Characterization of minocycline loaded chitosan/polyethylene glycol/glycerol blend films as antibacterial wound dressings

Wound care has been a challenging subject for medical teams and researchers. Bacterial infections are one of the most serious complications in injured skins that often affect healing process. Antibacterial wound dressings can be used to facilitate wound healing process. The purpose of this study is to fabricate chitosan (Chito)/polyethylene glycol (PEG) antibacterial wound dressing doped with minocycline, and to evaluate the influence of composition ratio on the blending properties of the films. To improve the mechanical properties of these films, we examined various amounts of glycerol as a plasticizer. Moreover, we investigated morphological and mechanical aspects, water uptake, degradation, water vapor transmission and wettability properties of the films prepared with various ratios of Chito/PEG/Gly. Assessment of mechanical properties revealed that film containing 80:20 ratio Chito/PEG with 40 PHR Gly content exhibits the highest ultimate tensile strength and elongation at break (9.74 MPa and 45.73% respectively). Furthermore, results demonstrated that upon increasing PEG and Gly contents, degradability and hydrophilicity of the films increased whereas water uptake decreased. Water vapor transmission rate of the films was close to the range of 530–1200 g/m²d, indicating that the as formed films are possible candidates for dressing low exudate wounds or burns. Minocycline loaded films exhibited a biphasic drug release profile and it was more effective on gram-positive bacteria than on gram-negative bacteria. The polymeric film with the highest amount of loaded drug (2%) exhibited insignificant cytotoxicity (88%) against normal fibroblast cell line.     

What can possibly go wrong? Anticipatory work in space operations

This paper explores how different forms of anticipatory work contribute to reliability in high-risk space operations. It is based on ethnographic field work, participant observation and interviews supplemented with video recordings from a control room responsible for operating a microgravity greenhouse at the International Space Station (ISS). Drawing on examples from different stages of a biological experiment on the ISS, we demonstrate how engineers, researchers and technicians work to anticipate and proactively mitigate possible problems. Space research is expensive and risky. The experiments are planned over the course of many years by a globally distributed network of organizations. Owing to the inaccessibility of the ISS, every trivial detail that could possibly cause a problem is subject to scrutiny. We discuss what we label anticipatory work: practices constituted of an entanglement of cognitive, social and technical elements involved in anticipating and proactively mitigating everything that might go wrong. We show how the nature of anticipatory work changes between planning and the operational phases of an experiment. In the planning phase, operators inscribe their anticipation into technology and procedures. In the operational phase, we show how troubleshooting involves the ability to look ahead in the evolving temporal trajectory of the ISS operations and to juggle pre-planned fixes along these trajectories. A key objective of this paper is to illustrate how anticipation is shared between humans and different forms of technology. Moreover, it illustrates the importance of including considerations of temporality in safety and reliability research.     

Objective evaluation of speech dysfluencies using wavelet packet transform with sample entropy

Dysfluency and stuttering are a break or interruption of normal speech such as repetition, prolongation, interjection of syllables, sounds, words or phrases and involuntary silent pauses or blocks in communication. Stuttering assessment through manual classification of speech dysfluencies is subjective, inconsistent, time consuming and prone to error. This paper proposes an objective evaluation of speech dysfluencies based on the wavelet packet transform with sample entropy features. Dysfluent speech signals are decomposed into six levels by using wavelet packet transform. Sample entropy (SampEn) features are extracted at every level of decomposition and they are used as features to characterize the speech dysfluencies (stuttered events). Three different classifiers such as k-nearest neighbor (kNN), linear discriminant analysis (LDA) based classifier and support vector machine (SVM) are used to investigate the performance of the sample entropy features for the classification of speech dysfluencies. 10-fold cross validation method is used for testing the reliability of the classifier results. The effect of different wavelet families on the classification performance is also performed. Experimental results demonstrate that the proposed features and classification algorithms give very promising classification accuracy of 96.67% with the standard deviation of 0.37 and also that the proposed method can be used to help speech language pathologist in classifying speech dysfluencies.     

Effect of kinesthetic and tactile haptic feedback on the quality of experience of edutainment applications

Haptic technologies and applications have received enormous attention in the last decade. The incorporation of haptic modality into multimedia applications adds excitement and enjoyment to an application. It also adds a more natural feel to multimedia applications, that otherwise would be limited to vision and audition, by engaging as well the user’s sense of touch, giving a more intrinsic feel essential for ambient intelligent applications. However, the improvement of an application’s Quality of Experience (QoE) by the addition of haptic feedback is still not completely understood. The research presented in this paper focuses on the effect of haptic feedback and what it potentially adds to the experience of the user as opposed to the traditional visual and auditory feedback. In essence, it investigates certain issues regarding stylus-based haptic education applications and haptic-enhanced entertainment videos. To this end, we used two haptic applications: the haptic handwriting learning tool to experiment with force feedback haptic interaction and the tactile YouTube application for tactile haptic feedback. In both applications, our analysis shows that the addition of haptic feedback will increase the QoE in the absence of fatigue or discomfort for this category of applications. This implies that the incorporation of haptic modality (both force feedback as well as tactile feedback) has positively contributed to the overall QoE for the users.     

Multiple responses analysis and modeling of Fenton process for treatment of high strength landfill leachate

Landfill leachate is one of the most recalcitrant wastes for biotreatment and can be considered a potential source of contamination to surface and groundwater ecosystems. In the present study, Fenton oxidation was employed for degradation of stabilized landfill leachate. Response surface methodology was applied to analyze, model and optimize the process parameters, i.e. pH and reaction time as well as the initial concentrations of hydrogen peroxide and ferrous ion. Analysis of variance showed that good coefficients of determination were obtained (R2 > 0.99), thus ensuring satisfactory agreement of the second-order regression model with the experimental data. The results indicated that, pH and its quadratic effects were the main factors influencing Fenton oxidation. Furthermore, antagonistic effects between pH and other variables were observed. The optimum H2O2 concentration, Fe(II) concentration, pH and reaction time were 0.033 mol/L, 0.011 mol/L, 3 and 145 min, respectively, with 58.3% COD, 79.0% color and 82.1% iron removals.     

New Hybrid Access Method for Femtocell through Adjusting QoS

The increasing number of mobile users raises issues about coverage extension in some areas such as rural zones, indoor or underground locations： one of suggestion solution to accommodate this growing of mobile user is femtocell. Femtocell have been attracting considerable attention in mobile communications, it is a small base station that install to improve the indoor coverage of a given cellular and to enhance user＇s capacity. Call admission control and resource allocation infemtocell＇s hybrid mode are an essential performance promotion issue. Developing methods for femtocell utilization is very comparative nowadays. The two major limitations of wireless communication are capacity and range. The main contribution of our paper is developing resource allocation scheme that can manage the femocell resources between subscriber （femtocell user） and non-subscriber （macrocell user in order to maximizing the system utilizations, we provide a mechanism that leads to serve more users by admitting more subscribers basing on adjusting QoS of the connected users.     

Buoyancy convection in a cavity with mutually orthogonal heated plates

Buoyancy driven convection in a square cavity induced by two mutually orthogonal arbitrarily placed heated thin plates is studied numerically under isothermal and isoflux boundary conditions. The flow is assumed to be two-dimensional. The coupled governing equations were solved by the finite difference method using the Alternating Direction Implicit technique and Successive Over Relaxation method. The steady state results are depicted in terms of streamline and isotherm plots. It is found that the resulting convection pattern is stronger for the isothermal boundary condition. A better overall heat transfer can be achieved by placing one of the plates far away from the center of the cavity for isothermal boundary condition and near the center of the cavity for isoflux boundary condition.     

Design and modelling of ultrasonic tomography for two-component high-acoustic impedance mixture

This paper describes the design and modelling of ultrasonic tomography for two-component high-acoustic impedance mixture such as liquid/gas and oil/gas flow which commonly found in chemical columns and industrial pipelines. The information obtained through this research has proven to be useful for further development of ultrasonic tomography. This includes acquiring and processing ultrasonic signals from the transducers to obtain the information of the spatial distributions of liquid and gas in an experimental column. Analysis on the transducers’ signals has been carried out to distinguish between the observation time and the Lamb waves. The information obtained from the observation time is useful for further development of the image reconstruction.     

A multi-objective strategy in genetic algorithms for gene selection of gene expression data

A microarray machine offers the capacity to measure the expression levels of thousands of genes simultaneously. It is used to collect information from tissue and cell samples regarding gene expression differences that could be useful for cancer classification. However, the urgent problems in the use of gene expression data are the availability of a huge number of genes relative to the small number of available samples, and the fact that many of the genes are not relevant to the classification. It has been shown that selecting a small subset of genes can lead to improved accuracy in the classification. Hence, this paper proposes a solution to the problems by using a multiobjective strategy in a genetic algorithm. This approach was tried on two benchmark gene expression data sets. It obtained encouraging results on those data sets as compared with an approach that used a single-objective strategy in a genetic algorithm. This work was presented in part at the 13th International Symposium on Artificial Life and Robotics, Oita, Japan, January 31–February 2, 2008