Reduction by cefodizime of the pulmonary inflammatory response induced by heat-killed Streptococcus pneumoniae in mice

It has recently become apparent that overwhelming inflammatory reactions contribute to the high mortality rate associated with pneumococcal infection in immunocompetent hosts. Cefodizime (CEF) is an antibiotic that seems to be endowed with immunomodulating properties. To investigate the influence of CEF on the pulmonary inflammatory response induced by Streptococcus pneumoniae, we infected mice with repeated intranasal inoculations of 10(7) CFU of heat-killed fluorescein isothiocyanate-labeled bacteria, which are insensitive to the killing properties of the drug. CEF downregulated but did not abolish the strong polymorphonuclear leukocyte (PMN) recruitment induced by S. pneumoniae. PMN recruitment was not primarily mediated by leukotriene B4 in this model. The drug did not interfere with intrinsic mechanisms of phagocytosis by PMNs and alveolar macrophages. CEF totally abrogated the pneumococcus-induced tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) secretion in bronchoalveolar lavage fluid. The drug also prevented IL-6 release in lung homogenates and partly inhibited TNF-alpha, but it did not interfere with IL-1alpha secretion in the lungs of infected mice. The fractional and selective downregulation of inflammatory cells and cytokines by CEF suggests cell-specific and intracellular specific mechanisms of interaction of the drug. The immunomodulatory properties of CEF may help restrain excessive inflammatory reactions, thus contributing to the reported good clinical efficacy of the drug against lower respiratory tract infections.     

Using time-driven activity-based costing to manage digital forensic readiness in large organisations

A digital forensic readiness (DFR) programme consists of a number of activities that should be chosen and managed with respect to cost constraints and risk. Traditional cost systems, however, can not provide the cost of individual activities. This makes it difficult or impossible for organisations to consider cost when making decisions about specific activities. In this paper we show that the relatively new cost system, time-driven activity-based costing (TDABC), can be used to determine the cost of implementing and managing activities required for DFR. We show through analysis and simulation that the cost information from a TDABC model can be used for such decisions. We also discuss some of the factors that ought to be considered when implementing or managing the use of TDABC in a large organisation.     

A theory of self-calibration of a moving camera

There is a close connection between the calibration of a single camera and the epipolar transformation obtained when the camera undergoes a displacement. The epipolar transformation imposes two algebraic constraints on the camera calibration. If two epipolar transformations, arising from different camera displacements, are available then the compatible camera calibrations are parameterized by an algebraic curve of genus four. The curve can be represented either by a space curve of degree seven contained in the intersection of two cubic surfaces, or by a curve of degree six in the dual of the image plane. The curve in the dual plane has one singular point of order three and three singular points of order two.If three epipolar transformations are available, then two curves of degree six can be obtained in the dual plane such that one of the real intersections of the two yields the correct camera calibration. The two curves have a common singular point of order three.Experimental results are given to demonstrate the feasibility of camera calibration based on the epipolar transformation. The real intersections of the two dual curves are found by locating the zeros of a function defined on the interval [0, 2]. The intersection yielding the correct camera calibration is picked out by referring back to the three epipolar transformations.     

Bandwidth Adaptive Cache Coherence Optimizations for Chip Multiprocessors

Chip Multiprocessors (CMPs) have different technological parameters and physical constraints than earlier multi-processor systems, which should be taken into consideration when designing cache coherence protocols. Also, contemporary cache coherence protocols use invalidate schemes that are known to generate a high number of coherence misses. This is especially true under producer-consumer sharing patterns that can become a performance bottleneck as the number of cores increases. This paper presents two mechanisms to design efficient and scalable cache coherence protocols for CMPs. First, we propose an adaptive hybrid protocol to reduce coherence misses observed in write-invalidate based protocols. The proposed protocol is based on a write-invalidate scheme. However, adaptively, it can push updates to potential consumers based on observed producer-consumer sharing patterns. Secondly, we extend this adaptive protocol with an interconnection resource aware mechanism. Experimental evaluations, conducted on a tiled-CMP via full-system simulation, were used to assess the performance from our proposed dynamic hybrid protocols. Performance analysis is presented on a set of scientific applications from the SPLASH-2 and NAS parallel benchmark suites. Results showed that the proposed mechanisms reduce cache-to-cache sharing misses up to 48 % and speed up application performance up to 34 %. In addition, the proposed interconnection resource aware mechanism is proven to perform well under varying interconnection utilizations.     

Recursive decomposition tree of a Moore co-family and closure algorithm

A collection of sets on a ground set U _n (U _n ?=?{1,2,...,n}) closed under intersection and containing U _n is known as a Moore family. The set of Moore families for a fixed n is in bijection with the set of Moore co-families (union-closed families containing the empty set) denoted ${\mathbb{M}}_n$ . This paper follows the work initiated in Colomb et al. (Ann Math Artif Intell 67(2):109–122, 2013) in which we have given an inductive definition of the lattice of Moore co-families. In the present paper we use this definition to define a recursive decomposition tree of any Moore co-family and we design an original algorithm to compute the closure under union of any family. Then we compare performance of this algorithm to performance of Ganter’s algorithm and Norris’ algorithm.     

Effect of Molybdenum on the Structure and on the Crystallization of SiO2–Na2O–CaO–B2O3 Glasses

Crystallization of the poorly durable Na₂MoO₄ phase able to incorporate radioactive cesium must be avoided in SiO₂–Al₂O₃–B₂O₃–Na₂O–CaO glasses developed for the immobilization of Mo-rich nuclear wastes. Increasing amounts of B₂O₃ and MoO₃ were added to a SiO₂–Na₂O–CaO glass, and crystallization tendency was studied. Na₂MoO₄ crystallization tendency decreased with the increase of B₂O₃ concentration whereas the tendency of CaMoO₄ to crystallize increased due to preferential charge compensation of BO₄⁻ entities by Na⁺ ions. ²⁹Si MAS NMR showed that molybdenum acts as a reticulating agent in glass structure. Trivalent actinides surrogate (Nd³⁺) were shown to enter into CaMoO₄ crystals formed in glasses.     

Inter-MAC Green Path Selection for Heterogeneous Networks

Gigabit home networks represent a key technology to make the Future Internet success a reality. Consumers will require networks to be simple to install, without the need of any new wire and with green consideration. To make this network ubiquitous, seamless and robust, a technology independent MAC layer will ensure its global control and provide connectivities to any number of devices the user wishes to connect to it in any room. In order to make this vision comes true, substantial progress is required in the fields of protocol design and in systems architectures. For this goal, we introduce a new convergence layer denoted inter-MAC, which provides a common infrastructure to the home network, Among the inter-MAC functionalities, we focused the interest on the path selection mechanism including the green aspect. To improve quality of service, reduce energy consumption and radiofrequency devices number, we define a new path selection protocol based on several metrics. We present some preliminary results obtained on an experimental test bed.