Effect of phenylhydrazine on delta-aminolevulinic acid dehydratase in red blood cells

Delta-aminolevulinic acid dehydratase activity was measured in the blood of rats poisoned by successive injections of phenylhydrazine (1 ml, 35 mmol). After 5 days of successive injections, more than 90% of the circulating blood cells consisted of reticulocytes and the enzyme activity also increased successively and reached a maximum corresponding to the number of reticulocytes. Thus delta-aminolevulinic acid dehydratase activity measured in the peripheral blood is mainly due to the percentage of circulating reticulocytes.     

Progressive Compression of 3D Mesh Geometry Using Sparse Approximations from Redundant Frame Dictionaries

In this paper, we present a new approach for the progressive compression of three‐dimensional (3D) mesh geometry using redundant frame dictionaries and sparse approximation techniques. We construct the proposed frames from redundant linear combinations of the eigenvectors of a combinatorial mesh Laplacian matrix. We achieve a sparse synthesis of the mesh geometry by selecting atoms from a frame using matching pursuit. Experimental results show that the resulting rate‐distortion performance compares favorably with other progressive mesh compression algorithms in the same category, even when a very simple, sub‐optimal encoding strategy is used for the transmitted data. The proposed frames also have the desirable property of being able to be applied directly to a manifold mesh having arbitrary topology and connectivity types; thus, no initial remeshing is required and the original mesh connectivity is preserved.     

Plasma myeloperoxidase,NT‐proBNP,and troponin‐I in patients on CAPD compared with those on regular hemodialysis

Myeloperoxidase (MPO) is a hemoprotein that is released during inflammation and may lead to irreversible protein and lipid modification, increasing levels of oxidized low density lipoprotein, and promoting athrogenesis. Recently, it has been considered as a risk factor for cardiovascular diseases. Similarly, the measurement of carotid intima‐media thickness gives an indication about the degree of atherosclerosis and prediction of clinical cardiovascular events. Elevated white blood cells counts may indicate a state of acute inflammation and follow its progression. Dialysis patients are at a high risk of developing cardiovascular disease compared with healthy subjects. The role of N‐terminal pro‐brain natriuretic peptide and increased cardiac troponin in identification and prognostication of cardiovascular diseases in end‐stage renal disease patients has been investigated. The current study aimed to evaluate plasma MPO and its possible relationship with carotid intima‐media thickness, troponin I, N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), and insulin resistance as measured by homeostatic model assessment (HOMA index) in a cohort of Saudi patients who are undergoing hemodialysis (HD) vs. continuous ambulatory peritoneal dialysis for end‐stage renal disease. Plasma MPO was significantly higher in patients on continuous ambulatory peritoneal dialysis (CAPD) than in those on HD and in normal subjects (P<0.001). Conversely, NT‐proBNP plasma levels were significantly higher in patients on HD (both predialysis and postdialysis) than in those on CAPD (P<0.01) and than normal subjects. Similarly, plasma troponin‐I levels were significantly higher in patients on HD compared with those of CAPD and than normal subjects (P<0.001). Plasma troponin‐I and NT‐proBNP levels were positively correlated in the 3 groups namely those on CAPD, Pre‐HD, and post‐HD (r: 0.464 and P=0.047; r: 0.330 and P=0.013; and r: 0.452 and P=0.024), respectively. There was no correlation between the MPO level and carotid intima‐media thickness (P>0.05). However, plasma MPO level correlated positively with the white blood cell count in patients on CAPD and in those on HD (P<0.05). Our findings suggest an increased oxidative stress in CAPD patients compared with HD patients, while the reported difference in plasma NT‐proBNP and troponin‐I may be related to the rapid decline of residual renal function in HD and type of membrane used in the HD dialysis procedure itself.     

Acute Oral Toxicity Evaluations of Some Zinc(II) Complexes Derived from 1-(2-Salicylaldiminoethyl)piperazine Schiff Bases in Rats

The current study described the synthesis and the in vivo acute oral toxicity evaluations in Sprague Dawley rats. The compounds were characterized by elemental analyses, LC-MS, FTIR, (1)H NMR, (13)C NMR and UV-visible spectroscopy. In the acute toxicity study, a single administration of the compounds was performed orally to the rats at the single doses of 2000 mg/kg and they were then monitored for possible side effects, mortality or behavioral changes up to 14 days. The serum level of aspartate (AST), alanine aminotransferases (ALT), alkaline phosphate (ALP), triglyceride, high density lipoprotein (HDL), immunoglobulins (GAM) and the C-reactive proteins did not significantly change. The hematological indices white blood cells (WBC), haematocrit (HCT), red blood cells (RBC), mean corpuscular volume (MCV), mean corpuscular haemoglobin concentration (MCHC), and mean corpuscular hemoglobin (MCH) were within the normal range. The renal function indices examined were also within the reference range. Generally, the compounds exhibited low toxic effects as required for further in vivo therapeutic studies.     

Partial differential equation-based approach for empirical mode decomposition: application on image analysis

The major problem with the empirical mode decomposition (EMD) algorithm is its lack of a theoretical framework. So, it is difficult to characterize and evaluate this approach. In this paper, we propose, in the 2-D case, the use of an alternative implementation to the algorithmic definition of the so-called "sifting process" used in the original Huang's EMD method. This approach, especially based on partial differential equations (PDEs), was presented by Niang in previous works, in 2005 and 2007, and relies on a nonlinear diffusion-based filtering process to solve the mean envelope estimation problem. In the 1-D case, the efficiency of the PDE-based method, compared to the original EMD algorithmic version, was also illustrated in a recent paper. Recently, several 2-D extensions of the EMD method have been proposed. Despite some effort, 2-D versions for EMD appear poorly performing and are very time consuming. So in this paper, an extension to the 2-D space of the PDE-based approach is extensively described. This approach has been applied in cases of both signal and image decomposition. The obtained results confirm the usefulness of the new PDE-based sifting process for the decomposition of various kinds of data. Some results have been provided in the case of image decomposition. The effectiveness of the approach encourages its use in a number of signal and image applications such as denoising, detrending, or texture analysis.     

Reducing cell loss in banyan based ATM switching fabrics

In this paper, we propose a new technique for reducing cell loss in multi‐banyan‐based ATM switching fabrics. We propose a switch architecture that uses incremental path reservation based on previously established connections. Path reservation is carried out sequentially within each banyan but multiple banyan planes can be concurrently reserved. We use a conflict resolution approach according to which banyans make concurrent reservation offers of conflict‐free paths to head of the line cells waiting in input buffers. A reservation offer from a given banyan is allocated to the cell whose source‐to‐destination path uses the largest number of partially allocated switching elements which are shared with previously reserved paths. Paths are incrementally clustered within each banyan. This approach leaves the largest number of free switching elements for subsequent reservations which has the effect of reducing the potential of future conflicts and improves throughput. We present a pipelined switch architecture based on the above concept of path‐clustering which we call path‐clustering banyan switching fabric (PCBSF). An efficient hardware that implements PCBSF is presented together with its theoretical basis. The performance and robustness of PCBSF are evaluated under simulated uniform traffic and ATM traffic. We also compare the cell loss rate of PCBSF to that of other pipelined banyan switches by varying the switch size, input buffer size, and traffic pattern. Copyright © 2001 John Wiley & Sons, Ltd.     

Efficient orientation impacts of box-type solar cooker on the cooker performance

The addition of a plane reflector to a box-type solar cooker increases the obtained cooker temperature and this depends upon the efficient orientation of the cooker. In order to find out the effect of the cooker orientation on its performance, the present analysis is carried out. A method is outlined to find out a reflector performance factor and an orientation factor that depend upon the elevation angle of the sun, the solar surface azimuth angle and the reflector tilt angle. The analysis is applied to a cooker placed at Aden (Yemen). The results indicate that with proper cooker orientation the improvement in the performance of the cooker due to the reflector reached during winter is more than 100% at lower elevation angles and is more than 60% at higher elevation angles. It is concluded that with the help of the analysis the optimum position for any place, for any day of the year and for any specific time of the day can be found.     

Efficiency enhancement of a commercial natural gas liquid recovery plant: A MINLP optimization analysis

ABSTRACT

This paper aims at modeling and optimizing a Middle East-based commercial natural gas liquid (NGL) recovery and fractionation plant, using a predictive process simulator. NGL units are known to be highly energy-intensive as steam-based heating and refrigeration-based cryogenic cooling are critical requirements for their operation. Indeed, these units govern the degree of profitability of gas plants especially during low natural gas price scenarios. As a result, this study explores the ways of improving the performance of NGL units through a deterministic optimization analysis. A steady state model of the plant is built using gPROMS process builder followed by validation using plant data to ensure the model accuracy. A mixed integer nonlinear programming optimization problem is formulated with the objective of maximizing the net revenue of the plants by means of manipulating various decision variables such as feed gas temperature, column operating pressure, feed stage location, reflux and boil up ratios subject to specific process constraints. Optimization problem is solved using outer approximation equality relaxation augmented penalty algorithm. It is determined that the process optimization yields an additional revenue of 4.1 MM USD annually due to ~22% increase in Liquefied Petroleum Gas (LPG) production, ~6% increase in Naphtha production, and ~16% reduction in steam consumption in the reboiler of the columns.     

Preparation of void-free casts from vinyl polysiloxane impressions

PURPOSE: To investigate two techniques to produce void-free casts from vinyl polysiloxane impressions. MATERIALS AND METHODS: Thirty casts prepared using a conventional technique were compared with 30 casts prepared using a technique involving syringing of stone in terms of numbers of surface voids. RESULTS: Significantly fewer surface voids were observed in the casts prepared using syringing technique. CONCLUSION: The syringing technique investigated is considered to have advantages over the conventional technique for the production of casts from vinyl polysiloxane impressions.     

Budget-bounded model-checking pushdown systems

We address the verification problem for concurrent programs modeled as multi-pushdown systems (MPDS). In general, MPDS are Turing powerful and hence come along with undecidability of all basic decision problems. Because of this, several subclasses of MPDS have been proposed and studied in the literature (Atig et al. in LNCS, Springer, Berlin, 2005; La Torre et al. in LICS, IEEE, 2007; Lange and Lei in Inf Didact 8, 2009; Qadeer and Rehof in TACAS, LNCS, Springer, Berlin, 2005). In this paper, we propose the class of bounded-budget MPDS, which are restricted in the sense that each stack can perform an unbounded number of context switches only if its depth is below a given bound, and a bounded number of context switches otherwise. We show that the reachability problem for this subclass is Pspace-complete and that LTL-model-checking is Exptime-complete. Furthermore, we propose a code-to-code translation that inputs a concurrent program \(P\) and produces a sequential program \(P'\) such that running \(P\) under the budget-bounded restriction yields the same set of reachable states as running \(P'\) . Moreover, detecting (fair) non-terminating executions in \(P\) can be reduced to LTL-Model-Checking of \(P'\) . By leveraging standard sequential analysis tools, we have implemented a prototype tool and applied it on a set of benchmarks, showing the feasibility of our translation.