可持续理念的体现——杭州来福士中心

正UNStudio由Ben van Berkel和Caroline Bos创立,是一个国际性的建筑设计网络。拥有三个全方位服务的国际事务所,分别位于阿姆斯特丹、香港和上海。专于建筑、室内建筑、产品设计、城市发展和基础设施项目。地址:浙江省杭州市钱江新城富春路业主方:凯德集团建筑面积:392526m~2项目年份:2017醒目的裙楼之上坐落着两座流线型的高楼,从中可以饱览钱塘江和西湖的迷人风光。     

V-FPGAs: Increasing Performance with Manual Placement,Timing Extraction and Extended Timing Modeling

Journal of Signal Processing Systems - Virtual FPGAs (V-FPGAs) are used as vendor-independent virtualization layers, to retrofit features which are not available on the host FPGA and to prototype...     

Naevi spili, Café-au-lait spots and melanocytic naevi aggregated alongside Blaschko''s lines, with a review of segmental melanocytic lesions

Lipofibromatous hamartoma of the nerve is a very uncommon congenital tumor. An association between this condition and vascular malformations is not well known. We present an 11-year-old girl with a lipofibromatous hamartoma of the right median nerve with macrodactyly. She had small red macules on her right neck, chest, and arm, which were diagnosed clinically as port-wine stains. The specimens of the enlarged nerves showed fibrous and fatty growth surrounding the nerve bundles and proliferation of the small veins. We suggest that this disorder can be accompanied by a vascular malformation.     

国际投资广场

国际投资广场是北京的一个新区域，它为现代商住混合的城市提供了一个高效而可持续发展的场所。 场地位于五六环之间的亦庄经济技术开发区的核心地带。在UNStudio的总体规划中，国际投资广场的布局带有一些对中国传统生活方式的隐喻，同时也表达了保持独立性与邻里在社交相平衡的当代生活观念。     

杭州RAFFLES城

杭州Raffles城发展坐落于浙江省省会杭州市的钱塘江边，是嘉德置地继新加坡、上海、北京、成都和巴林之后的第六栋，将零售店、办公楼、住户和酒店设施融于一体，成为新城区的文化地标。     

Atom lithography using light forces

Atom lithography provides a new technology that enables one to write directly nanometer scale structures onto a substrate in a parallel process. With this technique the trajectories of atoms are manipulated by light forces that efficiently focus the atoms in a standing light field produced by a laser. By chosing different standing light field configurations one can write different periodic patterns. Theoretical calculations predict a linewidth of the deposited structures in the range of 10–20 nm. The technique is a parallel, direct and species selective process involving low particle energy that prevents any damage of the substrate.     

The Neonatal Fc Receptor Is Elevated in Monocyte-Derived Immune Cells in Pancreatic Cancer

The neonatal Fc receptor (FcRn) is responsible for recycling of IgG antibodies and albumin throughout the body. This mechanism has been exploited for pharmaceutic delivery across an array of diseases to either enhance or diminish this function. Monoclonal antibodies and albumin-bound nanoparticles are examples of FcRn-dependent anti-cancer therapeutics. Despite its importance in drug delivery, little is known about FcRn expression in circulating immune cells. Through time-of-flight mass cytometry (CyTOF) we were able to characterize FcRn expression in peripheral blood mononuclear cell (PBMC) populations of pancreatic ductal adenocarcinoma (PDAC) patients and non-cancer donors. Furthermore, we were able to replicate these findings in an orthotopic murine model of PDAC. Altogether, we found that in both patients and mice with PDAC, FcRn was elevated in migratory and resident classical dendritic cell type 2 (cDC2) as well as monocytic and granulocytic myeloid-derived suppressor cell (MDSC) populations compared to tumor-free controls. Furthermore, PBMCs from PDAC patients had elevated monocyte, dendritic cells and MDSCs relative to non-cancer donor PBMCs. Future investigations into FcRn activity may further elucidate possible mechanisms of poor efficacy of antibody immunotherapies in patients with PDAC.     

Evaluation of permeation of organic solvents through PVC,asbestos/cement,and ductile iron pipes

Buried potable waterpipes are susceptible to permeation by organic solvents. In studying piping made of PVC, asbestos/cement, and ductile iron, full-pipe assemblies and laboratory bench techniques were employed. Elastomeric gaskets for all three systems become permeated, at least under exaggerated conditions. Results show that thermodynamic activity, as opposed to concentration, is the driving force. At solvent activities well above those encountered in typical soil, PVC is seen to be an effective barrier against permeation.