纳秒脉冲治疗裸鼠皮下移植瘤抗癌机制研究

本研究探讨了纳秒级陡脉冲(nsPEF)对人恶性黑色素瘤A375细胞裸鼠皮下移植瘤模型可能的抗癌机制.通过用游标卡尺测量裸鼠皮下瘤大小,估算抑瘤率.用琼脂糖凝胶电泳、TUNEL法检测肿瘤细胞在纳秒脉冲电场下的细胞凋亡情况,并用HE染色观察细胞形态变化.通过免疫组化法检测瘤体内微血管密度MVD、微血管形态、血管生长因子VEGF和增殖细胞核抗原PCNA的表达.结果发现nsPEF治疗后4d肿瘤生长抑制率达42.6％,琼脂糖凝胶电泳显示治疗后2h组出现阶梯状分布,治疗后4d组阶梯状分布较之明显,对照组未见阶梯状分布;TUNEL法显示治疗组凋亡率均高于对照组,治疗后4d组凋亡率明显高于2h组(p＜0.01).脉冲处理后见肿瘤区即刻变为灰白色;HE染色发现治疗后2h组肿瘤见少许坏死区域、4d组肿瘤坏死区域增多;免疫组化检测发现治疗后4d组微血管腔闭塞状态、MVD、VEGF及PCNA表达较对照组及治疗后2h组明显增多(P＜0.01),而对照组与治疗后2h组比较差异无统计学意义(P＞0.05).结果表明纳秒级陡脉冲可能通过诱导细胞大量凋亡,短时间内降低肿瘤血流量,降低细胞增殖能力并降低肿瘤血管形成和重塑以防止肿瘤再生等方面发挥其抗癌效应.     

光纤光栅在传感应用中波长漂移的检测方案

波长漂移量的检测是实现光纤光栅传感网络的关键技术。分类阐述了近几年来光纤光栅传感应用中主要的波长检测方案,分析了它们的工作机理和特性,并展望了其可观的应用前景。     

高空电缆防腐蚀润滑脂的研制

为了解决普通防腐蚀润滑脂胶体安定性差的问题,研制了一种高空电缆防腐蚀润滑脂。通过加入胶体安定性改善剂,提高了润滑脂的胶体安定性,钢网分油(120℃,1 h)仅为0.01%。研制的高空电缆防腐蚀润滑脂还具有良好的氧化安定性和抗腐蚀性。一年多的实际使用表明,高空电缆防腐蚀润滑脂可有效地保护高空电缆。高空电缆防腐蚀润滑脂解决了胶体安定性差的问题,达到了研制目的。     

虚源成像观测系统设计方法

虚源成像法可以避开地形起伏和复杂上覆地层对深部地质目标体的影响,提高地震勘探的分辨率和保真度。为了提高虚源成像的质量,在射线分析的基础上,给出了单层水平介质条件下虚源成像观测系统设计的定量表达式,从运动学的角度解释了固定相位点的物理意义,即满足反射波入射角等于直达波入射角的炮检点空间分布。同时,提出了调谐采样间隔的概念,为反射波信息准确重构的定量评价提供了一种有效方法。在此基础上,研究了不同参数对虚源成像质量的影响,其中介质速度和检波点的埋藏深度对成像质量有较大影响,而地质目标体的埋藏深度以及检波点间距对成像质量影响较小。数值试验的结果表明,随着介质速度和检波点埋藏深度的不断增大,调谐采样间隔不断增大,炮间距的选择范围也随之不断增大,进而为虚源成像地震数据采集提供更加高效保真的设计方案。     

辫状河储层构型表征研究进展

储层构型表征是开发后期挖潜剩余油的重要手段,辫状河砂体是重要的油气储层,但由于辫状河沉积机制复杂,砂体叠置关系多样,致使其内部构型模式复杂。针对辫状河储层构型的研究,在野外地质解剖、测井曲线识别、探地雷达分析以及室内模拟实验等多方面均已取得了诸多研究成果。依据储层构型层次界面分析法,辫状河储层构型共划分出6级储层构型单元;其中主要的储层构型研究对象为3级和4级储层构型单元,研究内容为辫状河沉积体系中单砂体的沉积模式、构型参数表征,心滩内部增生体与夹层的发育模式及构型参数特征。辫状河储层构型主要受构造运动、河水能量、气候条件以及沉积基准面变化4个方面的影响。     

基于轻量化智能的多机协同SLAM系统

视觉多机协同即时定位与地图构建(SLAM)主要以相机作为传感器,并通过多机器人合作实现定位与建图。然而,在面对复杂环境时前端计算量过大,易导致整体系统精度不理想。启发于REVO和SVO算法的轻量化特点,提出一种基于轻量化智能的多机协同SLAM系统,旨在降低前端计算资源的同时提升系统可扩展性。提出改进REVO算法—L-REVO,通过轻量化改进实现前端实时运行;将L-REVO融合CCMSLAM系统后端,提出一种完整的多机协同SLAM架构;调整前端传感器和算法,分别验证前端为同构或异构时对系统性能的影响。在公开数据集TUM上,相比CCMSLAM系统,该系统两种模式下定位精度分别提高了59.4%和31.6%,能效比提升了8倍。最后,将该系统用于室内场景实验,前端功耗仅1.43 W,验证了所提系统的可行性和有效性。     

钢铁表面锌系磷化膜的研究

本文采用ＳＥＭ和ＴＥＭ等测试手段，研究了四功能处理液不同条件下在钢铁表面上形成锌系磷化膜的形貌，晶体结构；采用ＥＤＳ研究了磷化膜的化学成发，通过实验确定了Ｚｎ／Ｐ值在２．１２～３．２０时，磷化膜具有良好的耐蚀性。     

Study of the numerical simulation of tight sandstone gas molecular diffusion based on digital core technology

Diffusion is an important mass transfer mode of tight sandstone gas. Since nano-pores are extensively developed in the interior of tight sandstone, a considerable body of research indicates that the type of diffusion is mainly molecular diffusion based on Fick’s law. However, accurate modeling and understanding the physics of gas transport phenomena in nanoporous media is still a challenge for researchers and traditional investigation (analytical and experimental methods) have many limitations in studying the generic behavior. In this paper, we used Nano-CT to observe the pore structures of samples of the tight sandstone of western of Sichuan. Combined with advanced image processing technology, threedimensional distributions of the nanometer-sized pores were reconstructed and a tight sandstone digital core model was built, as well the pore structure parameters were analyzed quantitatively. Based on the digital core model, the diffusion process of methane molecules from a higher concentration area to a lower concentration area was simulated by a finite volume method. Finally, the reservoir’s concentration evolution was visualized and the intrinsic molecular diffusivity tensor which reflects the diffusion capabilities of this rock was calculated. Through comparisons, we found that our calculated result was in good agreement with other empirical results. This study provides a new research method for tight sandstone digital rock physics. It is a foundation for future tight sandstone gas percolation theory and numerical simulation research.     

盐穴储库油水界面测量系统的软件设计

油水界面数据采集软件是基于自行研发的储气库油水界面仪而设计的，可实时、连续采集来自可编程电源的电流、电压信号，实时输出油水界面的深度，从而起到动态监控油水界面位置的功能。文章详细介绍了谊软件的硬件基础、设计思想、结构、主要功能和控制流程等方面的内容，对相关数据采集系统的开发具有一定的参考价值。     

A Study on NMR and GC/MS Spectra of the Isomers of Linear Hexyl Naphthalene

The GC/MS and NMR analysis of the reaction products of naphthalene with 1-bromohexane were reported. The products obtained were suggested to have six isomers of linear hexylnaphthalene and the structure of each isomer was determined by GC/MS and NMR spectra. For the first time, the unique chemical shift data were obtained. The content of each isomer calculated by ¹H NMR and ¹³C NMR spectra was consistent with that by GC/MS spectra, which confirmed the accuracy of NMR data.