Automatic verification of reduction techniques in Higher Order Logic

In this paper we propose an automatic methodology to verify the soundness of model checking reduction techniques. The idea is to use the consistency of the specifications to verify if the reduced model is faithful to the original one. The user provides the reduction technique, the specification and the system under verification. Then, using Higher Order Logic he verifies automatically if the reduction technique is soundly applied. The method is completely defined in an MDG–HOL special integration platform that combines an automatic high level model checking tool Multiway Decision Graphs (MDGs) within the HOL theorem prover. We provide two case studies, the first one is the reduction using SAT–MDG of an Island Tunnel Controller and the second one is the MDG–HOL assume-guarantee reduction of the Look-Aside Interface. The obtained results of our approach offer a considerable gain in terms of the correctness of heuristics and reduction techniques as applied to commercial model checking, however a small penalty is paid in terms of CPU time and memory usage.     

Natural convection from isothermal flat surfaces

Local heat-transfer coefficients along a flat plate in natural convection in air were measured using Boelter-Schmidt type heat flux meters. Experiments were carried out for different temperature differences in heating and cooling, and with inclinations varying from the horizontal “facing upwards” position, through the vertical position, to the horizontal “facing downwards” position.

The results are presented in terms of local Nusselt number as a function of the local Grashof number “tangential component”. All runs were in the range accepted as that of laminar boundary layer flow. However, under certain conditions when the normal velocity component of the air is directed away from the surface, separated flow is indicated along the trailing part of the surface, well before turbulence sets in in the boundary layer. Separation starts at a certain point along the surface. This point is nearer to the leading edge the higher the temperature difference, and the larger the inclination of the surface to the vertical.

In a separation region, the flux density is uniform. In all other regions the results agreed closely with established theories of laminar boundary layer flow.

A leading adiabatic section, used in some of the experiments, did not affect the results. An appendix gives relations recommended for engineering calculations.     

Robust design of processes and products using the mathematics of the stochastic frontier (SF)

The International Journal of Advanced Manufacturing Technology - The paper discusses a generic procedure for the parameter design of product and process development using planned and non-planned...     

Synthesis and Anti-Cancer Activity of New Pyrazolinyl-Indole Derivatives: Pharmacophoric Interactions and Docking Studies for Identifying New EGFR Inhibitors

Newly designed series of indole-containing pyrazole analogs, pyrazolinylindoles, were synthesized, and their structures were confirmed based on the spectral data of the ¹H NMR, ¹³C NMR, and HR-MS analyses. Preliminary anti-cancer activity testings were carried out by the National Cancer Institute, United States of America (NCI, USA). Compounds HD02, HD05, and HD12 demonstrated remarkable cytotoxic activities against nine categories of cancer types based cell line panels which included leukemia, colon, breast, melanoma, lungs, renal, prostate, CNS, and ovarian cancer cell lines. The highest cytotoxic effects were exhibited by the compounds HD02 [1-(5-(1-H-indol-3-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-phenylethanone], HD05 [1-(3-(4-chlorophenyl)-5-(1H-indol-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)-2-phenoxyethanone], and HD12 [(3-(4-chlorophenyl)-5-(1H-indol-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-4-yl)methanone] against some of the 56 types of NCI-based cell lines in different panels. Compound HD05 showed the maximum range of cancer cell growth inhibitions against all categories of the cell lines in all nine panels. On average, in comparison to the referral standard, imatinib, at a dose level of 10 µM, the HD05 showed significant activity against leukemia in the range of 78.76%, as compared to the imatinib at 9% of cancer cells’ growth inhibitions. Molecular docking simulation studies were performed in silico on the epidermal growth factor receptor (EGFR) tyrosine kinase, in order to validate the activity.     

Reactions with Thiazolo[3,2-b]-s-triazol-3(2H)-ones

5-Aryl-3-carboxymethylthio-1,2,4-triazoles 2 are cyclised to 6-arylthiazolo[3,2-b]-s-triazol-3(2H)-ones 3 . This structural assignment has been based on IR and NMR spectra. 2-Arylmethylene-6-arylthiazolo[3,2-b]-s-triazol-3(2H)-ones 7 were prepared by several methods. Compounds 3 coupled with diazotised anilines to give 2,3-dihydro-6-arylthiazolo[3,2-b]-s-triazole-2,3-dione 2-arylhydrazones 8 . The action of amines on 3a opens the thiazolone ring with the formation of substituted (5-phenyltriazol-3-ylthio)-acetamides 9 .     

Simulation of the urban climate variations in connection with the transformations of the city of Nantes since the 17th century

The paper seeks to quantify the effect of urban politics on the microclimate of the city of Nantes (France), in particular those initiated by the sanitarians in the mid-19th century to find a remedy for the insalubrity that had been developing with urban densification since the late 17th century. Intensive historical research was first carried out in order to define and date the major transformations undergone by the city, its structure (densification, then widening of the streets, filling of water courses), the lifestyle habits (heating) or the building practices (appearance of stone and paving, higher buildings, insulation). This led to the definition of 5 characteristic states of the city, in 1680, 1756, 1835, 1880 and 1945.     

Turbulent boundary layers: is the wall falling or merely wobbling?

A quick passage through five centuries of turbulence research highlights the major milestones. The more recent cornerstones include Kolmogorov??s equilibrium theory of turbulence spectrum, the universal logarithmic law of wall-bounded flows, and the proliferation of direct numerical simulations. Evidence of recent fault lines in all three major achievements is presented, but also novel remedies as well as a few contemporary accomplishments are pointed out.