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11.
The voltage-gated proton channel, Hv1, also termed VSOP, was discovered in 2006. It has long been suggested that proton transport through voltage-gated proton channels regulate reactive oxygen species (ROS) production in phagocytes by counteracting the charge imbalance caused by the activation of NADPH oxidase. Discovery of Hv1/VSOP not only confirmed this process in phagocytes, but also led to the elucidation of novel functions in phagocytes. The compensation of charge by Hv1/VSOP sustains ROS production and is also crucial for promoting Ca2+ influx at the plasma membrane. In addition, proton extrusion into neutrophil phagosomes by Hv1/VSOP is necessary to maintain neutral phagosomal pH for the effective killing of bacteria. Contrary to the function of Hv1/VSOP as a positive regulator for ROS generation, it has been revealed that Hv1/VSOP also acts to inhibit ROS production in neutrophils. Hv1/VSOP inhibits hypochlorous acid production by regulating degranulation, leading to reduced inflammation upon fungal infection, and suppresses the activation of extracellular signal-regulated kinase (ERK) signaling by inhibiting ROS production. Thus, Hv1/VSOP is a two-way player regulating ROS production. Here, we review the functions of Hv1/VSOP in neutrophils and discuss future perspectives. 相似文献
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A method of measurement of solids holdup in a three-phase reactor by analyzing the shape and the phase lag or lead of an ultrasonic wave has been proposed. The solids holdup in a solids-dilute three-phase fluidized bed could be measured without being affected by the presence of gas bubbles. The experimental values of solids axial dispersivity measured by the ultrasonic technique are in reasonable agreement with an empirical correlation of previous data obtained by other methods. The possibility of the application of the ultrasonic technique to the measurement of solids holdup in a three-phase fluidized bed has been suggested. 相似文献
14.
Yasuro Ikuma Eriko Shimada Nobuko Okamura 《Journal of the American Ceramic Society》2005,88(2):419-423
An extensive X-ray study of CeO2 –Nd2 O3 solid solutions was performed, and the densities of solid solutions containing various concentrations of NdO1.5 were measured using several techniques. Solid solutions containing 0–80 mol% NdO1.5 were synthesized by coprecipitation from Ce(NO3 )3 and Nd(NO3 )3 aqueous solutions, and the coprecipitated samples were sintered at 1400°C. A fluorite structure was observed for CeO2 –NdO1.5 solid solutions with 0–40 mol% NdO1.5 , which changed to a rare earth C-type structure at 45–75 mol% NdO1.5 . The change in the lattice parameters of CeO2 –NdO1.5 solid solutions, when plotted with respect to the NdO1.5 concentration, showed that the lattice parameters followed Vegard's law in both the fluorite and rare earth C-type regions. The maximum solubility limit for NdO1.5 in CeO2 solid solution was approximately 75 mol%. The relationship between the density and the Nd concentration indicated that the defect structure followed the anion vacancy model over the entire range (0–70 mol% NdO1.5 ) of solid solution. 相似文献
15.
Three kinds of trapped radicals are observed in poly(maleic anhydride) (Poly-MAH) which were prepared by the use of radical initiators such as AIBN or BPO. It was found that these radicals were transformed to the active species so as to initiate the cationic polymerization. The structure of these radicals was studied by the ESR and the kinetic analysis of MAH polymerization in the presence of various additives. 相似文献
16.
We report experimental results on enhanced backscattering from a plane mirror that is viewed through polymer-film-dispersed nematic liquid crystals. The distribution of the averaged intensity of the light reflected from the mirror placed behind the polymer film is investigated with an image-processing system when a Gaussian beam wave is incident. The enhanced light peak is observed in an incident beam direction, the result of which is predicted by a theory based on the circular Gaussian statistic random-phase-screen model. We pay attention to the enhancement dependence on parameters such as the distance between the polymer film and the flat mirror. The observed result is similar to a previous study by Jakeman et al. in which a random diffusive glass plate was used as a random-phase screen [J. Phys. D 21, 32 (1988)]. 相似文献
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The suppression of the active-oxidation of Si-C fibers (Hi-Nicalon) by carbon or silica coating were investigated at 1773 K under a reduced pressure of 1.32 Pa, through mass change determination, XRD analysis, resistivity measurement, SEM observation and tensile test. The coating of carbon and silica were conducted by heat-treating at 1773 K in CO-CO2 gas mixtures. After exposure under a reduced pressure, the carbon coating formed in pure CO gas remained almost perfect and the retained strength of 1.7 GPa was nearly identical to that in the as-heat treated state. On the other hand, the carbon coatings formed under other conditions and all the silica coatings were completely lost during vacuum exposure. The retained strengths were in the range of 0 to 1.6 GPa. The silica film was found to be ineffective for suppressing the active-oxidation during vacuum exposure. 相似文献
20.
We prove that the quantum relative entropy is a rate function in large deviation principle. Next, we define information criteria for quantum states and estimate the accuracy of the use of them. Most of the results in this paper are essentially based on Hiai-Ohya-Tsukada theorem.
相似文献