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81.
In the serum of a young normal male, never transfused, a cold cytotoxic IgM antibody was found reacting exclusively with A2 homozygous cells on a French panel, as shown by population and family studies. This antibody needs about two to five times more lymphocytes or platelets to be absorbed than an immune anti-A2 of the same titre. The antigen recognized by this antibody seems to be covered by the same molecule as HLA-A2, according to redistribution experiments.  相似文献   
82.
83.
A new method is proposed to precisely and simultaneously quantify the exchangeable pool of metals in soils and to describe its reactivity at short- and long-term. It is based on multielementary Stable Isotopic Exchange Kinetics (multi-SIEK), first validated by a comparison between two monoelementary radioactive ((109)Cd*, (65)Zn*) IEK experiments, a mono- ((106)Cd) and multi- ((62)Ni, (65)Cu, (67)Zn, (106)Cd, (204)Pb) SIEK. These experiments were performed on a polluted soil located near the Zn smelter plant of Viviez (Lot watershed, France). The IEK results obtained for Cd and Zn were consistent across the experiments. (109)Cd*, (65)Zn* IEK, and multi-SIEK were then applied on 3 non- and moderate impacted soils that also provided consistent results for Cd and Zn. Within these experimental conditions, it can be concluded that no competition occurs between Cd, Zn, and the other metals during SIEK. Multi-SIEK results indicate that the isotopically exchangeable pool of Ni, Zn, and Cu are small (E(Ni), E(Zn), and E(Cu) values up to 17%) whatever the pollution degree of the soils considered in this study and whatever the duration of the interaction. On the contrary, Cd displays the highest E values (from 35% to 61% after 1 week), and E(Pb) displays a maximum value of 26% after 1 week. The multi-SIEK provides useful information on metal sources and reactivity relationship. Ni would be located in stable pedogenic phases according to its very low enrichment factor. The low E(Zn) and E(Cu) are consistent with location of Zn and Cu in stable phases coming from tailings erosion. Though Pb enrichments in soils may also be attributed to tailings particles, its larger exchangeable pool suggests that the Pb-bearing phases are more labile than those containing Zn and Cu. The high mobility of Cd in upstream soils indicates that it has been mostly emitted as reactive atmospheric particles during high temperature ore-treatment.  相似文献   
84.
Today, the con?uence of new technologies has a transformative potential never seen before. Technology's power over nature, life, and humans carries with it both an opening of astonishing possibilities, and a challenge to our wisdom. In this dynamic context, the field of applied ethics has difficulty keeping pace. Some have already concluded that applied ethics has nothing really useful to say about emerging moral con?icts related to technology. Some causes of this disappointment will be referred to in this article, together with a proposal to revise the ideas, beliefs, and practices that have contributed to strengthening this dangerous misunderstanding.  相似文献   
85.
    
Hydrogenated and phosphorus‐doped amorphous silicon carbonitride films (a‐SiCxNy:H(n)) were deposited by plasma‐enhanced chemical vapor deposition (PECVD) on crystalline silicon surface in order to explore surface passivation properties. Very silicon‐rich films yielded effective surface recombination velocities at 1 sun‐illumination as low as 3 cm s−1 and 2 cm s−1 on 1 Ω cm p‐ and n‐type crystalline silicon substrates, respectively. In order to use them as anti‐reflection coating, we increased alternatively either the carbon or nitrogen content of these films. Also, a combination of passivation and antireflective films was analyzed. Finally, we explored the passivation stability under high‐temperature steps. Copyright © 2007 John Wiley & Sons, Ltd.  相似文献   
86.
Using data from the Integrated Values Survey (IVS), the Life in Transition Survey (LiTS), and the Russia Longitudinal Monitoring Survey (RLMS), we analyse the relation between age and subjective well-being in the World Bank’s Europe and Central Asia (ECA) region and compare it to that in Western Europe. Although our results generally confirm previous studies’ findings of a U-shaped relation between subjective well-being and age for most of the lifecycle, we also find that well-being in ECA declines again after the 70s, giving rise to an S-shape relation across the entire lifespan. When controlling for socio-demographic characteristics, this pattern generally remains robust for most of our cross-sectional and panel analyses. Hence, despite significant heterogeneity in the pattern of well-being across the lifespan within the ECA region, we do not observe high levels of cross-country or cross-cohort variation.  相似文献   
87.
    
Glioblastoma display vast cellular heterogeneity, with glioblastoma stem cells (GSCs) at the apex. The critical role of GSCs in tumour growth and resistance to therapy highlights the need to delineate mechanisms that control stemness and differentiation potential of GSC. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) regulates neural progenitor cell differentiation, but its role in cancer stem cell differentiation is largely unknown. Herein, we demonstrate that DYRK1A kinase is crucial for the differentiation commitment of glioblastoma stem cells. DYRK1A inhibition insulates the self-renewing population of GSCs from potent differentiation-inducing signals. Mechanistically, we show that DYRK1A promotes differentiation and limits stemness acquisition via deactivation of CDK5, an unconventional kinase recently described as an oncogene. DYRK1A-dependent inactivation of CDK5 results in decreased expression of the stemness gene SOX2 and promotes the commitment of GSC to differentiate. Our investigations of the novel DYRK1A-CDK5-SOX2 pathway provide further insights into the mechanisms underlying glioblastoma stem cell maintenance.  相似文献   
88.
    
This paper presents the development of an analytical model for the prediction of the friction coefficient in line contacts under thermal elastohydrodynamic lubrication (TEHL). A new theoretical equation is deduced for determining the friction coefficient, taking into account the rheology of common lubricants under TEHL. This approach also considers the heat generated and its penetration into the bulk of the contacting solids. Therefore, the increase in temperature and ensuing variations in the operating conditions are determined. In order to illustrate the use of the new model and verify its accuracy, an experimental stage is performed in a tribological test rig. The predictions of the proposed model are compared with the results obtained in the test rig and other data reported in the literature for diverse lubricants, showing a good agreement in every case. © 2015 The Authors Lubrication Science published by John Wiley & Sons Ltd.  相似文献   
89.
This work correlates surface and ground water composition to the substrata, and traces how water chemistry evolves at Brazil’s largest coal mine, the Candiota Mine. The water is dominated by SO4, Fe, Ca, and Mg. A pH range of 2.7–3 in the pit lakes is attributed through chemical models to concomitant pyrite oxidation and carbonate dissolution along with slow hydrolysis of aluminosilicate minerals and buffering provided by several iron oxy-hydroxide species. The Fe deficit of the surface water relative to the expected values is mainly due to precipitation of Fe sulfate salts, hydroxysulfates, and oxyhydroxides in the waste piles and their runoff. A progressive decrease in oxygen partial pressure with increased lake depth leads to destabilization of the iron oxyhydroxides/hydroxysulfates formed near the surface, which explains their absence from the lake sediment. Although interacting with similar rock types, the groundwater has a significantly different composition than the surface water, with less salinity and a pH of 5–6.5, due to limited oxygen and its evolution in a nearly closed system that stabilizes at higher pH values, which is controlled by carbonate/bicarbonate buffering.  相似文献   
90.
    
The skin is a critical barrier that protects against damage and infection. Within the epidermis and dermis reside γδ T cells that play a variety of key roles in wound healing and tissue homeostasis. Skin-resident γδ T cells require T cell receptor (TCR) ligation, costimulation, and cytokine reception to mediate keratinocyte activity and inflammatory responses at the wound site for proper wound repair. While both epidermal and dermal γδ T cells regulate inflammatory responses in wound healing, the timing and factors produced are distinct. In the absence of growth factors, cytokines, and chemokines produced by γδ T cells, wound repair is negatively impacted. This disruption in γδ T cell function is apparent in metabolic diseases such as obesity and type 2 diabetes. This review provides the current state of knowledge on skin γδ T cell activation, regulation, and function in skin homeostasis and repair in mice and humans. As we uncover more about the complex roles played by γδ T cells in wound healing, novel targets can be discovered for future clinical therapies.  相似文献   
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