CTLA4 mediates antigen-specific apoptosis of human T cells

The regulation of T cell-mediated immune responses requires a balance between amplification and generation of effector function and subsequent selective termination by clonal deletion. Although apoptosis of previously activated T cells can be induced by signaling of the tumor necrosis factor receptor family, these molecules do not appear to regulate T-cell clonal deletion in an antigen-specific fashion. We demonstrate that cross-linking of the inducible T-cell surface molecule CTLA4 can mediate apoptosis of previously activated human T lymphocytes. This function appears to be antigen-restricted, since a concomitant signal T-cell receptor signal is required. Regulation of this pathway may provide a novel therapeutic strategy to delete antigen-specific activated T cells.     

钨带灯的稳定性判据试验

我们通过对国产ＢＷ—１４００型真空钨带灯的稳定性判据进行研究，发现通过钨带灯的电流达到稳定的时间很短（小于５分钟），而钨带灯的灯电阻需要经过２０分钟后才能达到稳定，因此，用电流稳定性作为钨带灯的热平衡判据是不够的，更可靠的判据还应看灯电阻是否达到平衡。     

温度,压力对漂移室气体增益的影响

研究了温度及气体压力对漂移室（工作于正比区）气体放大倍数的影响，温度和气体压力的变化范围分别是５￣４０℃及９０￣１０５ｋＰａ。用实验数据拟合得到了函数关系并测量了几种饱和度下函数中的参数值。     

物联网对图书馆事业的双重影响

作为信息产业的第三次浪潮,物联网技术的发展与应用为人与物、物与物之间的信息交换创造了一个全新的平台。国内物联网技术研究与应用的不断深入,将对图书馆事业的发展产生深远影响。文中探讨了物联网对图书馆事业的双重影响,分析了物联网技术带来的优势和挑战,最后强调了以技术为依托,回归服务本质的理念。     

协议宏功能在PLC串行通信中的应用

越来越多的自动化设备自身配置有串行通信接口（如自动化仪表、变频器、伺服驱动器等）,在工业控制现场与可编程逻辑控制（PLC）之间需要进行大量的数据传输,包括现场数据采集、设备的远程控制等。本文以欧姆龙中型CJ2系列PLC协议宏功能为例,比较以往串行通信功能,在可靠性、程序繁琐程度、调试方便性等几方面的优越性。     

pH传感器温度补偿模型研究

水质pH值在线监测对提高水产品健康养殖至关重要,本文将无线传感器网络与pH值传感器相集成,设计了pH值监测的无线传感器网络系统。为克服pH值测量过程中温度对测量结果的影响,提出了一种pH传感器温度补偿模型,该模型通过pH传感器和PT100铂电阻温度传感器分别测量溶液的pH值和温度,利用最小二乘法对pH值和电压进行线性分析,建立pH传感器的温度补偿模型。实验结果表明,该补偿模型测量精度高,能够实现较精确的pH值在线监测。     

中职学校的计算机上机实验课

通过分析当今社会对中职学校学生的要求和目前中职学校计算机上机实验课中存在的问题,探讨了如何提高中职学校的计算机上机实验课程的教学水平。并根据当前中职学生的状况和特点,结合平时的教学经验,提出一些教学观念。     

洪水预报智能模型在中国半干旱半湿润区的应用对比

为探究不同洪水预报智能模型在我国半干旱半湿润区的应用效果,选用决策树、多层感知器、随机森林和支持向量机4种模型在陕西省3个典型流域进行逐时洪水预报;选择相关系数、纳什效率系数、均方根误差、平均绝对误差和相对误差等评价指标,比较不同预见期下4种模型在半干旱半湿润典型流域洪水预报的适用性。结果表明:在短预见期预报中,4种模型在半湿润区典型流域均可获得较高的预报结果,在半干旱典型流域模拟精度相对偏低,仅支持向量机模型满足预报要求;随着预见期延长,不同模型性能变化差异大,支持向量机模型整体稳定,在小流域实时洪水预报中具有明显优势;随机森林模型与决策树模型精度随预见期延长而缓慢下降,前者适应性更好;多层感知器模型精度随预见期延长而骤减,模型稳定性较差。     

叶片数对超低比转速斜流式水轮机的影响

叶片数是影响超低比转速斜流式水轮机水力性能的因素之一。文章利用Fluent 16.0软件,研究分析了不同叶片数模型在不同流量工况下,外特性曲线以及内部流场分布图。结果表明:不同叶片数时,流量从最高效率点向小流量变化时效率下降的速度要比从最高效率点向大流量变化时的快。对于具体参数组合的超低比转速斜流式水轮机,存在最优的叶片数使得其水力性能最优。     

Maximizing learning without sacrificing the fun: Stealth assessment,adaptivity and learning supports in educational games

In this study, we investigated the validity of a stealth assessment of physics understanding in an educational game, as well as the effectiveness of different game-level delivery methods and various in-game supports on learning. Using a game called Physics Playground, we randomly assigned 263 ninth- to eleventh-grade students into four groups: adaptive, linear, free choice and no-treatment control. Each condition had access to the same in-game learning supports during gameplay. Results showed that: (a) the stealth assessment estimates of physics understanding were valid—significantly correlating with the external physics test scores; (b) there was no significant effect of game-level delivery method on students' learning; and (c) physics animations were the most effective (among eight supports tested) in predicting both learning outcome and in-game performance (e.g. number of game levels solved). We included student enjoyment, gender and ethnicity in our analyses as moderators to further investigate the research questions.