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331.
Monika Hud
ov Slvka Hamuakov Eva Konkoov Rastislav Jendelovský Jana Vargov Juraj evc Peter Fedoro
ko Ondrej Soukup Jana Jano
kov Veronika Ihnatova Tom Ku
era Petr Bzonek Nikola Novakova Daniel Jun Lucie Junova Jan Korbe
ný Kamil Ku
a Mria Kourkov 《International journal of molecular sciences》2021,22(8)
A series of novel C4-C7-tethered biscoumarin derivatives (12a–e) linked through piperazine moiety was designed, synthesized, and evaluated biological/therapeutic potential. Biscoumarin 12d was found to be the most effective inhibitor of both acetylcholinesterase (AChE, IC50 = 6.30 µM) and butyrylcholinesterase (BChE, IC50 = 49 µM). Detailed molecular modelling studies compared the accommodation of ensaculin (well-established coumarin derivative tested in phase I of clinical trials) and 12d in the human recombinant AChE (hAChE) active site. The ability of novel compounds to cross the blood–brain barrier (BBB) was predicted with a positive outcome for compound 12e. The antiproliferative effects of newly synthesized biscoumarin derivatives were tested in vitro on human lung carcinoma cell line (A549) and normal colon fibroblast cell line (CCD-18Co). The effect of derivatives on cell proliferation was evaluated by MTT assay, quantification of cell numbers and viability, colony-forming assay, analysis of cell cycle distribution and mitotic activity. Intracellular localization of used derivatives in A549 cells was confirmed by confocal microscopy. Derivatives 12d and 12e showed significant antiproliferative activity in A549 cancer cells without a significant effect on normal CCD-18Co cells. The inhibition of hAChE/human recombinant BChE (hBChE), the antiproliferative activity on cancer cells, and the ability to cross the BBB suggest the high potential of biscoumarin derivatives. Beside the treatment of cancer, 12e might be applicable against disorders such as schizophrenia, and 12d could serve future development as therapeutic agents in the prevention and/or treatment of Alzheimer’s disease. 相似文献
332.
Gries Thomas Bettermann Isa Blaurock Carolin Bndgens Andreas Dittel Gzdem Emonts Caroline Gesch Valentine Glimpel Nikola Kolloch Martin Grigat Niels Lcken Henning Lwen Alexander Jacobsen Jens-Lennart Kimm Magdalena Kelbel Hannah Krger Hauke Kuo Kai-Chieh Peiner Christoph Sackmann Johannes Schwab Max 《Applied Composite Materials》2022,29(1):43-64
Applied Composite Materials - This paper provides an overview of the recent definition, technologies and current trends regarding 3D fabrics. In this paper a definition of 3D fabrics, including... 相似文献
333.
Boens N Qin W Basarić N Hofkens J Ameloot M Pouget J Lefèvre JP Valeur B Gratton E vandeVen M Silva ND Engelborghs Y Willaert K Sillen A Rumbles G Phillips D Visser AJ van Hoek A Lakowicz JR Malak H Gryczynski I Szabo AG Krajcarski DT Tamai N Miura A 《Analytical chemistry》2007,79(5):2137-2149
A series of fluorophores with single-exponential fluorescence decays in liquid solution at 20 degrees C were measured independently by nine laboratories using single-photon timing and multifrequency phase and modulation fluorometry instruments with lasers as excitation source. The dyes that can serve as fluorescence lifetime standards for time-domain and frequency-domain measurements are all commercially available, are photostable under the conditions of the measurements, and are soluble in solvents of spectroscopic quality (methanol, cyclohexane, water). These lifetime standards are anthracene, 9-cyanoanthracene, 9,10-diphenylanthracene, N-methylcarbazole, coumarin 153, erythrosin B, N-acetyl-l-tryptophanamide, 1,4-bis(5-phenyloxazol-2-yl)benzene, 2,5-diphenyloxazole, rhodamine B, rubrene, N-(3-sulfopropyl)acridinium, and 1,4-diphenylbenzene. At 20 degrees C, the fluorescence lifetimes vary from 89 ps to 31.2 ns, depending on fluorescent dye and solvent, which is a useful range for modern pico- and nanosecond time-domain or mega- to gigahertz frequency-domain instrumentation. The decay times are independent of the excitation and emission wavelengths. Dependent on the structure of the dye and the solvent, the excitation wavelengths used range from 284 to 575 nm, the emission from 330 to 630 nm. These lifetime standards may be used to either calibrate or test the resolution of time- and frequency-domain instrumentation or as reference compounds to eliminate the color effect in photomultiplier tubes. Statistical analyses by means of two-sample charts indicate that there is no laboratory bias in the lifetime determinations. Moreover, statistical tests show that there is an excellent correlation between the lifetimes estimated by the time-domain and frequency-domain fluorometries. Comprehensive tables compiling the results for 20 (fluorescence lifetime standard/solvent) combinations are given. 相似文献
334.
Nejra Omerović Mila Djisalov Kristina Živojević Minja Mladenović Jovana Vunduk Ivanka Milenković Nikola Ž. Knežević Ivana Gadjanski Jasmina Vidić 《Comprehensive Reviews in Food Science and Food Safety》2021,20(3):2428-2454
The food industry faces numerous challenges to assure provision of tasty and convenient food that possesses extended shelf life and shows long-term high-quality preservation. Research and development of antimicrobial materials for food applications have provided active antibacterial packaging technologies that are able to meet these challenges. Furthermore, consumers expect and demand sustainable packaging materials that would reduce environmental problems associated with plastic waste. In this review, we discuss antimicrobial composite materials for active food packaging applications that combine highly efficient antibacterial nanoparticles (i.e., metal, metal oxide, mesoporous silica and graphene-based nanomaterials) with biodegradable and environmentally friendly green polymers (i.e., gelatin, alginate, cellulose, and chitosan) obtained from plants, bacteria, and animals. In addition, innovative syntheses and processing techniques used to obtain active and safe packaging are showcased. Implementation of such green active packaging can significantly reduce the risk of foodborne pathogen outbreaks, improve food safety and quality, and minimize product losses, while reducing waste and maintaining sustainability. 相似文献
335.
Radoslava Pravilović Tamara Janković Milica Veljković Branislav Todić Milica Simović Dejan Bezbradica Nikola Nikačević 《American Institute of Chemical Engineers》2023,69(9):e18122
A new micro-kinetic model of the enzyme-catalyzed synthesis of fructo-oligosaccharides (FOS) was developed. A commercial enzyme mixture Pectinex® Ultra SP-L derived from Aspergillus aculeatus was used. A variety of initial enzyme concentrations (1–5 vol%) and sucrose concentrations (400–600 g/L) were experimentally investigated and included in kinetic modeling. Several variations of kinetic mechanisms and corresponding models have been examined. A hybrid genetic algorithm was used to predict the kinetic parameters simultaneously for all experimental data. The best fitting model has been adopted, and with an average error of 13.34%, it describes the experimental data very well. The influence of initial concentrations on the conversion of sucrose and production of FOS is being carefully investigated. It was shown that the initial sucrose concentration significantly affects the highest level of FOS concentration, but the enzyme concentration controls the time at which maximum is reached as well as the rate of FOS decomposition. 相似文献
336.
Ivan Javni Olivera Bilić Nikola Bilić Zoran S. Petrović Eric A. Eastwood Fan Zhang Jan Ilavský 《应用聚合物科学杂志》2015,132(47)
Isosorbide, a renewable diol derived from starch, was used alone or in combination with butane diol (BD) as the chain extender in two series of thermoplastic polyurethanes (TPU) with 50 and 70% polytetramethylene ether glycol (PTMEG) soft segment concentration (SSC), respectively. In the synthesized TPUs, the hard segment composition was systematically varied in both series following BD/isosorbide molar ratios of 100 : 0; 75 : 25; 50 : 50; 25 : 75, and 0 : 100 to examine in detail the effect of chain extenders on properties of segmented polyurethane elastomers with different morphologies. We found that polyurethanes with 50% SSC were hard elastomers with Shore D hardness of around 50, which is consistent with assumed co‐continuous morphology. Polymers with 70% SSC displayed lower Shore A hardness of 74–79 (Shore D around 25) as a result of globular hard domains dispersed in the soft matrix. Insertion of isosorbide increased rigidity, melting point and glass transition temperature of hard segments and tensile strength of elastomers with 50% SSC. These effects were weaker or non‐existent in 70% SSC series due to the short hard segments and low content of isosorbide. We also found that the thermal stability was lowered by increasing isosorbide content in both series. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 42830. 相似文献
337.
A subthreshold current‐sensing ΣΔ modulator for low‐voltage and low‐power sensor interfaces
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Nikola Katic Ibrahim Kazi Armin Tajalli Alexandre Schmid Yusuf Leblebici 《International Journal of Circuit Theory and Applications》2015,43(11):1597-1614
A continuous‐time (CT) ΣΔ modulator for sensing and direct analog‐to‐digital conversion of nA‐range (subthreshold) currents is presented in this work. The presented modulator uses a subthreshold technique based on subthreshold source‐coupled logic cells to efficiently convert subthreshold current to digital code without performing current‐to‐voltage conversion. As a benefit of this technique, the current‐sensing CT ΣΔ modulator operates at low voltage and consumes very low power, which makes it convenient for low‐power and low‐voltage current‐mode sensor interfaces. The prototype design is implemented in a 0.18 µm standard complementary metal‐oxide semiconductor technology. The modulator operates with a supply voltage of 0.8 V and consumes 5.43 μW of power at the maximum bandwidth of 20 kHz. The obtainable current‐sensing resolution ranges from effective number of bits (ENOB) = 7.1 bits at a 5 kHz bandwidth to ENOB = 6.5 bits at a 20 kHz bandwidth (ENOB). The obtained power efficiency (peak FoM = 1.5 pJ/conv) outperforms existing current‐mode analog‐to‐digital converter designs and is comparable with the voltage‐mode CT ΣΔ modulators. The modulator generates very low levels of switching noise thanks to CT operation and subthreshold current‐mode circuits that draw a constant subthreshold current from the voltage supply. The presented modulator is used as a readout interface for sensors with current‐mode output in ultra low‐power conditions and is also suitable to perform on‐chip current measurements in power management circuits. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
338.
Effects of high temperatures and drought during anthesis and grain filling period on wheat processing quality and underlying gluten structural changes
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339.
为获取保留图像信息较完好的差异图并得到更好的变化检测结果,提出一种基于自适应脉冲耦合神经网络(PC‐NN)和改进Chan‐Vese (C‐V)模型的非监督的不同时相遥感图像的变化检测算法。用差值法、比值法对两幅遥感图像进行差异图获取;用自适应PCNN图像融合算法对两幅差异图进行融合,获取保留图像信息较好的差异图;用基于改进C‐V模型的分割算法对融合后的差异图进行分割,得到变化检测结果图。实验结果表明,该算法具有很好的变化检测效果,总检测精度较高。 相似文献
340.
Magdalena Krystyjan Gohar Khachatryan Karen Khachatryan Anna Konieczna-Molenda Anna Grzesiakowska Marta Kuchta-Gadysz Agnieszka Kawecka Wiktoria Grzebieniarz Nikola Nowak 《International journal of molecular sciences》2022,23(11)
This study describes functional properties of bionanocomposites consisting of starch/chitosan/graphene oxide (GO) obtained using the green synthesis method, such as water-barrier and optical properties, as well as the rate of degradation by enzymatic and acid hydrolysis. The toxicity of the composites and their effects on the development of pathogenic microflora during storage of meat food products was also investigated. Although the results showed that the barrier properties of the composites were weak, they were similar to those of biological systems. The studies carried out confirmed the good optical properties of the composites containing chitosan, which makes it possible to use them as active elements of packaging. The susceptibility of starch and chitosan films to enzymatic and acid hydrolyses indicates their relatively high biodegradability. The lack of toxicity and the high barrier against many microorganisms offer great potential for applications in the food industry. 相似文献