Synthesis and electrical properties of sodium bismuth niobate Na0.5Bi2.5Nb2O9

The crystal structure of Na_0.5Bi_2.5Nb₂O₉ was refined from its powder X-ray diffraction (XRD) data. Sodium bismuth niobate at 23 °C is orthorhombic, A2₁am, with a=5.4998(3) Å, b=5.4602(2) Å, c=24.952(1) Å, and Z=4. The piezoelectric properties were investigated using the dense bulk ceramics. The electromechanical coupling coefficients (k_ij) and electrical quality factors (Q_m) are k₃₁=3.2%, k_t=10.0%, and Q_m=3800. Single crystals were also grown from stoichiometric melts using a slow cooling technique. The dielectric and ferroelectric properties of the crystal indicates that a spontaneous polarization clearly occurs in the crystallographic a-b plane.     

Upregulation of angiotensin-converting enzyme during the healing process after injury at the site of percutaneous transluminal coronary angioplasty in humans

BACKGROUND: Balloon injury models in rat have shown enhanced expression of ACE in the developing neointima. However, neointimal lesions in human coronary arteries are complex due to atherosclerosis and different types of wall laceration. This study was designed to investigate whether ACE is present in the neointima of humans, including patients with restenosis after percutaneous transluminal coronary angioplasty (PTCA). METHODS AND RESULTS: Thirty-seven sites with angioplasty injury, obtained at autopsy, were studied using immunocytochemical techniques. Sites with injury limited to a fibrous plaque and those with injury extending into the media (<2 months after PTCA) showed fibrocellular repair tissue composed mainly of smooth muscle cells that were distinctly positive for ACE. In cellular reactions at the site of injury limited to the atheromatous plaque (<2 months after PTCA), the expression of ACE appeared first in accumulated macrophages; once smooth muscle cells appeared in the repair tissue, they also expressed ACE. At a later stage (3 months after PTCA), the number of cells with ACE expression decreased markedly; from 7 months on, ACE was no longer expressed within the repair tissue. Basically, there were no differences with regard to ACE expression during the healing process after PTCA between segments with and those without angiographic evidence of restenosis. CONCLUSIONS: These results show that PTCA injury in humans results in upregulation of ACE at sites of active repair and, therefore, ACE could play an important role as one of the mediators of the healing process after PTCA.     

Decrease in glomerular filtration rate in Japanese patients with type 2 diabetes is linked to atherosclerosis

OBJECTIVE: We assessed the effects of atherosclerosis on the glomerular filtration rate (GFR) in patients with type 2 diabetes and who had micro- or normoalbuminuria. RESEARCH DESIGN AND METHODS: A total of 61 Japanese patients with type 2 diabetes were recruited from inpatients of Osaka City University Hospital. They ranged in age from 40 to 69 years (28 men and 33 women). Each subject collected a 24-h urine sample for quantitative analysis of albumin. Absence of albuminuria was defined as a urinary albumin excretion level of <30 mg/24 h (n = 36) and microalbuminuria as a level of 30-300 mg/24 h. The GFR was estimated using 99mTc diethylenetriamine pentaacetic renogram method. As indexes of atherosclerosis, we measured the intimal-medial thickness (IMT) and distensibility of the carotid artery using high-resolution B-mode ultrasonagraphy and an echo-tracking system. We measured the resistance index (RI) of the renal interlobar arteries by pulsed Doppler sonography. RESULTS: The clinical characteristics of type 2 diabetic patients with and without microalbuminuria did not differ except for duration of diabetes, which was longer in the patients with microalbuminuria. GFR also did not differ between the patients with and without microalbuminuria. GFR was significantly correlated with the patient's age (r = -0.256, P < 0.05), carotid IMT (r = -0.326, P < 0.05), carotid stiffness beta (r = -0.449, P < 0.001), and renal arterial RI (r = -0.365, P < 0.05). In multiple regression analysis, independent factors associated with GFR were carotid IMT (R2 = 0.108, P = 0.0102), carotid stiffness beta (R2 = 0.208, P = 0.0003), and renal artery RI (R2 = 0.130, P = 0.0043). CONCLUSIONS: The decline in GFR in type 2 diabetic patients in the early stages of nephropathy may be due in part to atherosclerosis.     

Stimulation of phosphorylation of mitogen-activated protein kinase by 1alpha,25-dihydroxyvitamin D3 in promyelocytic NB4 leukemia cells: a structure-function study

The conformations of isolated rabbit fast myosin light chains (LCs) were modified using trifluoperazine (TFP), the hydrophobic calmodulin inhibitor. CD spectroscopy showed that TFP altered secondary structural content of the LCs, with half-maximal effects at TFP concentrations of approximately 14-50 microM, which is within the range required to alter muscle fiber contraction in both agonistic and antagonistic ways [Kurebayashi, N. & Ogawa, Y. (1988) J. Physiol. 403, 407-424]. EPR spectroscopy provided structural information from paramagnetic probes on C-terminal domain surfaces. In the absence of TFP, tauR (rotational correlation time) was 1.6 ns for both alkali light chains (ALCs) and 1.8 ns for light chain 2 (LC2). This was faster than expected for proteins of this size (approximately 10 ns). TFP progressively recruited the probes into populations with tauR sevenfold to 12-fold slower, with half-maximal effects at a TFP concentration of approximately 370-800 microM. The differences probably indicate that CD spectroscopy detects changes in protein conformation due to 'specific' TFP binding at the LC hydrophobic core, while less specific binding at higher TFP concentrations is required to effect conformational changes on the protein surfaces near the paramagnetic probes. TFP binding was generally not cooperative. Comparative sequence analysis between calmodulin, troponin C, and myosin LCs indicated considerable conservation between residues expected to bind TFP.     

Development of automatic fault point locating and sectional isolating system for power distribution line

This paper describes the development of the Automatic Fault Point Locating and Sectional Isolating System. This system locates a single-line-to-ground fault point at each pole by using ground-current sensors, and isolates the faulted section by controlling pole switches with no outage of unfaulted sections. The ground-current sensor is connected to the line between allied ground terminals of pole devices and grounded conductor. It detects a ground fault current of more than 0.64 amperes that is determined so as to avoid an unexpected operation by stray current, but to detect the fault current accurately, and sends out an emergency signal with time delay of 0.1 s. Sectional isolation starts when both the emergency signal from the sensor and relay operation signals from a substation are received and ends within a feeder circuit-breaker tripping time of 1.5 s.     

Suppression of Active Oxidation of Polycarbosilane-Derived Silicon Carbide Fibers by Preoxidation at High Oxygen Pressure

Three types of polycarbosilane-derived SiC fibers (Nicalon, Hi-Nicalon, and Hi-Nicalon S) with different SiO₂ film thicknesses ( b ) were subjected to exposure tests at 1773 K in an argon-oxygen gas mixture with an oxygen partial pressure of 1 Pa. The suppression effect of a SiO₂ coating on active oxidation was examined through TG, XRD analysis, SEM observation, and tensile tests. All the as-received fibers were oxidized in the active-oxidation regime. The mass gain and the SiO₂ film development showed a suppression of active oxidation at b values of ≧0.070 μm for Nicalon, ≧0.013 μm for Hi-Nicalon, and ≧0.010 μm for Hi-Nicalon S fibers. Considerable strength was retained in the SiO₂-coated fibers. For Hi-Nicalon fibers, the retained strength was 71%–90% of the strength in the as-received state (2.14–2.69 GPa).     

Experiments and Predictions of Soil Desaturation by Air-Injection Technique and the Implications Mediated by Multiphase Flow Simulation

Measures preventing an earthquake-induced soil liquefaction are of significant importance to mitigate the liquefaction hazards. An air-injection technique may be a simple, inexpensive method - this leads the saturated soils to the desaturated by injecting pressurized air, resulting in a higher liquefaction strength and lower susceptibility. The objective of this study is to investigate the evolution of desaturation process during air injection into saturated soil deposits and verify the validity of a multiphase flow simulator if it is capable of being applied for predicting the process as well as the distribution of degree of saturation after the air injection ceased. In this study simplified model tests that simulate the air injection into saturated soils using air-injection probes, are conducted using two different sizes of soil containers. The experiments using the small container are aimed to examine the nominal rates and magnitudes of the soil desaturation driven by air injection, whilst those with the large container are performed to obtain not only the rates and magnitudes but also the distributions of the desaturated zones within the soil. The results obtained indicate, although clearly depending on the physical properties of targeted soils, that the evolution of desaturation is strongly controlled by the air pressures injected and the soil permeabilities. Numerical analyses are also conducted using a multiphase flow simulator to describe the evolution of the soil desaturation, and to examine the applicability of the model as a prediction tool enabling an evolution of desaturation in situ to be followed with time and space. Predictions show a relatively good agreement with the experimental measurements regarding the rates, magnitudes, and distribution of desaturation specifically for the small-container experiments although predictions of desaturated domain slightly overestimate the measurements for the large-container experiments. Thus, this study indicates that the numerical model described is applicable to field problems when the soil properties in terms of flow transport are well-constrained.     

Polymerization of trithiane

The catalytic solid-state polymerization of trithane to polythiomethylene has been studied. The polymerization can be initiated by wide varieties of substances such as metal salts, halogen, and active organic halides. The polymerization proceeds in solid-state without topochemical process. The catalytic irreversible degradation of polythiomethylene to dimethyl sulfide and carbon disulfide has been observed.