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991.
Drill-pipe corrosion is a critical issue for any drilling operation, particularly under high-pressure, high-temperature downhole conditions. However, most laboratory studies have been conducted under ambient and static conditions, with only a few downhole studies based on flow loop showing inconsistent results. In this study, we proposed a novel simple method to simulate pipe corrosion/erosion in a reservoir-like environment under both the static and dynamic conditions and investigated the influences of wellbore conditions, including temperature, pressure and salinity of water-based drilling fluids, on the corrosion behaviour of the drill pipe. The results showed that the erosion effect of the drilling fluid (without drilled cuttings) was negligible. Furthermore, we found that the corrosion rate increased with an increase in the temperature, pressure and rotational speed; however, it decreased with an increase in the salinity. In addition, the proposed method can be used to simulate other complicated conditions. 相似文献
992.
Asita Elengoe Mohammed Abu Naser Salehhuddin Hamdan 《International journal of molecular sciences》2014,15(4):6797-6814
The purpose of exploring protein interactions between human adenovirus and heat shock protein 70 is to exploit a potentially synergistic interaction to enhance anti-tumoral efficacy and decrease toxicity in cancer treatment. However, the protein interaction of Hsp70 with E1A32 kDa of human adenovirus serotype 5 remains to be elucidated. In this study, two residues of ATPase domain of human heat shock 70 kDa protein 1 (PDB: 1 HJO) were mutated. 3D mutant models (K71L and T204V) using PyMol software were then constructed. The structures were evaluated by PROCHECK, ProQ, ERRAT, Verify 3D and ProSA modules. All evidence suggests that all protein models are acceptable and of good quality. The E1A32 kDa motif was retrieved from UniProt (), as well as subjected to docking interaction with NBD, K71L and T204V, using the Autodock 4.2 program. The best lowest binding energy value of −9.09 kcal/mol was selected for novel T204V. Moreover, the protein-ligand complex structures were validated by RMSD, RMSF, hydrogen bonds and salt bridge analysis. This revealed that the T204V-E1A32 kDa motif complex was the most stable among all three complex structures. This study provides information about the interaction between Hsp70 and the E1A32 kDa motif, which emphasizes future perspectives to design rational drugs and vaccines in cancer therapy. P03255相似文献
993.
Mohammed Halayqa Urszula Domańska 《International journal of molecular sciences》2014,15(12):23909-23923
In our study, poly(dl-lactide-co-glycolide) (PLGA) nanoparticles loaded with perphenazine (PPH) and chlorpromazine hydrochloride (CPZ-HCl) were formulated by emulsion solvent evaporation technique. The effect of various processing variables, including PLGA concentration, theoretical drug loading, poly(vinyl alcohol) (PVA) concentration and the power of sonication were assessed systematically to obtain higher encapsulation efficiency and to minimize the nanoparticles size. By the optimization formulation process, the nanoparticles were obtained in submicron size from 325.5 ± 32.4 to 374.3 ± 10.1 nm for nanoparticles loaded with PPH and CPZ-HCl, respectively. Nanoparticles observed by scanning electron microscopy (SEM) presented smooth surface and spherical shape. The encapsulation efficiency of nanoparticles loaded with PPH and CPZ-HCl were 83.9% and 71.0%, respectively. The drug loading were 51.1% and 39.4% for PPH and CPZ-HCl, respectively. Lyophilized nanoparticles with different PLGA concentration 0.8%, 1.3% and 1.6% (w/v) in formulation process were evaluated for in vitro release in phosphate buffered saline (pH = 7.4) by using dialysis bags. The release profile for both drugs have shown that the rate of PPH and CPZ-HCl release were dependent on a size and amount of drugs in the nanoparticles. 相似文献
994.
Effects of epoxidized natural rubber (ENR‐50) and processing parameters on the properties of NR/EPDM blends using response surface methodology
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Noraiham Mohamad Juliana Yaakub Jeefferie Abd Razak Mohd Yuhazri Yaakob Mohammed Iqbal Shueb Andanastuti Muchtar 《应用聚合物科学杂志》2014,131(17)
The effects of epoxidized natural rubber (ENR‐50) and processing parameters on the properties of natural rubber/ethylene–propylene–diene rubber (NR/EPDM; 70 : 30 phr) blends were studied. The compounds were prepared by melt compounding method. Using response surface methodology of two‐level full factorial, the effects of ENR‐50 contents (?1 : 5 phr; +1 : 10 phr), mixing temperature (?1 : 50°C; +1 : 110°C), rotor speed (?1 : 40 rpm; +1 : 80 rpm), and mixing time (?1 : 5 min; +1 : 9 min) in NR/EPDM blends were evaluated. Cure characteristics and tensile properties were selected as the responses. The significance of factors and its interaction was analyzed using ANOVA and the model's ability to represent the system was confirmed using the constant of determination, R2 with values above 0.90. It was found that the presence of ENR‐50 has the predominant role on the properties of NR/EPDM blends. The addition of ENR‐50 significantly improved cure characteristics and tensile strength up to 5.12% and 6.48% compared to neat NR/EPDM blends, respectively. These findings were further supported by swell measurement, differential scanning calorimetry, and scanning electron microscopy. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 40713. 相似文献
995.
Nida Iqbal Mohammed Rafiq Abdul Kadir Nasrul Humaimi Mahmood Norita Salim Gabriele R.A. Froemming H.R. Balaji Tunku Kamarul 《Ceramics International》2014
We investigated the possibility of enhancing hydroxyapatite (HA) bioactivity by co-substituting it with zinc and silver. Zn–Ag–HA nanoparticles were synthesized by using the microwave-assisted wet precipitation process, and their phase purity, elemental composition, morphology, and particle size were analyzed by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDX). FTIR, XRD, and EDX results showed the characteristic peaks of the Zn–Ag–HA structure, while SEM results demonstrated that the nanoparticles were of spherical shape with a particle size of 70–102 nm. Antibacterial tests of the nanoparticles revealed their antibacterial activity against Staphylococcus aureus and Escherichia coli. By using simulated body fluid (SBF), an apatite layer formation was observed at 28 days. In vitro cell adhesion assay confirmed the cell attachment of normal human osteoblast (NHOst) cells to the disc surface. MTT [(3(4, 5-dimethylthiazol-2-yl)-2, 5 diphenyltetrazolium bromide] assay indicated that the cells were viable, and the cells proliferated faster on the disks than on the control surface due to the presence of metal ions. In conclusion, the novel Zn–Ag–HA nanoparticles were found to be compatible with in vitro experiments and having potential antibacterial properties. Therefore these nanoparticles could be a promising candidate for future biomedical applications. 相似文献
996.
Mohammed Noushad Ismail Ab Rahman Noor Sheeraz Che Zulkifli Adam Husein Dasmawati Mohamad 《Ceramics International》2014
This study aimed to obtain nanosilica with desirable characteristics from an agricultural biomass waste using an organic acid. The effect of the feed rate of the precipitant and the mixing speed on the morphology and characteristics of nanosilica from rice husk for use as fillers in dental nanocomposites has been explored. The feed rate showed considerable effects on the agglomeration and the size of the silica nanoparticles. At a feed rate of 0.2 ml/min, the particles were bigger and highly agglomerated with a mean particle size of 261 nm. The mean particle sizes for the feed rates of 1 ml/min and 5 ml/min were 213 nm and 174 nm, respectively, exhibiting a decrease in the mean particle size with increasing feed rate. The shape of the silica nanoparticles depended on the mixing speed and it was possible to obtain spherical, dense, low surface area silica particles suitable for use in the fabrication of dental nanocomposites using this simple technique. 相似文献
997.
998.
Malik Abdul Rub Abdullah M. Asiri Mohmad Shafi Sheikh Naved Azum Anish Khan Aftab Aslam Parwaz Khan Mohammed M. Rahman Kabir-ud-Din 《Journal of surfactants and detergents》2014,17(1):37-48
The interaction between the amphiphilic drug amitriptyline hydrochloride (AMT) and the nonionic surfactants used in drug delivery has been investigated. Herein, we report the micellization behavior of AMT in presence of ethoxylated alkyl phenols in aqueous medium and the clouding phenomenon in the absence and presence of different nonionic surfactants in buffer solution. The values of critical micelle concentration (CMC) of AMT obtained using the conductivity method, decrease as nonionic surfactant concentration increases. With an increase in temperature, the CMC first increases and then decreases. At 303.15 K, the maximum CMC values were obtained with or without nonionic surfactant. The results obtained indicate attractive interactions (synergism) between the two mixing amphiphiles in solution. The experimentally obtained critical micelle concentration (CMC) values are always lower than ideal CMC values. Micellar mole fraction (X1) values, calculated by different proposed models, show the contribution of nonionic surfactant concentration. At a fixed drug concentration (50 mmol kg?1) and pH (=6.7) nonionic surfactants show continuous increase in cloud point (CP). Increase in drug concentration and pH, in the presence of fixed amounts of nonionic surfactant, increases and decreases the CP, respectively. 相似文献
999.
Mohammed I. Zougari 《Journal of Petroleum Science and Engineering》2010,70(1-2):28-34
Comprehensive testing of waxy crude oil solid deposition using a recently developed device based on Taylor–Couette flow under both live (single-phase) and stock tank conditions was performed. The analysis included wax solid deposition as a function of time (kinetics), shear (dynamics), temperature (heat transfer) and pressure. The study revealed good deposit reproducibility under consistent test conditions. Moreover, collected experimental deposition results from the Taylor–Couette flow device demonstrated proper deposition trends and profiles as a function of the selected variables. In particular, the results confirmed that the deposition increases with the increase of heat transfer and kinetics, and deceases with an increase of shear at the wall. 相似文献
1000.
The pitting corrosion of Al, and two Al-Cu alloys, namely (Al-2.5% Cu) and (Al-7.0% Cu) was investigated in gluconic acid (HG) solution through linear polarization and cyclic voltammetry techniques complemented with ex situ EDX and SEM examinations of the electrode surface. Inductively coupled plasma-atomic emission spectroscopy (ICP-AES) method of chemical analysis was used to study the effect of alloyed Cu on the rate of the uniform corrosion of Al in these solutions. Results obtained from ICP were compared with those obtained from polarization measurements. For the three Al samples, the anodic responses did not involve active/passive transition due to spontaneous passivation. Addition of HG induced pitting (confirmed from SEM) within the passive oxide film due to the aggressive attack of gluconate (G−) anions. Relationships between pitting potential (Epit), HG concentration, temperature, pH and potential scan rate were established. Alloyed Cu was found to enhance uniform corrosion, while it suppressed pitting attack. Local acidification model is employed to explain passivity breakdown induced by pitting corrosion as a result of the aggressive attack of G− anions. 相似文献