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31.
随着集成电路技术的发展及计算机性能的不断提高,计算机组装结构设计在计算机,总体设计中的地位越来越重要,它直接影响到计算机性能的提高。本文针对一个基于工作站和EUCLID-IS软件的电子计算机组结构CAD系统,从软、硬件平台,系统功能及实现等方面进行了讨论,旨在为电子计算机组装结构设计提供一种强有力的、方便的设计工具,有利于增强国产计算机的市场竞争能力。 相似文献
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Production by N-nitroso compounds of O6-alkylguanine (O6-alkylG) in DNA directs the misincorporation of thymine during DNA replication, leading to G:C to A:T transition mutations, despite the fact that DNA containing O6-alkylG:T base pairs is less stable than that containing O6-alkylG:C pairs. We have examined the kinetics of incorporation by Klenow fragment (KF) of Escherichia coli DNA polymerase I of thymine (T) and of cytosine (C) opposite O6-MeG in the template DNA strand. Both T and C were incorporated opposite O6-MeG much slower than nucleotides forming regular A:T or G:C base pairs. Using various concentrations of dTTP, dCTP, or their phosphorothioate (Sp)-dNTP alpha S analogues, or a mixture of dTTP and dCTP, the progress of incorporation of a single nucleotide in a single catalytic cycle of a preformed KF-DNA complex was measured (pre-steady-state kinetics). The results were consistent with the kinetic scheme (Kuchta, R. D., Benkovic, P., & Benkovic, S. J. (1988) Biochemistry 27, 6716-6725): (1) binding of dNTP to polymerase-DNA; (2) conformational change in polymerase; (3) formation of phosphodiester between the dNTP and the 3'-OH of the primer; (4) conformational change of polymerase; (5) release of pyrophosphate. The results were analyzed mathematically to identify the steps at which the rate constants differ significantly between the incorporation of T and C. The only significant difference was the 5-fold difference in the rates of formation of the phosphodiester bond (for dTTP, kforward = 3.9 s-1 and kback = 1.9 s-1; for dCTP, kforward = 0.7 s-1 and kback = 0.9 s-1). These pre-steady-state progress curves were biphasic with a rapid initial burst followed by an apparently steady-state rise. Deconvolution of these curves gave direct evidence for the importance of the conformational change after polymerization by showing that the curves represented the sum of the rapid accumulation of the product of step 3 followed by the slow conversion of that to the product of step 5 (because of the rapidity of the release of pyrophosphate there was no significant accumulation of the product of step 4). The equilibrium constants for each step suggest that the greatest change in the Gibbs free energy occurs at the conformational change after polymerization and that while the formation of the phosphodiester bond to T is slightly exothermic, that to C is slightly endothermic.(ABSTRACT TRUNCATED AT 400 WORDS) 相似文献
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本文对采用区内C/I平衡的多区蜂窝CDMA系统下行链路的性能进行分析,给出两种区内C/I平衡算法并比较它们的性能,考虑呈对数正态分布的阴影和R^-4规律的路径损失的综合影响,采用与传统不同的小区平均中断概率来评价系统的性能。 相似文献
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锗γ能谱测量中的符合相加修正 总被引:4,自引:1,他引:3
本文介绍了锗γ能谱测量中符合相加修正的原理和方法,给出了修正公式。分别计算了不同几何条件下两个锗探测器对一些放射性核素的符合相加修正因子,估计了符合相加修正因子对活度测量结果的误差贡献。 相似文献
36.
对国产加氢裂化热高分油管线的弯头开裂原因进行了分析 ,对预防连多硫酸腐蚀提出了相应的防范措施 :选用碳含量 <0 .0 3 %并含有稳定化元素Ti、Nb的奥氏体不锈钢或双相钢 ;控制焊缝硬度不大于HB2 0 0并焊后热处理 ;12CrMo和 15CrMo耐应力腐蚀性能好 ;设备停运后马上进行清洗并用碱液中和 相似文献
37.
Tan J.C. Crossley P.A. McLaren P.G. Hall I. Farrell J. Gale P. 《Power Delivery, IEEE Transactions on》2002,17(1):68-74
This paper describes a sequential tripping strategy used in a wide area back-up protection expert system (BPES) to combat situations in which protection relays have maloperated or information is missing. The BPES is an innovative back-up protection scheme designed to prevent the occurrence of widespread blackouts. The BPES evaluates the certainty that transmission lines are likely to be affected by the fault and uses a sequential tripping strategy to isolate the fault if a firm decision is not available due to maloperated relays and/or missing information. The mode of analysis and the sequential tripping strategy ensures that the BPES will clear a fault at minimum risk to the network. An example is included to demonstrate how the certainty factor based sequential tripping strategy is employed by the BPES to clear a fault which occurred on the South Western part of the UK National Grid System 相似文献
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Successful operation of the Synchronous Overlap and Add (SOLA) algorithm for Time Scale Modification (TSM) of speech is closely tied to the proper choice of parameters. This paper investigates the quality of time scale modified speech under different values of primary parameters. Based on Mean Opinion Score (MOS) tests and Bark Spectral Distortion (BSD) measure, the proper choices of synthesis shift (Ss) and the duration of the shift search interval (K max?) are given experimentally. The conclusions can be helpful for operating the SOLA algorithm for time scale modification of speech. 相似文献