Kinetic analysis of plasma VLDL-TG and VLDL-remnant-TG turnover in anesthetized rats

We have estimated the turnover and relative pool sizes of nascent-VLDL-TG and VLDL-remnants-TG in anesthetized rats. [1-¹⁴C]Palmitoyl- and [2-³H]glyceryl-labeled “VLDL”-TG (including nascent VLDL-TG and VLDL-remnants-TG) were prepared by injecting labeled palmitate and glycerol into donor rats. Labeled serum from these rats was then injected intravenously into nembutalized male rats and serial blood samples taken for 30 min. Special care was taken to define any early components in the labeled “VLDL”-TG disappearance curves. In other experiments, the donors were rendered functionally hepatectomized 30 min after injection of³H-glycerol and the endogenous labeled VLDL-TG was allowed to circulate 30–60 min before collection of the TG-labeled VLDL-remnants-containing serum. The latter was injected into 4 recipient nembutalized rats and the remnant-TG-turnover measured by serial sampling as above. In two cases,¹⁴C-“VLDL” and³H-VLDL-remnants were injected as a single bolus into ether-anesthetized rats. Despite its complex composition, “VLDL”-TG in most cases disappeared in a single exponential fashion for 30 min with an average half-life of 5.9 min in nembutalized and 2.8 in ether-anesthetized rats. VLDL-remnants-TG showed a more complex behavior, but contained a major rapid component with a mean t_1/2 of ca. 1.5 min in both groups. The data, analyzed by multicompartmental analysis, were fitted to a simple model in which turnover of a larger nascent VLDL-TG pool with formation of a more rapidly turning over smaller pool of VLDL-remnant-TG is the rate-limiting step in overall TG removal from the d<1.006 fraction of rat serum. The data are consistent with our theoretical prediction that under these conditions the kinetics of the VLDL-remnants cannot be resolved from analysis of the total composite “VLDL” (nascent plus remnant) pool.     

Fundamental parameters affecting electrospinning of PAN nanofibers as uniaxially aligned fibers

Electrospinning with a collector consisting of two pieces of electrically conductive substrates separated by a gap has been used to prepare uniaxially aligned PAN nanofibers. Solution of 15 wt % of PAN/DMF was used tentatively for electrospinning. The effects of width of the gap and applied voltage on degree of alignment were investigated using image‐processing technique by Fourier power spectrum method. The electrospinning conditions that gave the best alignment of nanofibers for 10–15 wt % solution concentrations were experimentally obtained. Bundles like multifilament yarns of uniaxially aligned nanofibers were prepared using a new simple method. After‐treatments of these bundles were carried out in boiling water under tension. A comparison was made between the crystallinity and mechanical behavior of posttreated and untreated bundles. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 101: 4350–4357, 2006     

Temporal Hydrologic Alterations Coupled with Climate Variability and Drought for Transboundary River Basins

Climate change (CC) and drought episode impacts linked with anthropogenic pressure have become an increasing concern for policy makers and water resources managers. The current research presents a comprehensive methodology but simple approach for predicting the annual streamflow alteration based on drought indices and hydrological alteration indicators. This has been achieved depending on the evaluation of drought severity and CC impacts during the human intervention periods to separate the influence of climatic abnormality and measure the hydrologic deviations as a result of streamflow regulation configurations. As a representative case study, the Lesser Zab River Basin in northern Iraq has been chosen. In order to analyse the natural flow regime, 34 hydrological years of streamflow (1931–1965) prior to the main dam construction were assessed. The Indicators of Hydrologic Alteration (IHA) method has been applied to quantify the hydrological alterations of various flow characteristics. In addition, an easy approach for hydrological drought prediction in relatively small basins grounded on meteorological parameters during the early months of the hydrological year has been presented. The prediction was accomplished by implementing the one-dimensional drought examination and the reconnaissance drought index (RDI) for evaluating the severity of meteorological drought. The proposed methodology is founded on linear regression relations connecting the RDI of 3, 6, and 12 months and the streamflow drought index (SDI). The results are critical for circumstances where an early exploration of meteorological drought is obtainable. Outcomes assist water resources managers, engineers, policy makers and decision-makers responsible for mitigating the effects of CC.     

Effect of Extraordinary Large Floods on at-site Flood Frequency

The peak flow of extraordinary large floods that occur during a period of systematic record is a controversial problem for flood frequency analysis (FFA) using traditional methods. The present study suggests that such floods be treated as historic flood data even though their historical period is unknown. In this paper, the extraordinary large flood peak was first identified using statistical outlier tests and normal probability plots. FFA was then applied with and without the extraordinary large floods. In this step, two goodness-of-fit tests including mean absolute relative deviation and mean squared relative deviation were used to identify the best-fit probability distributions. Next, the generalized extreme value (GEV), three-parameter lognormal (LN3), log-Pearson type III (LP3), and Wakeby (WAK) probability distributions were used to incorporate and adjust the extraordinary large floods with other systematic data. Finally, procedures with and without historical adjustment were compared for the extraordinary large floods in terms of goodness-of-fit and flood return-period quantiles. The results of this comparison indicate that historical adjustment from an operational perspective was more viable than without adjustment procedure. Furthermore, the results without adjustment were unreasonable (subject to over- and under-estimation) and produced physically unrealistic estimates that were not compatible with the study area. The proposed approach substantially improved the probability estimation of rare floods for efficient design of hydraulic structures, risk analysis, and floodplain management.     

Assessment of Sustainability in Water Supply-Demand Considering Uncertainties

Water is a vital resource for life on earth; hence its maintenance is very important. Different regions especially in arid and semi-arid areas are facing population growth and subsequent increase in the domestic, industrial and agricultural activities. Planning of water systems in order to be ready for future development conditions needs further studies on the estimation of the sustainable levels of demands based on the sustainable levels of supplies. In this study a threefold approach for estimating sustainability level of supply and demand in Ahachay river basin in northwestern part of Iran as a case study is taken. In the first method, the internal flows and the origins and final uses of the total resources for each subsystem are estimated and planning for sustainability use index is determined by calculating the available water. Second method introduced a simulation model which is utilized to estimate reliability, resiliency, vulnerability and maximum deficit for a river basin to determine a group sustainability index. In the third method, for evaluating the movement toward sustainability, an index is developed. This index includes parameters that are the difference between supply and demand, percentage of the satisfied demand, productivity of water resources and an indicator for evaluating the reduction of aquifer storage. Finally these methods are compared and a hybrid index combining the indices is developed. An uncertainty analysis is also performed to investigate the random nature of variables in estimating water balance and quantifying the water sustainability. This hybrid index can be used for evaluating the planning scenarios and for maintaining and improving the sustainable state of supply-demand for the region.     

A polar-based guided multi-objective evolutionary algorithm to search for optimal solutions interested by decision-makers in a logistics network design problem

In practical multi-objective optimization problems, respective decision-makers might be interested in some optimal solutions that have objective values closer to their specified values. Guided multi-objective evolutionary algorithms (guided MOEAs) have been significantly used to guide their evolutionary search direction toward these optimal solutions using by decision makers. However, most guided MOEAs need to be iteratively and interactively evaluated and then guided by decision-makers through re-formulating or re-weighting objectives, and it might negatively affect the algorithms performance. In this paper, a novel guided MOEA that uses a dynamic polar-based region around a particular point in objective space is proposed. Based on the region, new selection operations are designed such that the algorithm can guide the evolutionary search toward optimal solutions that are close to the particular point in objective space without the iterative and interactive efforts. The proposed guided MOEA is tested on the multi-criteria decision-making problem of flexible logistics network design with different desired points. Experimental results show that the proposed guided MOEA outperforms two most effective guided and non-guided MOEAs, R-NSGA-II and NSGA-II.     

Probing the state of absorbed water by diffusion technique

The diffusion coefficient of water, D_wm, across homogeneous cellulose acetate membranes of graded porosity ε (water content) are measured. At high values of porosity, D_wm varies monotonously as ε is varied. At a certain porosity ε_c, however, there is a sudden change in D_wm; and thereafter the change becomes linear again, but with a different slope. Diffusion coefficients are interpreted, through the Stokes-Einstein relation, in terms of the overall microscopic viscosities η_wm of the membrane matrix. The values of η_wm are then correlated with the equivalent pore size r of the membranes. It is discovered that the sudden change in D_wm (or η_wm) at ε_c correlates with similar changes in other properties such as hydraulic permeability and selectivity of the membrane. All these observations are then attributed to the water structure inside the membranes.     

Formal process algebraic modeling,verification, and analysis of an abstract Fuzzy Inference Cloud Service

In cloud computing, services play key roles. Services are well defined and autonomous components. Nowadays, the demand of using Fuzzy inference as a service is increasing in the domain of complex and critical systems. In such systems, along with the development of the software, the cost of detecting and fixing software defects increases. Therefore, using formal methods, which provide clear, concise, and mathematical interpretation of the system, is crucial for the design of these Fuzzy systems. To obtain this goal, we introduce the Fuzzy Inference Cloud Service (FICS) and propose a novel discipline for formal modeling of the FICS. The FICS provides the service of Fuzzy inference to the consumers. We also introduce four novel formal verification tests, which allow strict analysis of certain behavioral disciplines in the FICS as follows: (1) Internal consistency, which analyzes the service in a strict and delicate manner; (2) Deadlock freeness; (3) Divergence freeness; and (4) Goal reach ability. The four tests are discussed and the FICS is verified to ensure that it can pass all these tests.     

PGSW-OS: a novel approach for resource management in a semantic web operating system based on a P2P grid architecture

A web operating system is an operating system that users can access from any hardware at any location. A peer-to-peer (P2P) grid uses P2P communication for resource management and communication between nodes in a grid and manages resources locally in each cluster, and this provides a proper architecture for a web operating system. Use of semantic technology in web operating systems is an emerging field that improves the management and discovery of resources and services. In this paper, we propose PGSW-OS (P2P grid semantic Web OS), a model based on a P2P grid architecture and semantic technology to improve resource management in a web operating system through resource discovery with the aid of semantic features. Our approach integrates distributed hash tables (DHTs) and semantic overlay networks to enable semantic-based resource management by advertising resources in the DHT based upon their annotations to enable semantic-based resource matchmaking. Our model includes ontologies and virtual organizations. Our technique decreases the computational complexity of searching in a web operating system environment. We perform a simulation study using the Gridsim simulator, and our experiments show that our model provides enhanced utilization of resources, better search expressiveness, scalability, and precision.     

Admittance—Frequency Response in Zinc Oxide Varistor Ceramics

The lumped parameter/complex plane analysis technique revealed several contributions to the terminal admittance of the ZnO—Bi₂O₃ based varistor grain-boundary ac response. The terminal capacitance has been elucidated via the multiple trapping phenomena, a barrier layer polarization, and a resonance effect in the frequency range 10⁻²≤ f ≤ 10⁹ Hz. The characterization of the trapping relaxation behavior near ∼ 10⁵ Hz (∼ 10⁻⁶ s) provided a better understanding of a previously reported loss-peak. The possible nonuniformity in this trapping activity associated with its conductance term observed via the depression angle of a semicircular relaxation in the complex capacitance ( C *) plane has been postulated.