数学分离-多波长直线回归法测定鼻炎滴剂中的黄芩苷和盐酸麻黄碱

鼻炎滴剂是中西复方制剂,主要成分有黄芩苷、盐酸麻黄碱、金银花、辛夷油、冰片等.本文研究建立了数学分离-多波长直线回归法,用于测定鼻炎滴剂中黄芩苷和盐酸麻黄碱的含量.黄芩苷和盐酸麻黄碱的最大吸收波长分别为278.0 nm和257.0 nm,将2组分吸收强度较大的242.0 nm～283.0 nm选为测定范围.在测定范围内选择42个点进行测定,使用数学分离-多波长直线回归方法计算分析,直接测定了鼻炎滴剂中的黄芩苷和盐酸麻黄碱含量.本文研究使用的市售鼻炎滴剂中2种药效成分的平均回收率和相对标准偏差分别为102.0％,0.86％和98.2％,0.87％.数学分离-多波长直线回归法简单、快速、准确、适用于鼻炎滴剂的质量控制过程.     

An efficient state space generation for the analysis of real-timesystems

State explosion is a well-known problem that impedes analysis and testing based on state-space exploration. This problem is particularly serious in real time systems because unbounded time values cause the state space to be infinite even for simple systems. The author presents an algorithm that produces a compact representation of the reachable state space of a real time system. The algorithm yields a small state space, but still retains enough information for analysis. To avoid the state explosion which can be caused by simply adding time values to states, our algorithm uses history equivalence and transition bisimulation to collapse states into equivalent classes. Through history equivalence, states are merged into an equivalence class with the same untimed executions up to the states. Using transition bisimulation, the states that have the same future behaviors are further collapsed. The resultant state space is finite and can be used to analyze real time properties. To show the effectiveness of our algorithm, we have implemented the algorithm and have analyzed several example applications     

一种基于聚类的空间数据知识获取算法

本文提出了一个针对空间数据库基于聚类的知识获得取算法,该算法可解决空间的数据的聚类问题。     

大型复杂仿真系统相似性模糊综合评判

利用模糊数学对仿真模型进行相似性检验,提出了定量与定性相结合、主观与客观相结合的仿真模型与实现模型相似性模糊综合评判法,并给出了各种实用算法和适用场合,对处理“黑盒”和“灰盒”的仿真模型检验具有参考价值。     

A Compact Fourth-Order Finite Difference Scheme for Unsteady Viscous Incompressible Flows

In this paper, we extend a previous work on a compact scheme for the steady Navier–Stokes equations [Li, Tang, and Fornberg (1995), Int. J. Numer. Methods Fluids, 20, 1137–1151] to the unsteady case. By exploiting the coupling relation between the streamfunction and vorticity equations, the Navier–Stokes equations are discretized in space within a 3×3 stencil such that a fourth order accuracy is achieved. The time derivatives are discretized in such a way as to maintain the compactness of the stencil. We explore several known time-stepping approaches including second-order BDF method, fourth-order BDF method and the Crank–Nicolson method. Numerical solutions are obtained for the driven cavity problem and are compared with solutions available in the literature. For large values of the Reynolds number, it is found that high-order time discretizations outperform the low-order ones.     

高速公路联网系统车道收费软件的设计与实现

通过对当前常用的车道收费软件的分析对比,提出了一种基于Mini Server战术的车道收费软件的体系结构,并就其实现技术及性能特点进行了详细的论述,还对Mini Server控制下多Agent通信策略等方面进行了较深入的描述。     

Neuroproteomics and its applications in research on nicotine and other drugs of abuse

The rapidly growing field of neuroproteomics is able to track changes in protein expression and protein modifications underlying various physiological conditions, including the neural diseases related to drug addiction. Thus, it presents great promise in characterizing protein function, biochemical pathways, and networks to understand the mechanisms underlying drug dependence. In this article, we first provide an overview of proteomics technologies and bioinformatics tools available to analyze proteomics data. Then we summarize the recent applications of proteomics to profile the protein expression pattern in animal or human brain tissues after the administration of nicotine, alcohol, amphetamine, butorphanol, cocaine, and morphine. By comparing the protein expression profiles in response to chronic nicotine exposure with those appearing in response to treatment with other drugs of abuse, we identified three biological processes that appears to be regulated by multiple drugs of abuse: energy metabolism, oxidative stress response, and protein degradation and modification. Such similarity indicates that despite the obvious differences among their chemical properties and the receptors with which they interact, different substances of abuse may cause some similar changes in cellular activities and biological processes in neurons.     

Transient temperature responses of hydronic radiant floor heating system by different pipe embedding depth and water supply condition

"Ondol" is a Korean unique heating system. It is a specific radiant floor heating system using combustion heat of briquette or timber in Korea. Such traditional "Ondol" is changed to radiant heating system with pipe-coil embedded in the floor or slab. This study has contributed to the understandings of the transient behaviours of Ondol-heated floor panels and enclosure exposed to this type of heating system. The result is that the water supply temperature had a large effect on the rate of increase in floor surface and room air temperature. But, in spite of a higher water supply temperature, the heat flow rate was not increased considerably. The shallow pipe embedding depths, of course, result in a low heat flow rate.     

彗星试验在农药安全评价中的应用

彗星试验(Comet assay)，又称单细胞凝胶电泳试验(SCGE)，是一种快速、简便、灵敏的检测单个细胞DNA断裂的新技术，由于其具备其它试验无可比拟的优越性，因此应用前景十分广泛。本文就该技术的原理、操作程序和方法作一介绍，并预测其在农药安全评价中将有广阔的应用前景。