Analysis of regenerative chatter suppression with adding the ultrasonic elliptical vibration on the cutting tool

A method is proposed to suppress regenerative chatter in turning operation, in which the ultrasonic elliptical vibration is added on the cutting tool. It results in the fact that the cutting tool is separated periodically from the chip and the workpiece, and the direction of the frictional force between the rake face of the cutting tool and the chip is reversed in each cycle of the ultrasonic elliptical vibration. The experimental investigations show that the regenerative chatter occurring in ordinary turning operation can be suppressed effectively by applying the ultrasonic elliptical vibration on the cutting tool. In order to clearify the reason of the regenerative chatter suppression, theoretical analysis and computer simulation are performed on turning with ultrasonic vibration. There is a good agreement among the experimental investigations, theoretical analysis and the computer simulation.     

Comparison of age-related changes in wrinkling and sagging of the skin in Caucasian females and in Japanese females

Although adhesion failure in hair fibers can occur inside cells, it occurs more frequently in the cell membrane complex (CMC), often involving the rupture of interlayer bonds. Therefore, a model of the CMC presented, based on prior research, in which we propose interconnecting bonds between the layers to assist interpretation of hair-fracturing mechanisms for cuticle chipping, deep transverse cuticle cracks, during heat drying, scale lifting by surfactants, and catastrophic failure. Failure in the wet state involves hydrophilic layers, e.g. the contact zone of the CMC or the endocuticle or bonding to hydrophilic layers, whereas failure in the dry state generally involves bonding between hydrophobic, e.g. beta-delta failure. Chemical damage by perms, bleaches, and sunlight, by breaking specific bonds, influences the sites of initial failure and increases the number of routes for crack propagation, leading to more complex fracture patterns.     

Nucleotide sequence of the cDNA encoding nucleoside diphosphate kinase II from spinach leaves

The primary structure of nucleoside diphosphate (NDP) kinase II, one of the two isozymes found in spinach leaves, has been deduced from its cDNA sequence. NDP kinase II comprises 233 amino acid residues and has a molecular mass of 26,107 Da, which is larger than that of the purified NDP kinase II subunits (18 kDa) by about 8 kDa, suggesting that NDP kinase II might be post-translationally processed. Homology was found between the sequence of spinach NDP kinase II, and the sequences of spinach NDP kinase I, rat NDP kinases alpha and beta, Dictyostelium discoideum NDP kinase, the human Nm23-H1 and Nm23-H2 proteins and the awd protein of Drosophila melanogaster.     

9,13-di-cis-Retinoic acid induces the production of tPA and activation of latent TGF-beta via RAR alpha in a human liver stellate cell line, LI90

Fas(Apo-1/CD95), a receptor belonging to the tumor necrosis factor receptor family, induces apoptosis when triggered by Fas ligand. Upon its activation, the cytoplasmic domain of Fas binds several proteins which transmit the death signal. We used the yeast two-hybrid screen to isolate Fas-associated proteins. Here we report that the ubiquitin-conjugating enzyme UBC9 binds to Fas at the interface between the death domain and the membrane-proximal region of Fas. This interaction is also seen in vivo. UBC9 transiently expressed in HeLa cells bound to the co-expressed cytoplasmic segment of Fas. FAF1, a Fas-associated protein that potentiates apoptosis (Chu et al. (1996) Proc. Natl. Acad. Sci. USA 92, 11894-11898), was found to contain sequences similar to ubiquitin. These results suggest that proteins related to the ubiquitination pathway may modulate the Fas signaling pathway.     

Polarization-Insensitive Operation of Lithium Niobate Mach–Zehnder Interferometer With Silica PLC-Based Polarization Diversity Circuit

We demonstrate the polarization-insensitive operation of a Mach-Zehnder interferometer (MZI)-based lithium niobate switch with a silica waveguide polarization beam splitter. The splitter is composed of an MZI with a half wave plate installed in one arm, and exhibits a polarization extinction ratio of more than 15 dB. The switch functions for both polarizations with an extinction ratio of more than 20 dB, a polarization-dependent loss of 0.1 dB and a switching speed of 40 ps.     

Hepatocyte nuclear factor-4 alpha gene mutations in Japanese non-insulin dependent diabetes mellitus (NIDDM) patients

OBJECTIVE: To assess the effect of pregnancy, maternal position, and cardiac output on intrapulmonary shunting (Qs/Qt) in normotensive nulliparous women near term. METHODS: Ten normotensive nulliparas between 36 and 38 weeks' gestation underwent pulmonary artery catheterization (via the subclavian route) and radial artery canalization. Baseline assessments were made with subjects in the left lateral recumbent position after a 30-minute stabilization period. Measurements were obtained sequentially in the left lateral, right lateral, supine, knee-chest, sitting, and standing positions. Each position change was followed by a 10-minute pre-measurement stabilization period. Cardiac output was measured via the thermodilution technique. Blood samples were obtained simultaneously from the pulmonary and radial arteries and analyzed in duplicate for oxygen content with a blood gas analyzer. Qs/Qt was calculated using the classic shunt equation. Statistical analysis was performed by analysis of variance of repeated measures of Qs/Qt and maternal position. The relationship of Qs/Qt to maternal cardiac output was evaluated by the correlation coefficient. Significance was defined as P < .05. RESULTS: Directly measured Qs/Qt averaged 15.3% in left lateral, 15.2% in right lateral, 13.9% in supine, 12.8% in knee-chest, 13.8% in sitting, and 13.0% in standing positions. There was no statistically significant correlation between Qs/Qt and cardiac output (R2 = 0.11, not significant). CONCLUSION: This is the first report of directly measured Qs/Qt in normal pregnant women in the third trimester. Qs/Qt values reported in pregnancy are higher than those reported in nonpregnant individuals.     

A horse chestnut extract, which induces contraction forces in fibroblasts, is a potent anti-aging ingredient

Contraction forces generated by non-muscle cells, such as fibroblasts, play important roles in determining cell morphology, vasoconstriction, and/or wound healing. We have searched among various plant extracts for ingredients that generate cell contraction forces using fibroblast-populated collagen gels. Using that model, we found that an extract of horse chestnuts ( Aesculus hippocastanum ) is able to generate such contraction forces in fibroblasts. The involvement of stress fiber formation in that response is suggested by the inhibition of such force generation by cytochalasin D and rhodamine phalloidin stain. Clinical testing of the extract was carried out using 40 healthy female volunteers. A gel formulation that included 3% of the extract was applied topically to the skin around the eye three times daily for 9 weeks. The efficacy of the extract to diminish wrinkles was evaluated by visual scoring based on photo scales. After 6 weeks, significant decreases in the wrinkle scores at the corners of the eye or in the lower eyelid skin were observed compared with controls. After 9 weeks, similar results were obtained. Taken together, our results suggest that an extract of horse chestnuts can generate contraction forces in fibroblasts and is a potent anti-aging ingredient.     

Quantitative two-dimensional analysis of facial wrinkles of Japanese women at various ages

To evaluate individual differences in the recognition of facial wrinkles, we asked 40 Japanese female observers to identify wrinkles using transparent sheets over frontal facial photos of four females aged 20, 39, 55 or 75 years. We then measured the number and length of those wrinkles by image analysis. Wrinkles identified by those 40 observers showed aged-related increases in the standard deviation (SD) values for number and length but age-related decreases in the coefficient of variation (CV)%. Therefore, to clarify factors affecting the degree of wrinkle detection, wrinkles were identified by two groups of age-matched male and female observers, by two groups that differed by age, and by two other groups, one of which who felt that there was an improvement in their wrinkles after application of an antiwrinkle agent and another group who did not feel that there was any improvement after the same treatment. Improvement was observed by replica image analysis in all groups. The degree of wrinkles identified was not affected by the age or by the sex of the observer group. However, the group who felt that there was an improvement in their wrinkles after treatment with the antiwrinkle agent identified a significantly higher number of wrinkles than did the group who did not feel that there was an improvement. These results suggest marked individual differences in the recognition of wrinkles. Fine wrinkles in relatively young subjects are difficult to detect, but moderate to marked wrinkles in middle-aged and in aged subjects can easily be detected. Concerning the cause of individual differences in the extent of wrinkle detection, observers who identified a large number of wrinkles tended to recognize not only pronounced wrinkles but also recognized fine wrinkles as 'wrinkles'. This seems to have also affected their feelings about the success of treatment with the antiwrinkle agent.