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81.
Protoporphyria is a genetic disorder in which patients may develop severe protoporphyrin-induced liver damage and require transplantation. Because unique problems occur in the perioperative period and because excess production of protoporphyrin by the bone marrow continues after liver transplantation, the efficacy of this procedure for protoporphyric liver disease is uncertain. We present follow-up of nine patients who underwent liver transplantation. Two patients died within 2 months of transplantation, one from complications of abdominal bleeding and the other from sepsis after bowel perforations. The remaining seven patients had follow-up at 14 months to 8 years after transplantation (mean, 3.8 years). Two of the seven had suffered skin burns from exposure to operating room lights, which healed without scarring. Three had axonal neuropathies in the postoperative period requiring prolonged mechanical ventilation, and motor defects persisted in two. Five patients had normal liver chemistries at follow-up (mean, 3.5 years), with liver biopsy results normal or showing mild portal triad abnormalities, but erythrocyte protoporphyrin levels remained significantly elevated (1,765 +/- 365 mcg/dL; normal, < 65). The other two patients, both of whom had rejection, cytomegalovirus infection, and biliary tract obstruction requiring endoscopic therapy, had a recurrence of protoporphyric liver disease as indicated by liver biopsy features. One died 5 years after transplantation from complications of the liver disease. The other was stable 3.3 years after transplantation and was being monitored for possible retransplantation. Thus, liver transplantation can be performed successfully in patients with protoporphyric liver disease, with intermediate survival rates comparable to the general transplant population. However, disease may recur in the graft, particularly if there are complications that cause cholestasis. 相似文献
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84.
From the principle of of the Domain Decomposition Method (DDM), we analyse the 2nd-order linear elliptic partial differential problems and link the Separated-Layers Algorithm (SLA) with DDM. The mathematical properties of SLA and numerical example are presented to obtain satisfactory computation results. For general linear differential ones, also are the structure of SLA and its characteristics discussed. 相似文献
85.
激光对CCD器件破坏时几种阈值的测量 总被引:11,自引:1,他引:10
本文简要回顾了近十年来激光CVD(LCVD)技术的发展概况及其在金属、电介质和半导体薄膜生长方面的应用情况。阐明了这种新发展起来的成膜技术不仅因其生长的低温化能够给器件带来优良的电学特性,同时也可利用其高精度的膜厚控制特性获得新结构的材料和器件。作者还对该技术的广泛的应用前景予以展望和肯定。 相似文献
86.
旋风燃烧器冷态模型内颗粒运动轨迹计算 总被引:2,自引:0,他引:2
在冷态模型流场内,考虑气流对粉煤颗粒的气动阻力,建立其运动微分方程式。通过计算,得到九种粒径的颗粒在流场中的运动轨迹、停留时间、着膜位置和气-固相相对速度与该燃烧器几何参数和气动参数的关系,为燃烧器的深入研究提出了建议。 相似文献
87.
Ku is a heterodimeric protein composed of 86 and 70 kDa subunits that binds preferentially to the double-stranded ends of DNA. Recent molecular characterization of ionizing-radiation sensitive (IRs) mutants belonging to the XRCC5 complementation group demonstrated the involvement of Ku in DNA double-strand break (DSB) repair and lymphoid V(D)J recombination. Here, we describe the isolation of a full-length hamster cDNA encoding the large subunit of the Ku heterodimer and demonstrate that the stable expression of this cDNA can functionally restore IR, Ku DNA end-binding activity and V(D)J recombination proficiency in the Chinese hamster IRs sxi-3 mutant. Moreover, we also demonstrate that sxi-3 cells are hypersensitive to etoposide, a DNA topoisomerase II inhibitor, and that resistance to this drug was restored by the Ku86 cDNA. These experiments suggest that a defect in the large subunit of the heterodimeric Ku protein is the sole factor responsible for the known defects of sxi-3 cells and our data of further support the role of Ku in DNA DSB repair and V(D)J recombination. 相似文献
88.
本文简要介绍了在光纤通信、光纤传感和光纤信号处理枝术等各种光纤系统中可能开发应用的固体声光技术和光纤声光技术。 相似文献
89.
何此昂 《单片机与嵌入式系统应用》2007,(1):76-78
Freescale公司的MC68HC908JB8(简称"JB8")是HC908系列中的一种.它包括USB接口,是专为计算机人机接口设备设计的,诸如鼠标、键盘等应用.JB8包含8 KB的Flash用户存储区和16字节的中断复位向量,使用它内部产生的升压泵就可以实现Flash的烧写和擦除,而不需要高电压. 相似文献
90.
JS Plummer KA Berryman C Cai WL Cody J DiMaio AM Doherty JJ Edmunds JX He DR Holland S Levesque DR Kent LS Narasimhan JR Rubin ST Rapundalo MA Siddiqui AJ Susser Y St-Denis PD Winocour 《Canadian Metallurgical Quarterly》1998,8(23):3409-3414
The synthesis and antithrombotic activity of a series of nonpeptide bicyclic thrombin inhibitors is described. We have explored the SAR with modifications to the P1 site. The introduction of arginine mimetics at the P1 site led to potent and selective thrombin inhibitors. 相似文献