Multicriteria decisions on interdependent infrastructure transportation projects using an evolutionary-based framework

When evaluating transportation infrastructure projects and determining which of them will be carried out from a set of projects and given a budget constraint, several criteria need to be considered in the decision. Standard evaluation practices imply the aggregation of impacts into one utility function which is later optimized. Nevertheless these techniques used for translation of different measuring units into monetary terms are highly controversial. Multicriteria techniques can explicitly deal with different measuring units, however, they are not suitable to model interdependence relationships of projects that share a common characteristic (same route, location or target population, for instance). In this research we model this transportation planning problem, the multi-objective transportation infrastructure project selection problem (MTIPSP), as a constrained multi-objective optimization problem with quadratic objective functions, using a variation of the multi-objective 0–1 knapsack problem plus some additional constraints. Given the combinatorial nature of the problem, an evolutionary-based framework is used for the identification of Pareto solutions, and later, those with non-attractive properties are filtered using a Knee Identification Procedure. The final selection of the projects portfolio is made using a well known multicriteria decision aid method and including the decision makers’ preferences based on the existing context.     

Efficient simulation of tissue-like P systems by transition cell-like P systems

In the framework of P systems, it is known that the construction of exponential number of objects in polynomial time is not enough to efficiently solve NP-complete problems. Nonetheless, it could be sufficient to create an exponential number of membranes in polynomial time. Working with P systems whose membrane structure does not increase in size, it is known that it is not possible to solve computationally hard problems (unless P = NP), basically due to the impossibility of constructing exponential number of membranes, in polynomial time, using only evolution, communication and dissolution rules. In this paper we show how a family of recognizer tissue P systems with symport/antiport rules which solves a decision problem can be efficiently simulated by a family of basic recognizer P systems solving the same problem. This simulation allows us to transfer the result about the limitations in computational power, from the model of basic cell-like P systems to this kind of tissue-like P systems.     

Multimodal focus attention and stress detection and feedback in an augmented driver simulator

This paper presents a driver simulator, which takes into account the information about the user’s state of mind (level of attention, fatigue state, stress state). The user’s state of mind analysis is based on video data and biological signals. Facial movements such as eyes blinking, yawning, head rotations, etc., are detected on video data: they are used in order to evaluate the fatigue and the attention level of the driver. The user’s electrocardiogram and galvanic skin response are recorded and analyzed in order to evaluate the stress level of the driver. A driver simulator software is modified so that the system is able to appropriately react to these critical situations of fatigue and stress: some audio and visual messages are sent to the driver, wheel vibrations are generated and the driver is supposed to react to the alert messages. A multi-threaded system is proposed to support multi-messages sent by the different modalities. Strategies for data fusion and fission are also provided. Some of these components are integrated within the first prototype of OpenInterface: the multimodal similar platform.     

Generating relational database transactions from eb 3 attribute definitions

eb ³ is a trace-based formal language created for the specification of information systems. In eb ³, each entity and association attribute is independently defined by a recursive function on the valid traces of external events. This paper describes an algorithm that generates, for each external event, a transaction that updates the value of affected attributes in their relational database representation. The benefits are twofold: eb ³ attribute specifications are automatically translated into executable programs, eliminating system design and implementation steps; the construction of information systems is streamlined, because eb ³ specifications are simpler and shorter to write than corresponding traditional specifications, design and implementations. In particular, the paper shows that simple eb ³ constructs can replace complex SQL queries which are typically difficult to write.

Proteomic Helicobacter pylori biomarkers discriminative of low-grade gastric MALT lymphoma and duodenal ulcer

To date no reliable diagnostic method exists to predict, among the very large and clinically heterogeneous group of Helicobacter pylori‐infected patients, the extremely small group at risk for developing low‐grade gastric MALT lymphoma (LG‐MALT). Search of proteomic biomarkers holds promise for the classification of the H. pylori strains with regard to this severe clinical outcome. In the present study 69 H. pylori strains isolated from patients with two different H. pylori‐associated diseases, duodenal ulcer (DU, n=29) and LG‐MALT (n=40) were used. Protein expression patterns of the strains were analyzed by using the high‐throughput methodology SELDI. Selected proteins were purified by means of chromatographic and electrophoretic methods in view of further sequencing by LC‐MS/MS. Univariate analysis (Mann–Whitney test) of the protein expression patterns generated nine significant biomarkers that can discriminate between H. pylori strains from patients with DU and LG‐MALT. These biomarkers are of low molecular weight, ranging from 6 to 26.6 kDa. Among them, two are overexpressed in LG‐MALT strains and seven – in DU strains. Two biomarker proteins, one overexpressed in LG‐MALT strains (13.2 kDa) and another one – overexpressed in DU strains (26.6 kDa), were purified to homogeneity and identified by using LC‐MS/MS as a 50S ribosomal protein L7/L12 and a urease subunit, respectively. These biomarkers can be included in novel protein arrays for the differential diagnosis of H. pylori‐associated clinical outcomes.     

Wide band resonant ultrasound spectroscopy of spheroidal modes for high accuracy estimation of Poisson coefficient of balls

An original inversion method specifically adapted to the estimation of Poisson coefficient of balls by using their resonance spectra is described. From the study of their elastic vibrations, it is possible to accurately characterize the balls. The proposed methodology can create both spheroidal modes in the balls and detect such vibrations over a large frequency range. Experimentally, by using both an ultrasonic probe for the emission (piezoelectric transducer) and a heterodyne optic probe for the reception (interferometer), it was possible to take spectroscopic measurements of spheroidal vibrations over a large frequency range (100 kHz-45 MHz) in a continuous regime. This method, which uses ratios between wave resonance frequencies, allows the Poisson coefficient to be determined independently of Young's modulus and the ball's radius and density. This has the advantage of providing highly accurate estimations of Poisson coefficient (+/-4.3 x 10(-4)) over a wide frequency range.     

On the interpretation of the forbidden spots observed in the electron diffraction patterns of flat Au triangular nanoparticles

In many cases nanostructures present forbidden spots in their electron diffraction patterns when they are observed by transmission electron microscopy (TEM). To interpret their TEM and high resolution transmission electron microscopy (HRTEM) images properly, an understanding of the origin of these spots is necessary. In this work we comment on the origin of the forbidden spots observed in the [111] and [112] electron diffraction patterns of flat gold triangular nanoparticles. The forbidden spots were successfully indexed as corresponding to the first laue Zone (FOLZ) and the HRTEM images presented a contrast produced by the interference of the zero-order Laue zone (ZOLZ) and FOLZ spots. We discuss the use of the forbidden spots in the study of the structure of nanoparticles and show that they are related to the shape and incompleteness of layers in the very thin particles.     

Slips and falls in a cold climate: underfoot surface, footwear design and worker preferences for preventive measures

Slips and falls and associated outdoor injuries are prevalent in cold climates. The objectives of this field investigation were to describe the consequences of slips and falls on ice and snow and the associated injuries, to assess the risks of various icy and snowy surfaces, to identify design needs of footwear, and to ascertain preventive measure preferences of outdoor workers. The organizations investigated were a newspaper delivery service, a military regiment, mining and construction industries. The results showed that fall events occur most frequently on ice covered with snow. This is due to the difficulty of perceiving hidden risks in order to adjust gait strategies. The professional footwear provided does not provide enough protection against slips and falls. Slip resistant properties are ranked as one of the top requirements by the users. Their most preferred preventive measures are footwear with anti-slip properties and the application of anti-slip materials, such as sand or salt.     

Weight distribution and dual distance

Several results in coding theory (e.g. the Carlitz-Uchiyama bound) show that the weight distributions of certain algebraic codes of lengthn are concentrated aroundn/2 within a range of width n. It is proved in this article that the extreme weights of a linear binary code of sufficiently high dual distance cannot be too close ton/2, the gap being of order n. The tools used involve the Pless identities and the orthogonality properties of Krawtchouk polynomials, as well as estimates on their zeroes. As a by-product upper bounds on the minimum distance of self-dual binary codes are derived.     

Mammalian class IV alcohol dehydrogenase (stomach alcohol dehydrogenase): structure, origin, and correlation with enzymology

The structure of a mammalian class IV alcohol dehydrogenase has been determined by peptide analysis of the protein isolated from rat stomach. The structure indicates that the enzyme constitutes a separate alcohol dehydrogenase class, in agreement with the distinct enzymatic properties; the class IV enzyme is somewhat closer to class I (the "classical" liver alcohol dehydrogenase; approximately 68% residue identities) than to the other classes (II, III, and V; approximately 60% residue identities), suggesting that class IV might have originated through duplication of an early vertebrate class I gene. The activity of the class IV protein toward ethanol is even higher than that of the classical liver enzyme. Both Km and kcat values are high, the latter being the highest of any class characterized so far. Structurally, these properties are correlated with replacements at the active site, affecting both substrate and coenzyme binding. In particular, Ala-294 (instead of valine) results in increased space in the middle section of the substrate cleft, Gly-47 (instead of a basic residue) results in decreased charge interactions with the coenzyme pyrophosphate, and Tyr-363 (instead of a basic residue) may also affect coenzyme binding. In combination, these exchanges are compatible with a promotion of the off dissociation and an increased turnover rate. In contrast, residues at the inner part of the substrate cleft are bulky, accounting for low activity toward secondary alcohols and cyclohexanol. Exchanges at positions 259-261 involve minor shifts in glycine residues at a reverse turn in the coenzyme-binding fold. Clearly, class IV is distinct in structure, ethanol turnover, stomach expression, and possible emergence from class I.