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61.
Sisi Zhang Rachel W.S. Chan Ernest H.Y. Ng William S.B. Yeung 《International journal of molecular sciences》2022,23(9)
Human endometrium is an incredibly dynamic tissue undergoing cyclic regeneration and shedding during a woman’s reproductive life. Endometrial mesenchymal stromal/stem-like cells (eMSC) contribute to this process. A hypoxic niche with low oxygen levels has been reported in multiple somatic stem cell types. However, the knowledge of hypoxia on eMSC remains limited. In mice, stromal stem/progenitor cells can be identified by the label-retaining technique. We examined the relationship between the label-retaining stromal cells (LRSC) and hypoxia during tissue breakdown in a mouse model of simulated menses. Our results demonstrated that LRSC resided in a hypoxic microenvironment during endometrial breakdown and early repair. Immunofluorescence staining revealed that the hypoxic-located LRSC underwent proliferation and was highly colocalized with Notch1. In vitro studies illustrated that hypoxia activated Notch signaling in eMSC, leading to enhanced self-renewal, clonogenicity and proliferation of cells. More importantly, HIF-1α played an essential role in the hypoxia-mediated maintenance of eMSC through the activation of Notch signaling. In conclusion, our findings show that some endometrial stem/progenitor cells reside in a hypoxic niche during menstruation, and hypoxia can regulate the self-renewal activity of eMSC via Notch signaling. 相似文献
62.
B. Chai S.-C. Zhang C.-R. Qiu H.-B. Zhang Y.-X. Lai Q. Xin 《Journal of Infrared, Millimeter and Terahertz Waves》2007,28(6):423-432
A linear theory based on Maxwell-Vlasov equations and the Laplace transform is presented to describe the large-orbit coaxial-waveguide cyclotron autoresonance maser (CARM) amplifier. A 35-GHz, TE5,1-mode large-orbit coaxial-waveguide CARM amplifier is specifically analyzed. Good agreement between the linear theory and the nonlinear simulations is found in the exponentially growing region of the wave. Results show that the operating magnetic field and the electron-beam energy and average radius substantially affect the power, and especially, a small beam current may be unsuitable to a large-orbit CARM amplifier operation. 相似文献
63.
Optimization of optical design for developing an LED lens module 总被引:1,自引:0,他引:1
Wen-Chin Chen Kai-Ping Liu Binghui Liu Tung-Tsan Lai 《Neural computing & applications》2013,22(3-4):811-823
In this study, a procedure for optimization of an LED lens module design based on 3 LED light sources was divided into two phases. For preliminary optimization of the dimensions of the LED lens module in Stage I, an optical analysis with orthogonal arrays and TracePro (an optical design package) combined with analysis of variance was conducted to investigate relationships between the multiple optical quality characteristics (viewing angle and average illuminance) and dimension parameters and find the initial optimal parameter combination of the LED lens module. In Stage II, the initial optimal parameter combination determined in Stage I was employed to develop an orthogonal array L25(56) for optical simulation. The experimental data of the orthogonal array were used to train and test the back-propagation neural network to develop an optical quality predictor, which was integrated into the genetic algorithms and the particle swarm optimization in order to find the optimal parameter combination that conformed to optical quality. From the experimental results, the proposed optimization procedure contributes to a precise viewing angle to achieve the goal of optical quality and improved the average illuminance in development of the product. The procedure to optimize the optical design developed in this study can be applied to design all types of LED lens modules and improve the optical design and technology of the LED lens industry. 相似文献
64.
65.
Investigation of growth behavior of Al-Cu intermetallic compounds in Cu wire bonding 总被引:1,自引:0,他引:1
In this work, we investigate the intermetallic compound formation in Cu wire bonded device. Voids near the Cu side at the bond interface are clearly seen. Nevertheless, these voids do not seem to interfere with the function of the unit. High temperature storage test (HTST) results show that there are Al2Cu and AlCu in the damaged unit while Al2Cu and Al4Cu9 appear in the good unit. The results clearly show that the Al layer is exhausted in the damaged unit while those with Al4Cu9 on the Cu side pass HTST with unconsumed Al. Theoretical calculations indicate that AlCu and Al4Cu9 are energetically more favorable than Al2Cu, which is consistent with the reported IMC forming sequence. Formation energy of AlCu is compatible but slightly lower to that of Al4Cu9, suggesting AlCu tends to be the most stable phase among all. The reason why the Al layer is completely consumed in one case and some Al layer remains in the other is due to the fact that the formation of AlCu requires more than twice the amount of Al than Al4Cu9 for the same amount of Cu consumed. The complete consumption of Al is proposed as the reason responsible for the failure of the damaged unit. 相似文献
66.
67.
当前日益激烈的就业竞争压力增大了高职毕业生的就业心理压力,使其产生了各种各样的择业心理问题,本文在初步分析高职毕业生择业心理问题的表现和产生原因的基础上,重点提出了调适择业心理问题的有效方法. 相似文献
68.
When a sensor network is deployed to detect objects penetrating a protected region, it is not necessary to have every point
in the deployment region covered by a sensor. It is enough if the penetrating objects are detected at some point in their
trajectory. If a sensor network guarantees that every penetrating object will be detected by at least k distinct sensors before it crosses the barrier of wireless sensors, we say the network provides k-barrier coverage. In this paper, we develop theoretical foundations for k-barrier coverage. We propose efficient algorithms using which one can quickly determine, after deploying the sensors, whether
the deployment region is k-barrier covered. Next, we establish the optimal deployment pattern to achieve k-barrier coverage when deploying sensors deterministically. Finally, we consider barrier coverage with high probability when
sensors are deployed randomly. The major challenge, when dealing with probabilistic barrier coverage, is to derive critical
conditions using which one can compute the minimum number of sensors needed to ensure barrier coverage with high probability.
Deriving critical conditions for k-barrier coverage is, however, still an open problem. We derive critical conditions for a weaker notion of barrier coverage,
called weak k-barrier coverage. 相似文献
69.
Alexander Gelman Rachel Pasteur Miriam Rave 《Journal of the science of food and agriculture》1990,52(2):231-247
The shelf life and freshness changes in pond-grown common carp (Cyprinus carpio L) during storage at 0–2°C, 5–6°C and room temperature (26–29°C) were investigated by sensory, microbiological, physical and chemical analyses. The effect of gutting on the shelf life during storage at 0–2°C was examined. Iodine/starch and potassium sorbate were examined for their effects on shelf life of whole fish stored at 0–2°C and 5–6°C. Sensory results indicated that the whole fish had a maximum shelf life of 24 to 25 days at 0– 2°C. The life of the fish to the point beyond which it would be unsuitable for sale (commercial shelf life) was 17 days at 0–2°C. Storage at 5–6°C shortened shelf life 2- to 2.5-fold. At room temperature (26–29°C), spoilage was evident after 13 h. Gutting the carp shortened its storage potential at 0–2°C. Iodine treatment of this species stored at 0–2°C and at 5–6°C did not extend shelf life. The maximum shelf life of sorbate-treated fish at 0–2°C and 5–6°C was extended by 1–2 days, commercial shelf life by 3–4 days. Total volatile basic nitrogen, pH and penetrometer analyses were not reliable indicators of changes in freshness during shelf life. Thiobarbituric acid values were not useful as rancid odours or flavours were not detected during storage. 相似文献
70.
FIR数字滤波器的递推最小二乘设计算法 总被引:24,自引:0,他引:24
本文考虑对称系数及反对称系数的FIR数字滤波器的设计问题,设计准则选为最小加权平方误差准则,并将这个设计问题看成一个线性系统的辨识问题,辨识系统参数所需的输入数据由一随机抽样法产生,辨识算法采用递推最小二乘法.按随机抽样法产生的数据具有很强的激励,保证了被辨识参数的收敛性,同时又自然地实现了最小加权平方误差准则.两个设计范例说明了本文提出的设计方法的有效性. 相似文献