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61.
Abstracts are not published in this journal
This revised version was published online in November 2006 with corrections to the Cover Date. 相似文献
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JM Bhatavdekar DD Patel N Ghosh PR Chikhlikar TI Trivedi TP Suthar SS Doctor NG Shah DB Balar 《Canadian Metallurgical Quarterly》1997,40(7):785-790
Lanepitant is a high-affinity, selective neurokinin-1 receptor (NK-1) and is effective in the dural inflammation model of acute migraine. Lanepitant 30, 80, and 240 mg given orally was evaluated in a double-blind, placebo-controlled crossover study to determine its effect in reducing migraine pain and severity of associated symptoms. Outpatients treated four migraine headaches of moderate or severe pain intensity with study drug according to a randomization schedule. They recorded their pain intensity and severity of migraine-associated symptoms at 30, 60, 90, and 120 min. Although 53 patients were randomly allocated to a treatment sequence, only 40 patients completed all treatments. There was no statistically significant difference in improvement in migraine pain at any time for any of the treatments. Additionally, there was no change in severity of migraine-associated symptoms associated with lanepitant therapy. No adverse events could be attributed to lanepitant. Lanepitant was ineffective orally in treating acute migraine in this trial. This may be due to poor bioavailability during a migraine attack. Alternatively, the neurogenic inflammation hypothesis may not apply to migraine. 相似文献
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KB Avraham T Hasson T Sobe B Balsara JR Testa AB Skvorak CC Morton NG Copeland NA Jenkins 《Canadian Metallurgical Quarterly》1997,6(8):1225-1231
Deafness is the most common form of sensory impairment in humans. Mutations in unconventional myosins have been found to cause deafness in humans and mice. The mouse recessive deafness mutation, Snell's waltzer, contains an intragenic deletion in an unconventional myosin, myosin VI (locus designation, Myo6). The requirement for Myo6 for proper hearing in mice makes this gene an excellent candidate for a human deafness disorder. Here we report the cloning and characterization of the human unconventional myosin VI (locus designation, MYO6) cDNA. The MYO6 gene maps to human chromosome 6q13. The isolation of the human gene makes it now possible to determine if mutations in MYO6 contribute to the pathogenesis of deafness in the human population. 相似文献
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The effect of compressive deformation testedabove the M_s temperature on the martensitemorphology in Fe-Ni-C alloys has been studied.Inthe Fe-30Ni-0.12C alloy,the M_s temperature is-50℃ The cylindrical specimens werecompressively deformed at -40℃.The strain rateswere 10,20,30 and 40%.X-ray analysis andmetallographic examination showed that nostrain-induced martensite was found.After quench-ing to -53℃,some thin plates and unusualmorphologies of lenticular martensites with bentand/or broken mid-ribs were observed.In theFe-30Ni-0.34C alloy,the M_s temperature is-120℃.Compressive deformation with differentstrain rates were carried out at room temperature.After quenching to the liquid nitrogen temperature,some bent thin plate matensites(unbroken)occur-red.The transformed twins in bent plate were alsobent and nearly parallel to the γ-α'interfaces.Orientation relationship between austenite and bentmartensite has been examined by means of trans-mission electron microscope.It was proved thatthese unusual morphologies are inherent in thecompressive pre-deformed austenite. 相似文献
65.
The effect of various pHs on winged bean and soybean protein-lipid films formation, proximate composition and rehydration capacity were studied. Film can only form within a specific range of pH. Films prepared at high pHs (7.5, 9.0, 10.0 and 11.0) contained higher proportions of proteins, ash and carbohydrate but lower proportion of fat than those at pH 6.7, 2.5 and 2.0. Winged bean and soybean films were found to have different pattern of rehydration, however both tended to absorb more water at high pH. With regard to film formation efficiency, nutritional value (higher protein content) and rehydration capacity, soybean film is better than winged bean film. 相似文献
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颗粒图像测速技术在离心试验变形分析中的应用 总被引:1,自引:1,他引:0
由于颗粒图像测速技术的可遥控性和实时性,可用于离心机试验中进行土体变形测量.将土体划分为若干细小单元,通过单元的颗粒组成纹理,可以追踪单元的位移,从而确定土体的变形.以此为依据,建立一套系统来实现离心机试验中土体模型的变形监测,包括高分辨率数码相机、精确控制点、土体可识别纹理.试验后对系列图片进行数字化处理,并对实验中产生的各种误差加以修正,得到需要的变形数据.基于测速技术原理的分析,该系统的位移测量精度可以达到0.04 mm,准确度0.02 mm左右.在砂土边坡的离心试验中应用该系统,分别量测模型边坡在离心加速度增加过程中产生的变形和地下水上升过程中渗流引起的变形,试验结果规律性好,可以反映模型土体各个位置不同时刻的位移情况.表明该系统适用于离心环境中的模型试验,是研究其完整物理过程的重要工具. 相似文献