A flexible,object-centric approach for business process modelling

Mainstream business process modelling techniques often promote a design paradigm wherein the activities that may be performed within a case, together with their usual execution order, form the backbone on top of which other aspects are anchored. This Fordist paradigm, while effective in standardised and production-oriented domains, breaks when confronted with processes in which case-by-case variations and exceptions are the norm. We contend that the effective design of flexible processes calls for a substantially different modelling paradigm. Motivated by requirements from the human services domain, we explore the hypothesis that a framework consisting of a small set of coordination concepts, combined with established object-oriented modelling principles, provides a suitable foundation for designing highly flexible processes. Several human service delivery processes have been designed using this framework, and the resulting models have been used to realise a system to support these processes in a pilot environment.     

Development of active matrix LCD for use in high‐resolution adaptive headlights

Conventional adaptive driving beam headlamps are limited in achieving still higher quantities of switchable pixels by the number of LEDs and movable elements needed. In this paper, it is shown that by integrating an active matrix liquid crystal display module, it is possible to realize fully adaptive high‐resolution headlights without mechanical elements and a finite number of LED with 30 k switchable pixels.     

First experiences with the Polish Optical Internet

The paper describes the new development programme of the Polish information infrastructure. The programme, called in Polish PIONIER: (English—PIONEER) Polish Optical Internet, Advanced Applications, Services and Technologies for the Information Society, has been proposed to the Polish State Committee for Scientific Research and has been accepted. The aim of the programme is to create an advanced infrastructure together with tools, services and applications available to the entire scientific community and eventually to government and local administrations as well as society in general. Services and applications are expected to appear as selected pilot realizations in order to verify deployed technologies. Some of the pilot realizations and testbeds are also presented in the paper.     

Beschlüsse vom 13./14. November 2008 in Wiesbaden Düsseldorfer Kreis

Dokumentation

Beschlüsse vom 13./14. November 2008 in Wiesbaden Düsseldorfer Kreis Obserte Aufsichtsbeh?rden für den Datenschutz im nicht?ffentlichen Bereich     

Proteomics in ocular fluids

The focus of this article is to review recent techniques in proteomic analysis of ocular fluids. These fluids include tears, aqueous humor, and vitreous, they will also be compared to serum analysis. Furthermore, we attempt to summarize some disease correlated biomarkers in ocular fluids that were discovered through different proteomic techniques in eye diseases like dry eye, glaucoma, age-related macular degeneration, uveitis, or diabetic retinopathy. This review is trying to point out the importance of these biomarkers for clinical applications.     

An efficient method to detect calcitonin mRNA in normal and neoplastic rat C-cells (medullary thyroid carcinoma) by in situ hybridization using a digoxigenin-labeled synthetic oligodeoxyribonucleotide probe

We report here an efficient and rapid method for the specific detection of calcitonin in tumor C-cells of medullary thyroid carcinoma (MTC). This occasionally aggressive tumor arises from the endocrine thyroid C-cells. Its principal marker is calcitonin, the predominant C-cell secretion, which is detected in patients and in our animal model by radioimmunoassay of the plasma, as well as by immunohistochemistry of thyroid tissues. Although calcitonin is easily detectable in normal C-cells, its content is greatly reduced in tumor cells owing to the disappearance of the secretory granules that store the mature peptide. This finding suggests cell dedifferentiation correlated with an increasing aggressivity of the tumor. We therefore developed a rapid detection of calcitonin mRNA by in situ hybridization on routine paraffin sections, using a synthetic oligodeoxyribonucleotide probe labeled with digoxigenin-dUTP. The reaction was detected with an anti-digoxigenin antibody conjugated with alkaline phosphatase, and the enzyme catalyzed the appearance of a dark blue color. The signal was exclusively restricted to the normal, hyperplastic, and tumor C-cells. It was specific, as increasing concentrations of the unlabeled oligonucleotide led to progressive disappearance of the reaction. Its sensitivity was slightly diminished as compared with corresponding frozen sections, but the intensity of the signal was quite acceptable. High levels of calcitonin mRNA were found in all normal and hyperplastic C-cells. They were increased in most of the tumor MTC cells, which did not correlate with the amount of intracellular peptide stores but explained the abnormally high basal levels of circulating calcitonin of the tumor-bearing rats. ISH is therefore of greater value than ICC for an early anatomopathological detection of this tumor. Our data show that the tumor cells are not "dedifferentiated." They only lack the granular compartment storing the mature peptide before exocytosis, but CT biosynthesis and the rest of the secretory process seem to be complete. Our results suggest that factors expressed in malignant C-cells affect basic cell mechanisms involved in the storage of the mature calcitonin, rather than the expression of the CALC gene.     

Raman microprobe analysis of preforms and optical fibers

The concentration profile of various dopants (germanium, phosphorus, and fluorine) in preforms and optical fibers has been obtained with a Raman microprobe. A 2-microm spatial resolution was achieved. In the case of germanium and phosphorus, the results agree quite well with those obtained with an electron microprobe. Raman spectroscopy easily detects fluorine. From measurements of various F-doped samples, diffusion of fluorine in undoped and doped silica is suggested.     

Moderne Elektronenstrahltechnologien zum Fügen und zur Randschichtbehandlung. Modern Electron Beam Technologies for Soldering and Surface Treatment

A new generation of beam deflection technique is the basis for the development of electron beam (EB) technologies, which are not realisable with conventional methods. A high frequency 3D‐beam deflection makes possible multi‐field, multi‐pool and multi‐process technologies for EB welding und EB surface treatment, which result in a clear higher productivity and new combinations of properties.