners.

Recently bereaved men who evidenced more negative ruminative thoughts in free-response interviews showed greater psychological distress on several outcome measures both 1 month and 12 months after their loss and less increase in positive morale over this 12-month period. Men who engaged in more analysis of themselves and the meaning of their loss reported greater positive morale 1 month after their loss but showed more persistent depression and absence of positive states of mind over the 12 months following their loss. Finally, men who reported more social friction also evidenced more enduring depressive symptoms over the year than did men who reported less social friction. These results are generally consistent with other studies that have shown that self-reflective, ruminative coping with negative emotions and social friction are associated with longer and more severe periods of depressed mood following stressful events. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The energetics of gas flow and contact erosion during short circuit arcing

The processes governing the movement of short circuit arcs in circuit breakers are complex and variable and the detailed understanding of these processes is incomplete. This paper presents a new approach to our understanding of the short circuit arcing process by concentrating on the bulk thermal behavior and energetics of the arcing and gas flow during contact opening. It is shown how considerations of the arc power and the heating and vaporization of the contact material can be used to examine the flow of gas through the arc chamber and the erosion of contact material. Experimental data from a flexible test apparatus and arc imaging system along with measurements of pressure and arc current and voltage are used as the basis of the analysis. It is demonstrated how the air initially present in the arc chamber will be rapidly expelled from the arc chamber to leave an arc burning in the products of contact volatilization. Data on mass and volume flow rates are presented as well as estimates of the gas velocity in the contact region. These data provide information on the nature of the gas flow in the arc chamber as well as contact erosion during the arcing process. Arcing conditions of interest are short circuit faults (10/sup 3/-10/sup 4/ A) in low voltage (220-380 VAC) circuit breakers.