Pseudotumoral hyperplasia of Brunner's glands

Hyperplasia of Brünner's glands is a dysembryoplastic or hyperplasic lesion with an elective location of the proximal duodenum. Symptoms are often non-specific but severe manifestations can occur (haemorrhage, duodenal obstruction). Two cases of hyperplasia of Brünner's glands were reported due to their particularly large size and a misguiding clinical appearance. Difficulties in diagnosis due to this rare benign entity were discussed.     

First evidence of natural vertical transmission of yellow fever virus in Aedes aegypti, its epidemic vector

Entomological investigations were conducted in 1995 in Senegal, following a yellow fever (YF) outbreak. A total of 1125 mosquitoes collected in the field, including males, females and 12-48 h old newly emerged adults reared from wild-caught larvae, were tested for YF virus. Among the 22 species captured, Aedes aegypti was the most common. 'Wild' vectors of YF were also captured, including A. furcifer, A. metallicus and A. luteocephalus. In all, 28 YF virus isolations were made: 19 from A. aegypti females, including 2 from newly emerged specimens; 5 were obtained from A. aegypti males, including one from a pool of newly emerged specimens, 2 from A. furcifer females, and one each from a female A. metallicus and a female A. luteocephalus. The true infection rates (TIRs) were much higher in adult A. aegypti than in specimens reared from larvae--8.2% and 31.4% for female and male A. aegypti captured on human volunteers, respectively (P < 0.0001). The TIRs for A. aegypti reared from larvae were 1.4% and 0.5% for females and males, respectively (P > 0.05). This outbreak was an intermediate YF epidemic, involving 4 vector species. Our data provide the first evidence of vertical transmission of YF virus in nature by A. aegypti, its main vector to humans, and strongly suggest that vertical transmission played a major role in the spread of the epidemic.     

Intra-laboratory validation of a concentration method adapted for the enumeration of infectious F-specific RNA coliphage, enterovirus, and hepatitis A virus from inoculated leaves of salad vegetables

Salad vegetables exposed to fecal contamination may cause outbreaks of hepatitis or gastro-enteritis if they are eaten raw. A procedure, based on elution with phosphate-buffered saline and concentration by filtration through membrane filters, was developed for the recovery of enteric viruses from salad leaves. The method was evaluated using lettuce leaves inoculated with hepatitis A virus (HAV), poliovirus, and MS2 bacteriophage. In addition, this method was validated by an intra-laboratory study using leaves of various salad vegetables inoculated with MS2 phage. The French standard NF V 03-110 was used to establish the general principle and the technical protocol of the validation procedure. Linear regression models describing the quantitative reactions were good fits to data in the whole range of viral concentrations tested, which was from about 1 to 4 log plaque-forming units (PFU) per 25 g of lettuce. The fractions of inoculated viruses recovered were estimated to be about 64% for HAV, 18% for poliovirus, and 29% for MS2. No significant effect of the food matrix was found using various types of salad vegetable (butter lettuce, iceberg lettuce, romaine lettuce, witloof chicory, curly endive, corn salad, rocket and watercress). Moreover, the variance of the results was constant for all levels of virus contamination within the experimental range. Intermediate reproducibility experiments were also performed to allow calculation of the uncertainty factor, which was found to be 0.58 log PFU/25 g. When used in association with phage enumeration, this validated procedure is rapid enough to be used for screening salad vegetables for evaluation of the efficacy of processes for control of pathogenic microorganisms on such foods.     

Modeling, Analysis, and Neural Network Control of an EV Electrical Differential

This paper presents system modeling, analysis, and simulation of an electric vehicle (EV) with two independent rear wheel drives. The traction control system is designed to guarantee the EV dynamics and stability when there are no differential gears. Using two in-wheel electric motors makes it possible to have torque and speed control in each wheel. This control level improves EV stability and safety. The proposed traction control system uses the vehicle speed, which is different from wheel speed characterized by a slip in the driving mode, as an input. In this case, a generalized neural network algorithm is proposed to estimate the vehicle speed. The analysis and simulations lead to the conclusion that the proposed system is feasible. Simulation results on a test vehicle propelled by two 37-kW induction motors showed that the proposed control approach operates satisfactorily.     

Model-based approaches for interoperability of next generation enterprise information systems: state of the art and future challenges

Enterprise businesses are more than ever challenged by competitors that frequently refine and tailor their offers to clients. In this context, enterprise information systems (EIS) are especially important because: (1) they remain one of the last levers to increase the performance and competitiveness of the enterprise, (2) we operate in a business world where the product itself has reached a limit of performance and quality due to uniform capacity of industrial tools in a globalized economy and (3) the EIS can increase the product value thanks to additional digital services (built on data associated to the product) in order to meet and fit better client’s needs. However, the use of EISs reaches a limit in collaborative environments because enterprises management methods diverge and EISs are mainly inflexible resource packages that are not built with an interoperability objective. Consequently, we need to make EISs interoperable in order to achieve the needed gains competitiveness and performance. This paper contribution can be summarized as follows: (1) it relates existing work and it examines barriers that, at the moment, are preventing further improvements due to current methodological and technological limits, and (2) it proposes a conceptual framework and five challenges that model based approaches must overcome to achieve interoperability between EIS in the near and long term.     

State of the art review of quality,reliability and maintenance issues in closed-loop supply chains with remanufacturing

The design of reverse logistics and remanufacturing processes and the recovery of end-of-life products have been well-studied in the literature. Quality, reliability, maintenance and warranty for recovered products and the remanufacturing activities that extend their life are integral issues in reverse logistics. This paper reviews recent and relevant literature on these issues in closed-loop supply chains, with a focus on remanufactured or second-hand products. The published literature is first classified into domain areas of research and practice. The wide array of mathematical tools and techniques used in the literature are then identified and mapped. Finally, the findings are summarised and the main research gaps are highlighted.     

Parent-offspring relationships in apomictic guayule

The genetic base of guayule (Parthenium argentatum Gray) germ plasm that is available is narrow; yet, significant variability has been described within this germ plasm. This variability is surprising because guayule reproduces by facultative apomixis (asexual reproduction by seed), but evidence suggests that progress through selection is feasible. It has been hypothesized that this variation has arisen through periodic sexual reproduction; however, this has not been quantified. This study was designed to describe and compare eight components of yield and the expression of two isozyme systems in twenty parent plants and half-sib, open-pollinated families from each parent. Extensive variation for all characters was found among both the parents and the progeny, with fresh and dry weights being highly correlated to rubber yield. Parent-offspring regressions were not significantly different from zero. This implies low heritabilities for the major components of yield in guayule, and we believe that family selection, rather than single-plant selection, may generate higher-yielding and more genetically uniform lines at an escalated rate than single-plant selection. Periodic sexuality resulting in genetic variation was estimated by differences in isozyme expression within the half-sib families. Fifteen of the twenty progeny families were polymorphic for either esterase or peroxidase or both isozymes. This amount of sexuality is significant, and guayule must be considered an open-pollinated crop. We conclude from this study that we should rethink our breeding procedures to include controlled pollination and family selection.     

Dendritic Molecular Nanobatteries and the Contribution of Click Chemistry

This article is a mini-review mostly based on the work of the authors’ laboratory on the redox chemistry of metallodendrimers and gold nanoparticles, with emphasis on “click” chemistry. Late transition-metal sandwich complexes possess a rather unique ability to withstand two or three oxidation states without breakdown, especially with permethylated π-cyclopentadienyl or arene ligands. When they are linked to dendritic cores, the assembled nano-systems undergo chemically and electrochemically reversible transfer of a large number of electrons (up to 14,000). These multiple redox processes are useful for nanodevices behaving as nanobatteries for redox sensing, modified electrode surfaces and redox catalysis. Click chemistry was recently disclosed as one of the most powerful means to form such assemblies including both arene-cored and gold nanoparticle-cored dendrimers.     

Integrated production quality and condition-based maintenance optimisation for a stochastically deteriorating manufacturing system

This paper investigates the problem of optimally integrating production quality and condition-based maintenance in a stochastically deteriorating single- product, single-machine production system. Inspections are periodically performed on the system to assess its actual degradation status. The system is considered to be in ‘fail mode’ whenever its degradation level exceeds a predetermined threshold. The proportion of non-conforming items, those that are produced during the time interval where the degradation is beyond the specification threshold, are replaced either via overtime production or spot market purchases. To optimise preventive maintenance costs and at the same time reduce production of non-conforming items, the degradation of the system must be optimally monitored so that preventive maintenance is carried out at appropriate time intervals. In this paper, an integrated optimisation model is developed to determine the optimal inspection cycle and the degradation threshold level, beyond which preventive maintenance should be carried out, while minimising the sum of inspection and maintenance costs, in addition to the production of non-conforming items and inventory costs. An expression for the total expected cost rate over an infinite time horizon is developed and solution method for the resulting model is discussed. Numerical experiments are provided to illustrate the proposed approach.     

Influence of pressure cycling on damage evolution in an unfilled EPDM exposed to high-pressure hydrogen

This study aims to reveal the internal damage evolution process in a transparent ethylene propylene diene rubber (EPDM) under high-pressure hydrogen cycles (9 and 15 MPa). Damage accumulation of EPDM was tracked from in-situ pictures during cycling. Several dedicated image processing routines allowed the discrimination of mechanisms (separated cavities, clusters and cracks) and sometimes the qualification of their morphology (size distribution, number, ratio of cavities reappearing at any cycle). Numerous small cavities were observed at any cycle, some of them being clustered under the highest pressure. Only part of them systematically appeared again. Some of these cavities inflated and “absorbed” small cavities around them when clustered. Finally, a few cracks were nucleated from some large cavities and grew, following a “stop and grow” process.