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51.
52.
Laurent Bédouet Florentina Pascale Michel Bonneau Alexandre Laurent 《Drug development and industrial pharmacy》2015,41(1):85-94
Intra-articular drug delivery systems (DDSs) are envisaged as interesting alternative to locally release non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen to reduce pain in patients with osteoarthritis. The present study examines the efficacy of S-(+)-ibuprofen on cartilage degradation as drug candidate for DDS loading. Humeral cartilage and joint capsule explants were collected from healthy sheep shoulder joints and they were cultured in mono- or in co-culture for 13?days with LPS in combination with S-(+)-ibuprofen at 50?µM and 1?mM. S-(+)-ibuprofen (50?µM) blocked prostaglandins production in LPS-activated explants but did not reduce cartilage degradation. By contrast, 1?mM S-(+)-ibuprofen treatment of cartilage explants reduced nitric oxide synthesis by 51% (p?=?0.0072), proteoglycans degradation by 35% (p?=?0.0114) and expression of serum amyloid protein – the main protein induced upon LPS challenge – by 44% (p?0.0001). On contrary, in presence of synovial membrane, the protective effects of S-(+)-ibuprofen on cartilage damages were significantly diminished. At 1mM, S-(+)-ibuprofen reduced the cell lysis during culture of cartilage and joint capsule either in mono- or in co-culture. This study performed on sheep explants shows that 1?mM S-(+)-ibuprofen inhibited cartilage degradation via a mechanism independent of cyclooxygenase inhibition. Reduction of prostaglandins synthesis at 50?µM in all treatment groups and reduction of cartilage degradation observed at 1?mM suggest that S-(+)-ibuprofen could be considered as a promising drug candidate for the loading of intra-articular DDS. 相似文献
53.
Klesges Robert C.; Somes Grant; Pascale Randy W.; Klesges Lisa M.; Murphy Michael; Brown Kendra; Williams Ellen 《Canadian Metallurgical Quarterly》1988,7(5):387
198 men and 413 women responded to random telephone surveys in Fargo, North Dakota and Memphis, Tennessee. Each S was given the Smoking Attitudes Survey, which assesses generalized health beliefs and health-related problems associated with smoking. Ss' knowledge of smoking-associated diseases and diseases not associated with smoking was also assessed. Stepwise regression analysis of composite knowledge scores revealed 4 predictors of the health consequences of smoking: education, race, smoking status, and income. Smokers reported less knowledge and less concern about health consequences of smoking, were more likely to be male, and were more concerned about health consequences of cholesterol. The best predictor of smokers who had never attempted cessation was their greater concern over weight control, compared with smokers with a history of smoking-cessation attempts. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
54.
Freret Thomas; Chazalviel Laurent; Roussel Simon; Bernaudin Myriam; Schumann-Bard Pascale; Boulouard Michel 《Canadian Metallurgical Quarterly》2006,120(6):1285
The assessment of both histological and functional long-term outcomes after cerebral ischemia is increasingly recommended for preclinical studies. Whereas correlations between behavioral impairments and primary ischemic lesion are documented, little is known about their relationships with remote nonischemic regions that undergo secondary degeneration, such as the thalamus. Anesthetized rats were subjected to mild (30 min) or severe (60 min) occlusion of the middle cerebral artery. Two months after ischemia, sensorimotor behavior was assessed according to the neurological score, limb-placing, adhesive-removal, and staircase tests; the final histological lesion was measured after this assessment. Cortical damage was correlated to all transient and long-lasting sensorimotor deficits, whereas striatal lesion was more consistently reflected by the forelimb-placing reflexes and adhesive-removal motor deficits. By contrast, the thalamic atrophy was not correlated to early neurological impairment, but rather to the late sensory deficit at the adhesive-removal test and to the skilled forepaw reaching alteration at the staircase test. This suggests that thalamus contributes, albeit moderately, to the ischemia-induced long-lasting sensorimotor deficits, some of which represent relevant targets for therapeutic interventions. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
55.
Take care! The evaluation of a team-based burnout intervention program for oncology care providers. 总被引:1,自引:0,他引:1
Le Blanc Pascale M.; Hox Joop J.; Schaufeli Wilmar B.; Taris Toon W.; Peeters Maria C. W. 《Canadian Metallurgical Quarterly》2007,92(1):213
In this quasi-experimental study among staff of 29 oncology wards, the authors evaluated the effects of a team-based burnout intervention program combining a staff support group with a participatory action research approach. Nine wards were randomly selected to participate in the program. Before the program started (Time 1), directly after the program ended (Time 2), and 6 months later (Time 3), study participants filled out a questionnaire on their work situation and well-being. Results of multilevel analyses showed that staff in the experimental wards experienced significantly less emotional exhaustion at both Time 2 and Time 3 and less depersonalization at Time 2, compared with the control wards. Moreover, changes in burnout levels were significantly related to changes in the perception of job characteristics over time. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
56.
A. Ritacco R. Adam A. Adane P. Ade P. André A. Beelen B. Belier A. Benoît A. Bideaud N. Billot O. Bourrion M. Calvo A. Catalano G. Coiffard B. Comis A. D’Addabbo F.-X. Désert S. Doyle J. Goupy C. Kramer S. Leclercq J. F. Macías-Pérez J. Martino P. Mauskopf A. Maury F. Mayet A. Monfardini F. Pajot E. Pascale L. Perotto G. Pisano N. Ponthieu M. Rebolo-Iglesias V. Revéret L. Rodriguez G. Savini K. Schuster A. Sievers C. Thum S. Triqueneaux C. Tucker R. Zylka 《Journal of Low Temperature Physics》2016,184(3-4):724-732
57.
58.
Pascale Satgé de Caro Zéphirin Mouloungui Antoine Gaset 《Journal of the American Oil Chemists' Society》1997,74(3):235-240
Alkyl glycidyl ethers and bis glycidyl ethers, synthesized in a heterogeneous weakly hydrous medium, were condensed with primary
or secondary amines to obtain 3-alkyloxy propanolamines or bis alkyloxy propanolamines in a regioselective manner. The compounds
were characterized by conventional spectroscopic methods, and complete nuclear magnetic resonance data are given. Their high-temperature
stability, their good emulsifying power, their oxidation, and corrosion inhibition make these compounds suitable for solubilizing
ethanol-diesel fuel blends. 相似文献
59.
Vertically aligned carbon nanotube‐based composite: Elaboration and monitoring of the nanotubes alignment
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Mickael Huard Florent Roussel Stéphan Rouzière Stéphanie Patel Mathieu Pinault Martine Mayne‐L'Hermite Pascale Launois 《应用聚合物科学杂志》2014,131(1)
We present the different elaboration steps of a composite formed of carbon nanotubes (CNT) carpet embedded in an epoxy polymer. Detailed characterization at each step of the elaboration process is performed. The good alignment of CNT in as‐grown carpets is kept all along the elaboration process of the composite, as it is measured at both macro and microscopic scales by X‐ray scattering. We also ensured by X‐ray fluorescence measurements that the iron‐based catalyst particles used for the synthesis were removed from the carpet after a high temperature post‐annealing treatment. These measurements give valuable information for further applications involving unidirectional nanotube composites and membranes, where CNT alignment is a key parameter. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 39730. 相似文献
60.
Isabelle L. Di Ma?o Pascale Barbier Diane Allegro Cédric Brault Vincent Peyrot 《International journal of molecular sciences》2014,15(8):14697-14714
The interaction between the microtubule associated protein, tau and the microtubules is investigated. A fluorescence resonance energy transfer (FRET) assay was used to determine the distance separating tau to the microtubule wall, as well as the binding parameters of the interaction. By using microtubules stabilized with Flutax-2 as donor and tau labeled with rhodamine as acceptor, a donor-to-acceptor distance of 54 ± 1 Å was found. A molecular model is proposed in which Flutax-2 is directly accessible to tau-rhodamine molecules for energy transfer. By titration, we calculated the stoichiometric dissociation constant to be equal to 1.0 ± 0.5 µM. The influence of the C-terminal tails of αβ-tubulin on the tau-microtubule interaction is presented once a procedure to form homogeneous solution of cleaved tubulin has been determined. The results indicate that the C-terminal tails of α- and β-tubulin by electrostatic effects and of recruitment seem to be involved in the binding mechanism of tau. 相似文献