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排序方式: 共有897条查询结果,搜索用时 15 毫秒
31.
Sridhar Ungarala 《Journal of Process Control》2012,22(5):935-943
The extended Kalman filter (EKF) is a suboptimal estimator of the conditional mean and covariance for nonlinear state estimation. It is based on first order Taylor series approximation of nonlinear state functions. The unscented Kalman filter (UKF) and the ensemble Kalman filter (EnKF) are suboptimal estimators that are termed as Jacobian free because they do not require the existence of the Jacobian of the nonlinearity. The iterated form of EKF is an estimator of the conditional mode that employs an approximate Newton–Raphson iterative scheme to solve the maximization of the conditional probability density function. In this paper, the iterated forms of UKF and EnKF are presented that perform Newton–Raphson iteration without explicitly differentiating the nonlinear functions. The use of statistical linearization in iterated UKF and EnKF is a nondifferentiable optimization method when the measurement function is nonsmooth or discontinuous. All three iterated forms can be shown to be conditional mean estimators after the first iteration. A simple numerical example involving continuous and discontinuous measurment functions is included to evaluate the performance of the algorithms for the estimation of conditional mean, covariance and mode. A batch reactor simulation is shown for estimating both the states and unknown parameters. 相似文献
32.
Ch. R. V. S. Nagesh Ch. Sridhar Rao N. B. Ballal P. Krishna Rao 《Metallurgical and Materials Transactions B》2004,35(1):65-74
The Kroll process of magnesium reduction of titanium tetrachloride is used the world over the production of titanium metal
in the form of sponge. Although the process has been in practice for the last five decades, there is no clear understanding
of the reaction mechanism and sponge formation. The present study involved reduction experiments in a 2000 kg titanium sponge-capacity
prototype reactor to develop a better understanding of TiCl4 reduction of magnesium with respect to the process parameters. Experiments were also conducted in two smaller experimental
reactors to study the temperature evolution during the process as a function of the TiCl4 feed rate. Based on the results of all these experiments, a model has been proposed for the mechanism of sponge formation
in the Kroll process. 相似文献
33.
We explore tradeoffs between organization and number of ALUs and clock frequency in a stream processor. The tool provides candidate low-power configurations and estimates of their real-time performance. The tool relates instruction-level, subword, and data parallelism to functional units' organization and utilization. The exploration methodology is applicable to all embedded-processor designs in signal and media processing. 相似文献
34.
Mixture Effects of Tryptophan Intestinal Microbial Metabolites on Aryl Hydrocarbon Receptor Activity
Aneta Vrzalov Petra Pe
inkov Peter Ills Soa Gursk Petr Dubk Martin Szotkowski Marin Hajdúch Sridhar Mani Zdenk Dvok 《International journal of molecular sciences》2022,23(18)
Aryl hydrocarbon receptor (AHR) plays pivotal roles in intestinal physiology and pathophysiology. Intestinal AHR is activated by numerous dietary, endogenous, and microbial ligands. Whereas the effects of individual compounds on AHR are mostly known, the effects of real physiological mixtures occurring in the intestine have not been studied. Using reporter gene assays and RT-PCR, we evaluated the combinatorial effects (3520 combinations) of 11 microbial catabolites of tryptophan (MICTs) on AHR. We robustly (n = 30) determined the potencies and relative efficacies of single MICTs. Synergistic effects of MICT binary mixtures were observed between low- or medium-efficacy agonists, in particular for combinations of indole-3-propionate and indole-3-lactate. Combinations comprising highly efficacious agonists such as indole-3-pyruvate displayed rather antagonist effects, caused by saturation of the assay response. These synergistic effects were confirmed by RT-PCR as CYP1A1 mRNA expression. We also tested mimic multicomponent and binary mixtures of MICTs, prepared based on the metabolomic analyses of human feces and colonoscopy aspirates, respectively. In this case, AHR responsiveness did not correlate with type of diet or health status, and the indole concentrations in the mixtures were determinative of gross AHR activity. Future systematic research on the synergistic activation of AHR by microbial metabolites and other ligands is needed. 相似文献
35.
Graph structure in the Web 总被引:11,自引:0,他引:11
Andrei Broder Ravi Kumar Farzin Maghoul Prabhakar Raghavan Sridhar Rajagopalan Raymie Stata Andrew Tomkins Janet Wiener 《Computer Networks》2000,33(1-6)
The study of the Web as a graph is not only fascinating in its own right, but also yields valuable insight into Web algorithms for crawling, searching and community discovery, and the sociological phenomena which characterize its evolution. We report on experiments on local and global properties of the Web graph using two AltaVista crawls each with over 200 million pages and 1.5 billion links. Our study indicates that the macroscopic structure of the Web is considerably more intricate than suggested by earlier experiments on a smaller scale. 相似文献
36.
Sandeep Peddi Rapur Ram Varalakshmi Devi Boreddy Sridhar Avssn Krishna Kishore Chennu Siva Kumar Vishnubotla 《Hemodialysis international. International Symposium on Home Hemodialysis》2014,18(1):192-194
We present an end‐stage renal disease patient on dialysis with fever. The primary source was right internal jugular vein catheter which had metastatic infections in the body probably via an arteriovenous communication in a cavity in left lung. Patient had right psoas muscle abscess and a left kidney abscess. An 18F‐fluorodeoxyglucose‐positron emission spectroscopy scan was done to find out left kidney abscess. A search of literature did not reveal many patients of psoas abscess secondary to infection of hemodialysis access. 相似文献
37.
Indika Dissanayake Jie Zhang Mahmut Yasar Sridhar P. Nerur 《Information & Management》2018,55(3):396-406
Online innovation tournaments, such as those hosted by crowdsourcing platforms (e.g., Kaggle), have been widely adopted by firms to evolve creative solutions to various problems. Solvers compete in these tournaments to earn rewards. In such competitive environments, it is imperative that solvers provide creative solutions with minimum effort. This article explores the factors that influence the solvers’ effort allocation decisions in a dynamic tournament setting. Specifically, comprehensive time variant data of teams that participated in crowdsourcing competitions on Kaggle were analyzed to gain insight into how solvers continually formulate strategies in light of performance feedback obtained through interim ranking. The results suggest that solvers strategically allocate their efforts throughout the contest to dynamically optimize their payoffs through balancing the probability of winning and the cost of expending effort. In particular, solvers tend to increase their efforts toward the end of tournaments or when they get closer to winning positions. Furthermore, our findings indicate that a last-minute surge in effort is more prevalent among high-skill solvers than in those with lower skill levels. In addition to providing insights that may help solvers develop strategies to improve their performance, the study has implications for the design of online crowdsourcing platforms, particularly in terms of incentivizing solvers to put forth their best effort. 相似文献
38.
Susanna K. P. Lau Kim-Chung Lee George C. S. Lo Vanessa S. Y. Ding Wang-Ngai Chow Tony Y. H. Ke Shirly O. T. Curreem Kelvin K. W. To Deborah T. Y. Ho Siddharth Sridhar Sally C. Y. Wong Jasper F. W. Chan Ivan F. N. Hung Kong-Hung Sze Ching-Wan Lam Kwok-Yung Yuen Patrick C. Y. Woo 《International journal of molecular sciences》2016,17(3)
To identify potential biomarkers for improving diagnosis of melioidosis, we compared plasma metabolome profiles of melioidosis patients compared to patients with other bacteremia and controls without active infection, using ultra-high-performance liquid chromatography-electrospray ionization-quadruple time-of-flight mass spectrometry. Principal component analysis (PCA) showed that the metabolomic profiles of melioidosis patients are distinguishable from bacteremia patients and controls. Using multivariate and univariate analysis, 12 significant metabolites from four lipid classes, acylcarnitine (n = 6), lysophosphatidylethanolamine (LysoPE) (n = 3), sphingomyelins (SM) (n = 2) and phosphatidylcholine (PC) (n = 1), with significantly higher levels in melioidosis patients than bacteremia patients and controls, were identified. Ten of the 12 metabolites showed area-under-receiver operating characteristic curve (AUC) >0.80 when compared both between melioidosis and bacteremia patients, and between melioidosis patients and controls. SM(d18:2/16:0) possessed the largest AUC when compared, both between melioidosis and bacteremia patients (AUC 0.998, sensitivity 100% and specificity 91.7%), and between melioidosis patients and controls (AUC 1.000, sensitivity 96.7% and specificity 100%). Our results indicate that metabolome profiling might serve as a promising approach for diagnosis of melioidosis using patient plasma, with SM(d18:2/16:0) representing a potential biomarker. Since the 12 metabolites were related to various pathways for energy and lipid metabolism, further studies may reveal their possible role in the pathogenesis and host response in melioidosis. 相似文献
39.
40.
Venkataraman Ganesh Perali Ramu Sridhar Srinivasan Chandrasekaran 《Israel journal of chemistry》2016,56(6-7):417-430
In this account, we elaborate our group's contribution towards understanding the chemistry of carbohydrate-derived donor-acceptor (DA) cyclopropanes. Our work was mainly focused on the ring opening of these versatile chiral synthons under the influence of Lewis acid promoters like electrophilic halogen species, TMSOTf, BF3.OEt2, etc. We studied various modes of ring opening on these DA cyclopropanes, envisaging the access to intriguing molecular architectures. These modes of reaction of the DA cyclopropanes can be controlled by strategically introducing an electron-withdrawing group (EWG) onto the cyclopropane ring, which could direct the ring cleavage by polarizing the cyclopropane C−C bond. Our studies also revealed that the ring opening is sluggish in the absence of an EWG. Using this concept, we demonstrated the synthesis of various biologically interesting molecular skeletons, viz., glycoamino acids (GAA), GAA nucleotides, α-levoglucosan amino acid, and septano-oligosaccharides, with high selectivity. We also applied our understanding to the first stereoselective synthesis of (S)-(−)-longianone and confirmed its absolute configuration. Apart from the inherently activated DA cyclopropanes, we introduced the in situ generation of DA cyclopropanes, starting from vinylcyclopropanes (VCPs). The ring-opening and ring-expansion chemistry of these easily accessible synthons was studied. The chemistry developed for carbohydrate-fused cyclopropanes was also applied for carbohydrate-derived spiro-cyclopropanes. The Lewis-acid-mediated ring opening of spiro-DA-cyclopropanes enabled easy access to fused furopyrans and spirolactones. 相似文献