Potential of the Stromal Matricellular Protein Periostin as a Biomarker to Improve Risk Assessment in Prostate Cancer

Prostate cancer (PCa) ranges from indolent to aggressive tumors that may rapidly progress and metastasize. The switch to aggressive PCa is fostered by reactive stroma infiltrating tumor foci. Therefore, reactive stroma-based biomarkers may potentially improve the early detection of aggressive PCa, ameliorating disease classification. Gene expression profiles of PCa reactive fibroblasts highlighted the up-regulation of genes related to stroma deposition, including periostin and sparc. Here, the potential of periostin as a stromal biomarker has been investigated on PCa prostatectomies by immunohistochemistry. Moreover, circulating levels of periostin and sparc have been assessed in a low-risk PCa patient cohort enrolled in active surveillance (AS) by ELISA. We found that periostin is mainly expressed in the peritumoral stroma of prostatectomies, and its stromal expression correlates with PCa grade and aggressive disease features, such as the cribriform growth. Moreover, stromal periostin staining is associated with a shorter biochemical recurrence-free survival of PCa patients. Interestingly, the integration of periostin and sparc circulating levels into a model based on standard clinico-pathological variables improves its performance in predicting disease reclassification of AS patients. In this study, we provide the first evidence that circulating molecular biomarkers of PCa stroma may refine risk assessment and predict the reclassification of AS patients.     

On the evaluation and improvement of Arabic WordNet coverage and usability

Built on the basis of the methods developed for Princeton WordNet and EuroWordNet, Arabic WordNet (AWN) has been an interesting project which combines WordNet structure compliance with Arabic particularities. In this paper, some AWN shortcomings related to coverage and usability are addressed. The use of AWN in question/answering (Q/A) helped us to deeply evaluate the resource from an experience-based perspective. Accordingly, an enrichment of AWN was built by semi-automatically extending its content. Indeed, existing approaches and/or resources developed for other languages were adapted and used for AWN. The experiments conducted in Arabic Q/A have shown an improvement of both AWN coverage as well as usability. Concerning coverage, a great amount of named entities extracted from YAGO were connected with corresponding AWN synsets. Also, a significant number of new verbs and nouns (including Broken Plural forms) were added. In terms of usability, thanks to the use of AWN, the performance for the AWN-based Q/A application registered an overall improvement with respect to the following three measures: accuracy (+9.27 % improvement), mean reciprocal rank (+3.6 improvement) and number of answered questions (+12.79 % improvement).     

An Integrated CAD Methodology for Yield Enhancement of VLSI CMOS Circuits Including Statistical Device Variations

In this paper a novel CAD methodology for yield enhancement of VLSI CMOS circuits including random device variations is presented. The methodology is based on a preliminary characterization of the technological process by means of specific test chips for accurate mismatch modeling. To this purpose, a very accurate position-dependent parameter mismatch model has been formulated and extracted. Finally a CAD tool implementing this model has been developed. The tool is fully integrated in an environment of existing commercial tools and it has been experimented in the STMicroelectronics Flash Memory CAD Group.As an example of application, a bandgap reference circuit has been considered and the results obtained from simulations have been compared with experimental data. Furthermore, the methodology has been applied to the read path of a complex Flash Memory produced by STMicroelectronics, consisting of about 16,000 MOSFETs. Measurements of electrical performances have confirmed the validity of the methodology, and the accuracy of both the mismatch model and the simulation flow.     

On the intersubject generalization ability in extracting kinematic information from afferent nervous signals

In the recent past, many efforts have been carried out in order to evaluate the feasibility of implementing closed-loop controlled neuroprostheses based on the processing of sensory electroneurographic (ENG) signals. The success of these techniques mostly relies on the development of processing algorithms capable of extracting the necessary kinematic information from these signals. Soft-computing algorithms can be very useful when dealing with the complexity of the neuromuscular system because of their generalization ability and model-free structure. In this paper, these techniques were used to extract angular position information from the ENG signals recorded from muscle afferents in animal model using cuff electrodes. Specifically, a genetic algorithm-based dynamic nonsingleton fuzzy logic system (named GA-DNSFLS) was developed and tested on different types of angular trajectories (characterized by small or large angular excursions). In particular, two different Takagi-Sugeno-Kang (TSK)-like structures were used in the consequent part of the neuro-fuzzy model in order to verify which one could improve the generalization abilities (intrasubject and intersubject). The results showed that the GA-DNSFLS was able to reconstruct the trajectories giving interesting results in terms of correlation between the actual and the predicted trajectories for small excursion movements during intrasubject and intersubject tests. Particularly, one of the TSK models showed better results in terms of intersubject generalization. The simulations conducted with the large excursion movements led in some cases to interesting results but further experiments are necessary in order to analyze this point more in deep.     

TCP Performance in Optical Packet-switched Networks

Optical packet assembly is a key function to support inter-working between TCP/IP networks and optical packet-switched networks. It is characterized by the assembly delay and by the segment aggregation needed to form an optical packet. These counter-balancing aspects depend on several environment variables, such as the TCP parameters, the access link speed, the optical packet size whose effects are studied in this paper. Performance evaluations are obtained by extensive simulations in terms of send rate of TCP flows, fairness, efficiency, and assembly delay. Some guidelines in the design of optical packets that take into account the results presented are given.     

Provably-Secure Time-Bound Hierarchical Key Assignment Schemes

A time-bound hierarchical key assignment scheme is a method to assign time-dependent encryption keys to a set of classes in a partially ordered hierarchy, in such a way that each class can compute the keys of all classes lower down in the hierarchy, according to temporal constraints.     

A new method for the analysis of integrated transmission lines

A flexible and efficient technique for the analysis of transmission lines is described. The transmission line is considered as the union of « elementary waveguides », where the medium is uniformly stratified. The modes are determined by matching the field at the interfaces using a procedure that leads to a linear eigenvalue problem involving a limited number of variables.     

Reverberating chambers as sources of stochastic electromagneticfields

Reverberating chambers are of recognized relevance in many EMC applications since they allow us to generate a reference electromagnetic statistical field. This paper investigates the electromagnetic field in reverberating chambers. Reverberating chambers are large overmoded cavities wherein a nonstationary electromagnetic field is present. This electromagnetic field is stochastic in nature; therefore, proper analytical tools need to be considered in order to characterize it. We deal with the theoretical aspects related to the characterization of the electromagnetic field inside the chamber and with the application to the case of the reverberating chamber of the Istituto Universitario Navale     

Bioinspired Security Analysis of Wireless Protocols

Fraglets represent an execution model for communication protocols that resembles the chemical reactions in living organisms. The strong connection between their way of transforming and reacting and formal rewriting systems makes a fraglet program amenable to automatic verification. Grounded on past work, this paper investigates feasibility of adopting fraglets as model for specifying security protocols and analysing their properties. In particular, we give concrete sample analyses over a secure RFID protocol, showing evolution of the protocol run as chemical dynamics and simulating an adversary trying to circumvent the intended steps. The results of our analysis confirm the effectiveness of the cryptofraglets framework for the model and analysis of security properties and eventually show its potential to identify and uncover protocol flaws.     

Toward automatic phenotyping of developing embryos from videos.

We describe a trainable system for analyzing videos of developing C. elegans embryos. The system automatically detects, segments, and locates cells and nuclei in microscopic images. The system was designed as the central component of a fully automated phenotyping system. The system contains three modules 1) a convolutional network trained to classify each pixel into five categories: cell wall, cytoplasm, nucleus membrane, nucleus, outside medium; 2) an energy-based model, which cleans up the output of the convolutional network by learning local consistency constraints that must be satisfied by label images; 3) a set of elastic models of the embryo at various stages of development that are matched to the label images.