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51.
Rizia Bardhan Wenxue Chen Carlos Perez‐Torres Marc Bartels Ryan M. Huschka Liang L. Zhao Emilia Morosan Robia G. Pautler Amit Joshi Naomi J. Halas 《Advanced functional materials》2009,19(24):3901-3909
Integrating multiple functionalities into individual nanoscale complexes is of tremendous importance in biomedicine, expanding the capabilities of nanoscale structures to perform multiple parallel tasks. Here, the ability to enhance two different imaging technologies simultaneously—fluorescence optical imaging and magnetic resonance imaging—with antibody targeting and photothermal therapeutic actuation is combined all within the same nanoshell‐based complex. The nanocomplexes are constructed by coating a gold nanoshell with a silica epilayer doped with Fe3O4 and the fluorophore ICG, which results in a high T2 relaxivity (390 mM ?1 s?1) and 45× fluorescence enhancement of ICG. Bioconjugate nanocomplexes target HER2+ cells and induce photothermal cell death upon near‐IR illumination. 相似文献
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Zhehui Luo German F Alvarado Dorothy K Hatsukami Eric O Johnson Laura Jean Bierut Naomi Breslau 《Nicotine & tobacco research》2008,10(7):1223-1230
In a general population sample from the Detroit site of the Collaborative Genetic Study of Nicotine Dependence (COGEND), we tested Black-White differences in nicotine dependence, measured by "how soon after wake-up the smokers smoked their first cigarette (time to first cigarette TTFC)", and its relationship with number of cigarettes per day (CPD). Analysis was conducted on respondents who have smoked > or =100 cigarettes in lifetime and were current smokers (n = 1,442; 1,087 Whites and 355 Blacks). In univariate analysis, we found no significant race differences on time to first cigarette (chi2 = 2.9, p value = 0.41), but significant race differences on CPD (chi2 = 154.3, p<.01), both categorized by the Fagerstr?m Test of Nicotine Dependence (FTND) cutoffs. We estimated the probability of TTFC < or =30 min given CPD using probit models. The interactions between race and CPD indicated significant differences in dependence at various levels of CPD. The same probability of nicotine dependence was associated with smaller increments in CPD for Blacks than for Whites. The data support the hypothesis that the relationship between CPD and nicotine dependence as reflected in relapse varies by race, and that Black smokers are dependent at lower levels of CPD than Whites. 相似文献
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Lubick N 《Environmental science & technology》2008,42(8):2716-2717
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Risks of nanotechnology remain uncertain 总被引:1,自引:0,他引:1
Lubick N 《Environmental science & technology》2008,42(6):1821-1824
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Minami Sakamoto Tomomitsu Miyagaki Hiroaki Kamijo Tomonori Oka Hikari Boki Naomi Takahashi-Shishido Hiraku Suga Makoto Sugaya Shinichi Sato 《International journal of molecular sciences》2021,22(15)
CD147, a transmembrane glycoprotein that belongs to the immunoglobulin superfamily, and cyclophilin A (CypA), one of the binding partners of CD147, are overexpressed in tumor cells and associated with the progression of several malignancies, including both solid and hematological malignancies. However, CD147 and CypA involvement in cutaneous T-cell lymphoma (CTCL) has not been reported. In this study, we examined CD147 and CypA expression and function using clinical samples of mycosis fungoides (MF) and Sézary syndrome (SS) and CTCL cell lines. CD147 and CypA were overexpressed by tumor cells of MF/SS, and CypA was also expressed by epidermal keratinocytes in MF/SS lesional skin. Serum CypA levels were increased and correlated with disease severity markers in MF/SS patients. Anti-CD147 antibody and/or anti-CypA antibody suppressed the proliferation of CTCL cell lines, both in vitro and in vivo, via downregulation of phosphorylated extracellular-regulated kinase 1/2 and Akt. These results suggest that CD147-CypA interactions can contribute to the proliferation of MF/SS tumor cells in both a autocrine and paracrine manner, and that the disruption of CD147-CypA interactions could be a new therapeutic strategy for the treatment of MF/SS. 相似文献