Estimation of froth flotation recovery and collision probability based on operational parameters using an artificial neural network

An artificial neural network and regression procedures were used to predict the recovery and collision probability of quartz flotation concentrate in different operational conditions. Flotation parameters, such as dimensionless numbers (Froude, Reynolds, and Weber), particle size, air flow rate, bubble diameter, and bubble rise velocity, were used as inputs to both methods. The linear regression method shows that the relationships between flotation parameters and the recovery and collision probability of fl...     

Improving adaptive receivers performance in molecular communication via diffusion

Forthcoming applications for molecular communications (MC) such as drug‐delivery and health monitoring will require robust receiver capabilities to mitigate channel memory and inter symbol interference caused by previous transmitted symbols. Here, the authors introduce an adaptive weighted algorithm to reduce the influence of these factors. This novel signal detection is deployed on to a concentration‐based MC system with absorbing receiver which is based on the so‐called first passage time concept. The proposed detector has low complexity and does not require explicit channel knowledge. To evaluate authors’ proposed algorithm, a theoretical approach is developed to derive the bit error rate (BER). Numerical results also carried out to verify the accuracy of these formulations and establish that the new detector will achieve better performance in comparison with other common low‐complex detectors under certain scenarios. Additionally, the authors propose a simple pre‐coding technique to combat the sequence of consecutive ones in low ISI scenarios. Also a comparison between detectors is given, which is based on the variation of distance, symbol period, signal‐to‐noise ratio (SNR), and number of molecules.Inspec keywords: radio receivers, error statistics, signal detection, intersymbol interferenceOther keywords: low‐complex detectors, low ISI scenarios, symbol period, signal‐to‐noise ratio, adaptive receivers performance, molecular communication, drug‐delivery, health monitoring, robust receiver capabilities, channel memory, inter symbol interference, previous transmitted symbols, adaptive weighted algorithm, novel signal detection, concentration‐based MC system, absorbing receiver, passage time concept, low complexity, explicit channel knowledge, authors, theoretical approach, bit error rate, numerical results     

Exergetic sustainability evaluation and optimization of an irreversible Brayton cycle performance

Owing to the energy demands and global warming issue, employing more effective power cycles has become a responsibility. This paper presents a thermodynamical study of an irreversible Brayton cycle with the aim of optimizing the performance of the Brayton cycle. Moreover, four different schemes in the process of multi-objective optimization were suggested, and the outcomes of each scheme are assessed separately. The power output, the concepts of entropy generation, the energy, the exergy output, and the exergy efficiencies for the irreversible Brayton cycle are considered in the analysis. In the first scheme, in order to maximize the exergy output, the ecological function and the ecological coefficient of performance, a multi-objective optimization algorithm (MOEA) is used. In the second scheme, three objective functions including the exergetic performance criteria, the ecological coefficient of performance, and the ecological function are maximized at the same time by employing MOEA. In the third scenario, in order to maximize the exergy output, the exergetic performance criteria and the ecological coefficient of performance, a MOEA is performed. In the last scheme, three objective functions containing the exergetic performance criteria, the ecological coefficient of performance, and the exergy-based ecological function are maximized at the same time by employing multi-objective optimization algorithms. All the strategies are implemented via multi-objective evolutionary algorithms based on the NSGAII method. Finally, to govern the final outcome in each scheme, three well-known decision makers were employed.     

POLYNUCLEAR AROMATIC COMPOUNDS IN COAL AND OIL SHALE WASTEWATER: AN ENVIRONMENTAL CONCERN

ABSTRACT

A solvent refining coal liquefaction process recycle water (No. 3) from Du Pont, Washington, a true in-situ oil shale retort water (Omega-9) from Rock Springs, Wyoming, and a ten-ton unit simulated in-situ oil shale retort water (No, 16) from Laramie, Wyoming, were subjected to solvent extraction procedure and subsequent instrumental analysis including: (a) high performance liquid chromatography (HPLC) of polynuclear aromatics (PNA's) having more than four rings; (b) capillary gas chromatography (GC) of low molecular weight volatile PNA's; and (c) gas chromatography-mass spectrometry (GC-MS) for complementary identification of PNA's having functional and heterocyclic modifications.

A total of 41 PNA's were identified. Identification of 28 PNA's in the coal derived water (No. 3) was attained, whereas that of the true in-situ retort water (Omega-9) and the simulated retort water (No. 16) were 24 and 18, respectively. Thirteen PNA's were found to be common to all three wastewater samples. Thirteen PNA's were exclusively found in sample No. 3 whereas that of samples Omega-9 and No. 16 were 8 and 4, respectively. It was estimated that the concentration of PNA's in all samples ranged from traces to 30.0 ppb.     

X-Ray Measurement and Enhancement of SBUPF1 Plasma Focus Device in Different Ar Pressures and Operating Voltages

In this paper, best condition of filling gas pressure and operating voltage for SBUPF1 plasma focus device to have maximum intensity of hard and soft X-ray emission has been reported. For time resolved X-ray detection, PIN detector and fast plastic Scintillator detector with appropriate filters have been used and for time integrated X-ray emission measurement, radiography films with appropriate filter masks have been used. Rogowski coil has been used for pinch detection. The highest hard X-ray emission has been observed at the pressure of 0.45 mbar of Argon and discharge voltage about 23.5 kV. The highest Soft X-ray emission has been observed at the pressure of 0.35 mbar of Argon and discharge voltage about 23.5 kV. For enhancement of hard X-ray emission intensity, lead disk was placed in copper anode tip and measurements were repeated. Results have shown that hard X-ray emission has been enhanced about 23% and soft X-ray emission has been enhanced about 33% with inserting a high atomic number metal disk like lead. Results from integral X-ray measurement have shown presence of dominant peaks in ranges 13.2–15, 21–21.9 and 23.4–24.3 keV with significant spectral components in the range of 0–50 keV. Pinch size has measured with pin hole camera and it is about 0.6 mm × 2.12 mm. Captured images with SBUPF1 have confirmed that it is a suitable source for introspective imaging with capability of showing very fine details.     

Cannabinoids and Chronic Liver Diseases

Nonalcoholic fatty liver disease (NAFLD), alcohol-induced liver disease (ALD), and viral hepatitis are the main causes of morbidity and mortality related to chronic liver diseases (CLDs) worldwide. New therapeutic approaches to prevent or reverse these liver disorders are thus emerging. Although their etiologies differ, these CLDs all have in common a significant dysregulation of liver metabolism that is closely linked to the perturbation of the hepatic endocannabinoid system (eCBS) and inflammatory pathways. Therefore, targeting the hepatic eCBS might have promising therapeutic potential to overcome CLDs. Experimental models of CLDs and observational studies in humans suggest that cannabis and its derivatives may exert hepatoprotective effects against CLDs through diverse pathways. However, these promising therapeutic benefits are not yet fully validated, as the few completed clinical trials on phytocannabinoids, which are thought to hold the most promising therapeutic potential (cannabidiol or tetrahydrocannabivarin), remained inconclusive. Therefore, expanding research on less studied phytocannabinoids and their derivatives, with a focus on their mode of action on liver metabolism, might provide promising advances in the development of new and original therapeutics for the management of CLDs, such as NAFLD, ALD, or even hepatitis C-induced liver disorders.     

Surface Decoration of Peptide Nanoparticles Enables Efficient Therapy toward Osteoporosis and Diabetes

A versatile surface decoration strategy to efficiently encapsulate water-soluble peptides is developed. By assembling peptide molecules into nanoparticles, diverse physiochemical properties of these compacted molecules are equalized to the surface properties of nanoparticles. Primarily driven by the generic electrostatic attractions, the surface of as-prepared peptide nanoparticles is decorated with charged amino acids-grafted poly(lactic-co-glycolic acid). This adsorbed polymer layer versatilely blocks the phase transfer of peptide nanoparticles by increasing their affinity to the dispersed phase solvent molecules. Attributed to the ultrahigh encapsulation efficiencies (> 96%), the peptide mass fraction inside the obtained microcomposites is higher than 48%. The plasma calcium level has been efficiently reduced for ≈3 weeks with only one single injection of salmon calcitonin-encapsulated microcomposite in osteoporotic rats. Similarly, one single injection of exenatide-encapsulated microcomposites efficiently controls the glycemic level in type 2 diabetic rats for up to 3 weeks. Overall, the developed versatile surface decoration strategy efficiently encapsulates peptides and improves their pharmacokinetic features, regardless of the molecular structure of peptide cargos.     

Enhancing Apoptosome Assembly via Mito-Biomimetic Lipid Nanocarrier for Cancer Therapy

Apoptosis is the natural programmed cell death process, which is responsible for abnormal cell clearance. However, many cancer cells develop various mechanisms to escape apoptosis through interrupting apoptosome assembly, which is a key step to initiate apoptosis. This promotes tumorigenesis and drug resistance, and thus, poses a great challenge in cancer treatment. Herein, a biomimetic lipid nanocarrier mimicking mitochondrial Cytochrome C (Cyt C) binding is developed. Cardiolipin, the major phospholipid of mitochondrial inner membrane, is introduced as the main component in biomimetic liposomal formulation. With the help of cardiolipin, Cyt C is sufficiently loaded in liposome based on electrostatic and hydrophobic interaction with cardiolipin. Lonidamine (LND) is added in hydrophobic phase of liposome to modulate the metabolic activity within cancer cells and sensitize the cells to Cyt C-induced apoptosis. The results suggest that LND reduces ATP level and creates favorable environment for Cyt C induced apoptosome assembly, exhibiting higher apoptosis level and anti-tumor efficacy in vitro and in vivo. The conjugation of a tumor-homing peptide, LinTT1, on the nanovesicle, increases the efficacy due to enhanced tumor accumulation. Overall, this biomimetic lipid nanocarrier proves to be an efficient delivery system with great potential of pro-apoptosis cancer therapy.     

Immunomodulatory Hydrogels: Advanced Regenerative Tools for Diabetic Foot Ulcer

Diabetic foot ulcer (DFU) is one of the most common complications of diabetes, bringing physical and mental challenges for patients due to the lack of efficient curative therapy. Despite considerable advances in pharmacological and surgical approaches, clinical trials for DFU patients remain disappointing due to the local overactive and excessive inflammation. Immunomodulatory hydrogels has significant advantages to overcome the clinical challenge of DFUs therapy. Here, recent fabrication and regenerative advances in the utilization of functional hydrogels for altering the immune microenvironment of DFUs are comprehensively reviewed. The pathological features and the healing processes of DFUs, followed by summarizing the physicochemical properties essential for the design of regenerative hydrogels for immunomodulation in DFUs, are briefly introduced. Then, the potential immuno-therapeutic modalities of hydrogels and emerging trends used to treat DFUs via multitherapeutic approaches and enhanced efficacy and safety are discussed. Taken together, by linking the structural properties of hydrogels to their functions in DFU therapy with a particular focus on immunomodulatory stimuli, this review can promote further advances in designing advanced hydrogels for DFUs, resulting in improved diabetic wound repair through translation into clinical setting in the near future.