Hodgkin's disease: impact on childbearing

Although Hodgkin's disease is considered one of the "curable" cancers, the high cure rates associated with this disease are not accomplished without risk of potentially severe, immediate, and late side effects. Because the predominant histologic subtype of Hodgkin's disease found in the United States generally affects the 15- to 25-year-old age group, the disease, its treatment, and the side effects of treatment will affect many women of childbearing age. The treatment and its effects on the patient and offspring, including posttreatment fertility, are key issues for perinatal nurses.     

Correlation between lymphocyte-induced donor-specific tolerance and donor cell recirculation. Role of class I and class II major histocompatibility complex

Intravenous infusion of mice with viable allogeneic lymphocytes can produce donor-specific enhancement of skin graft survival, but only if the injected lymphocytes can persist in the host's recirculating lymphocyte pool for at least 3 days. We have investigated the relative roles of class I and class II MHC for C57BL/6 mice infused with lymphoid cells from co-isogenic strains mutated at class I MHC (bm1) or class II MHC (bm12), and for A.TH lymphoid cells infused into C3H (class I different, class II identical) or A.TH (class II different, class I identical). Injected cells differing from the host at class I MHC, but not at class II MHC, can be rapidly removed by host natural immune mechanisms (probably NK cells). Persistence is favored if the injected cells also carry host class I MHC, i.e., tolerance is more readily induced by injecting F1 (A x B) into A rather than B into A, consistent with the "missing self" hypothesis of NK recognition, with class I MHC being the relevant self-marker. Injected cells differing from the host at class II MHC but not at class I MHC always persist for at least 3 days, even when class I-different cells are being actively removed.     

Honey bees find the shortest path: a collective flow-mediated approach

Artificial Life and Robotics - Honey bees (Apis mellifera L.) are social insects that makes frequent use of volatile pheromone signals to collectively navigate unpredictable and unknown...     

High Q 2D-length extension mode resonators for potential time–frequency applications

Microsystem Technologies - This paper presents recent advances on two dimensional length-extension mode (2D-LEM) quartz resonators providing high quality (Q) factor on resonances at a few MHz. The...     

Design of synthetic materials for intracellular delivery of RNAs: From siRNA-mediated gene silencing to CRISPR/Cas gene editing

Ribonucleic acids (RNAs) possess great therapeutic potential and can be used to treat a variety of diseases. The unique biophysical properties of RNAs, such as high molecular weight, negative charge, hydrophilicity, low stability, and potential immunogenicity, require chemical modification and development of carriers to enable intracellular delivery of RNAs for clinical use. A variety of nanomaterials have been developed for the effective in vivo delivery of short/ small RNAs, messenger RNAs, and RNAs required for gene editing technologies including clustered regularly interspaced palindromic repeat (CRISPR)/Cas. This review outlines the challenges of delivering RNA therapeutics, explores the chemical synthesis of RNA modifications and carriers, and describes the efforts to design nanomaterials that can be used for a variety of clinical indications.     

A nonlinear geometric approach to power system excitation control and stabilization

In this paper, a unified approach to the design of a nonlinear excitation controller/power system stabilizer for a synchronous generator/infinite bus power system is presented. The approach is based on a form of state feedback linearization, known as input–output feedback linearization, which provides an exact semi-global state transformation that is valid for a large class of operating points of the power system. With this transformation, the terminal voltage becomes a linear function of the control input. The excitation controller/power system stabilizer is then synthesized by using linear controller design techniques. The controller is proven to provide small signal stability and to provide local asymptotic tracking of admissible constant reference signals for a large class of operating points. A procedure is given to tune the controller gains to provide significant damping of the power angle oscillations.     

The first measurement of an absolute surface concentration of reaction intermediates in ethylene hydrogenation

The first measurement of a turnover rate with respect to surface intermediate concentration in a high pressure heterogeneous catalytic reaction is reported. By using infrared-visible sum frequency generation to study the hydrogenation of ethylene on Pt(111), it was found that the surface concentration of -bonded ethylene, the key reaction intermediate, represented approximately 4% of a monolayer. Thus the absolute turnover rate per surface adsorbed ethylene molecule is 25 times faster than the rate measured per platinum atom. To explain these results, we propose a model of weakly adsorbed ethylene intermediates reacting on atop sites.     

Spin correlations for an Anderson impurity in conventional and unconventional superconductors

We present a theoretical study of the spin-spin correlation functionC(r) in a superconductor, whereC(r) = S · s(r);S is an impurity spin operator, ands(r) is the conduction electron spin density operator. We model the impurity using the Anderson Hamiltonian, and use the U , 1/N expansion to do the calculations. In addition to conventional superconductors, we consider unconventional superconductors, in which the order parameter (k) has a lower rotational symmetry, and has vanishing angular average. Of particular interest is the way that the behavior ofC(r) reflects two length scales, the Kondo length _k and the superconducting coherence length, ₀, and the way that its behavior is affected by the angular dependence of unconventional gaps.     

Iterant recombination with one-norm minimization for multilevel Markov chain algorithms via the ellipsoid method

Recently, it was shown how the convergence of a class of multigrid methods for computing the stationary distribution of sparse, irreducible Markov chains can be accelerated by the addition of an outer iteration based on iterant recombination. The acceleration was performed by selecting a linear combination of previous fine-level iterates with probability constraints to minimize the two-norm of the residual using a quadratic programming method. In this paper we investigate the alternative of minimizing the one-norm of the residual. This gives rise to a nonlinear convex program which must be solved at each acceleration step. To solve this minimization problem we propose to use a deep-cuts ellipsoid method for nonlinear convex programs. The main purpose of this paper is to investigate whether an iterant recombination approach can be obtained in this way that is competitive in terms of execution time and robustness. We derive formulas for subgradients of the one-norm objective function and the constraint functions, and show how an initial ellipsoid can be constructed that is guaranteed to contain the exact solution and give conditions for its existence. We also investigate using the ellipsoid method to minimize the two-norm. Numerical tests show that the one-norm and two-norm acceleration procedures yield a similar reduction in the number of multigrid cycles. The tests also indicate that one-norm ellipsoid acceleration is competitive with two-norm quadratic programming acceleration in terms of running time with improved robustness.