Rheological Foundations of Powder Consolidation Processes and the “Mean-Square” Concept

The past, present, and possible future development of basic models for engineering processes in powder metallurgy are examined. Special attention is devoted to the rheological concept of sintering and strain, as well as to the “mean-square” concept which together form the ideological basis for many existing models. Modern generalizations of sintering models to the cases of anisotropy and phase transitions in the matrix material are examined. Models of plastic and nonlinearly viscous flows that follow from the “mean-square concept” concept are correlated with other theories of flow in porous media. The relationship among these is established. The possible use of these ideas for solving current problems in materials science is discussed.     

Mode II Macrocrack Initiation in Orthotropic Composite Viscoelastic Plate

Safe loads and initiation time for a straight macrocrack in viscoelastic orthotropic material that is intended to model a fiber composite plate under shear loads is investigated. The composite material is modeled by viscoelastic orthotropic medium. Determination of expression for crack shear displacement as function of time is based on the corresponding elastic solution and the method of operator continued fractions. Initiation time is obtained as a solution of integral equation for the incubation period. Numerical calculations are given for mode II macrocrack initiation.     

A Procedure for Measuring Mass Flow Rate Using Critical Nozzles

A new approach to measuring mass flow rate using critical nozzles is proposed. The novelty of the approach lies in the fact that the laws of conservation (of mass, energy and momentum) in the one-dimensional gas flow are matched and the dependence of the thermal characteristics of an actual gas (the adiabatic exponent and the compressibility) on the static pressure and the temperature in the gas flow is taken into account. The VNIIMS procedure and algorithm are presented and are illustrated using a specific example.     

Unifying stabilization and termination in message-passing systems

The paper dispels the myth that it is impossible for a message-passing program to be both terminating and stabilizing. We consider a rather general notion of termination: a terminating program eventually stops its execution after the environment ceases to provide input. We identify termination-symmetry to be a necessary condition for a problem to admit a solution with such properties. Our results do confirm that a number of well-known problems (e.g., consensus, leader election) do not allow a terminating and stabilizing solution. On the flip side, they show that other problems such as mutual exclusion and reliable-transmission allow such solutions. We present a message-passing solution to the mutual exclusion problem that is both stabilizing and terminating. We also describe an approach of adding termination to a stabilizing program. To illustrate this approach, we add termination to a stabilizing solution for the reliable transmission problem.Published online: 15 November 2004Anish Arora: Supported in part by DARPA contract OSU-RF #F33615-01-C-1901,NSF grant NSF-CCR-9972368, Ohio State University Fellowship,and 2002-2003,2003-2004 grants from Microsoft Research.Mikhail Nesterenko: Supported in part by DARPA contract OSU-RF #F33615-01-C-1901 and byNSF CAREER Award 0347485Some of the results in this paper were presented at the 21st International Conference on Distributed Computing Systems, Mesa, Arizona, April 2001, pp 99-106. Correspondence to: Mikhail Nesterenko     

Decay of Supercurrents in Condensates in Optical Lattices

In this paper we discuss decay of superfluid currents in boson lattice systems due to quantum tunneling and thermal activation mechanisms. We derive asymptotic expressions for the decay rate near the critical current in two regimes, deep in the superfluid phase and close to the superfluid-Mott insulator transition. The broadening of the transition at the critical current due to these decay mechanisms is more pronounced at lower dimensions. We also find that the crossover temperature below which quantum decay dominates is experimentally accessible in most cases. Finally, we discuss the dynamics of the current decay and point out the difference between low and high currents.     

Novel Very Long-Chain α-Methoxylated Δ5,9 Fatty Acids from the Sponge Asteropus niger Are Effective Inhibitors of Topoisomerases IB

The novel fatty acids (2R,5Z,9Z)‐2‐methoxy‐25‐methyl‐5,9‐hexacosadienoic acid ( 1a ) and (2R,5Z,9Z)‐2‐methoxy‐24‐methyl‐5,9‐hexacosadienoic acid ( 1b ) were isolated in 80 % purity from the Caribbean sponge Asteropus niger by chloroform/methanol extraction followed by solvent partitioning and silica gel column chromatography. The compounds were characterized by utilizing a combination of gas chromatography‐mass spectrometry, nuclear magnetic resonance, and circular dichroism. Acids 1a and 1b were not detected in the phospholipids (PtdCho and PtdIns) of the sponge, but rather as free FA and possibly in glycosylceramides. The mixtures of 1a and 1b displayed cytotoxicity towards THP‐1 and HepG2 cells with EC_50's between 41 and 35 μg/mL. Apoptosis was not the preferred mode of cell death induced by 1a – 1b in the THP‐1 cells. This implies other types of cytotoxicity mechanisms, such as membrane disruption and/or the inhibition (EC₅₀ = 1.8 μg/mL) of the human topoisomerase IB enzyme (hTopIB), with a mechanism of inhibition different from the one displayed by camptothecin (CPT). In a separate experiment, the mixture of 1a and 1b also displayed cytotoxicity towards ex vivo mouse splenocytes infected with Leishmania infantum amastigotes (IC₅₀ = 0.17 mg/mL) and free living promastigotes (IC₅₀ = 0.34 mg/mL). It was also found that the FA were inhibitory of the Leishmania topoisomerase IB (LTopIB) with an EC₅₀ = 5.1 μg/mL. Taken together, 1a and 1b represent a new class of FA with potential as TopIB inhibitors that preferentially inhibit hTopIB over LTopIB.     

Insulating characteristics of zinc niobium borate glass‐ceramics

Zinc borate glasses with different concentrations of Nb₂O₅ were prepared and later were heat treated for prolonged times. Prepared samples were characterized by XRD, SEM, DSC, IR and optical transmission spectroscopy techniques. Later, dielectric properties viz., dielectric constant, loss tangent, electric modulii, electrical impedance and a.c. conductivity over wide ranges of frequency and temperature, were investigated as a function of Nb₂O₅ concentration. Finally, the dielectric breakdown strength was measured in air medium at ambient temperature. The results of characterization techniques viz., XRD, SEM and DSC indicated that multiple crystal grains (with sizes varying from 0.1 to 1 μm) are dispersed in the residual glass phase. The concentration of crystal grains found to increase with increase in Nb₂O₅ content. The XRD studies have further revealed that the bulk samples are composed of columbite ZnNb₂O₆ crystal phases. Using generalized gradient approximation (GGA) quantitative information on these crystal phases viz., the lattice parameters, optical band gap and band structure were evaluated. The analysis of results of IR spectral studies have indicated that there is an increasing degree of polymerization of glass network with increase in Nb₂O₅ content due to the increased connectivity between various structural groups in the glass network. The optical absorption spectra indicated an increase in optical transmittance of the bulk samples with increase in Nb₂O₅ content. The dielectric parameters are observed to decrease, whereas the dielectric breakdown strength is observed to increase to a large extent due to the crystallization of the glass with the Nb₂O₅. The increase is attributed to the formation of ZnNb₂O₆ crystalline phases that contain intertwined ZnO₆ and NbO₆ structural units. As a whole, zinc borate glasses exhibited a significant increase in the electrical insulating strength due to the crystallization with Nb₂O₅ as the crystallizing agent. Further, the value of dielectric constant is also found to be the optimal with no dispersion with frequency up to 450 K. Overall, the studied glass‐ceramics meet the necessary physical conditions to be used as insulating layers in the display panels and hence may be considered for such applications.     

Dynamic mechanical analysis of ethylene/1‐hexene copolymers: The effect of the catalyst type on the short‐chain branching distribution and properties of the amorphous and crystalline phases

Dynamic mechanical analysis was used to study ethylene/1‐hexene copolymers with different compositions, molecular weight distributions, and profiles of short‐chain branching (SCB) versus molecular weight. These copolymers were produced over a highly active supported titanium–magnesium catalyst (TMC), a highly active supported vanadium–magnesium catalysts (VMC), and a supported zirconocene catalyst. A higher fraction of the crystalline phase in the copolymers prepared with VMC was shown to result in higher elastic modulus values. β relaxation was found to be sensitive to the SCB distribution versus the molecular weight. The copolymers prepared with the zirconocene catalyst and VMC were characterized by more uniform SCB distributions and higher temperatures of β relaxation compared to the copolymers prepared with TMC. The mobility of the polymer chains at room temperature in the amorphous phase obtained by the spin‐probe method rose with increasing branch content in the copolymers and was not sensitive to different SCB distribution profiles. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134, 44638.     

Elimination of systematic mass measurement errors in liquid chromatography-mass spectrometry based proteomics using regression models and a priori partial knowledge of the sample content

The high mass measurement accuracy and precision available with recently developed mass spectrometers is increasingly used in proteomics analyses to confidently identify tryptic peptides from complex mixtures of proteins, as well as post-translational modifications and peptides from nonannotated proteins. To take full advantage of high mass measurement accuracy instruments, it is necessary to limit systematic mass measurement errors. It is well known that errors in m/z measurements can be affected by experimental parameters that include, for example, outdated calibration coefficients, ion intensity, and temperature changes during the measurement. Traditionally, these variations have been corrected through the use of internal calibrants (well-characterized standards introduced with the sample being analyzed). In this paper, we describe an alternative approach where the calibration is provided through the use of a priori knowledge of the sample being analyzed. Such an approach has previously been demonstrated based on the dependence of systematic error on m/z alone. To incorporate additional explanatory variables, we employed multidimensional, nonparametric regression models, which were evaluated using several commercially available instruments. The applied approach is shown to remove any noticeable biases from the overall mass measurement errors and decreases the overall standard deviation of the mass measurement error distribution by 1.2-2-fold, depending on instrument type. Subsequent reduction of the random errors based on multiple measurements over consecutive spectra further improves accuracy and results in an overall decrease of the standard deviation by 1.8-3.7-fold. This new procedure will decrease the false discovery rates for peptide identifications using high-accuracy mass measurements.     

Pseudorandom sequence modifications for ion mobility orthogonal time-of-flight mass spectrometry

Due to the inherently low duty cycle of ion mobility spectrometry (IMS) experiments that sample from continuous ion sources, a range of experimental advances have been developed to maximize ion utilization efficiency. The use of ion trapping and accumulation approaches prior to the ion mobility drift tube has demonstrated significant gains over discrete sampling from continuous sources but have traditionally relied upon a signal averaging (SA) to attain analytically useful signal-to-noise ratios (SNR). Multiplexed (MP) techniques based upon the Hadamard transform offer an alternative experimental approach by which ion utilization efficiency can be elevated from approximately 1 to approximately 50%. Recently, our research group demonstrated a unique multiplexed ion mobility time-of-flight (MP-IMS-TOF) approach that incorporates ion trapping and can extend ion utilization efficiency beyond 50%. However, the spectral reconstruction of the multiplexed signal using this experiment approach requires the use of sample-specific weighting designs. Such general weighting designs have been shown to significantly enhance ion utilization efficiency using this MP technique, but cannot be universally applied. By modifying both the ion trapping and the pseudorandom sequence (PRS) used for the MP experiment, we have eliminated the need for complex weighting matrices. For both simple and complex mixtures, SNR enhancements of up to 13 were routinely observed as compared to the SA-IMS-TOF approach. In addition, this new class of PRS provides a 2-fold enhancement in the number of ion gate pulses per unit time compared to the traditional HT-IMS experiment.