Stereospecific determinations of (+/- )-DU-124884 and its metabolites (+/- )-KC-9048 in human plasma by liquid chromatography

Fifty-one young diabetics responded to a questionnaire concerning compliance and were interviewed on two topics: the meaning of care to the subjects and the nature of their support system. Diabetes control was measured by glycosylated haemoglobin (GHB). Interview data were analysed by continuous comparative analyses. The categories obtained were quantified and the relationship between variables analysed by cross tabulation, chi-square test and discriminant analysis. Those who responded with a good compliance showed good control of diabetes as indicated by GHB values and reported sufficient energy and will-power to implement the health regimens. Those young people who reported that they had sufficient energy and will-power considered care important, received encouragement, felt that care brings well-being and had no fears of complications.     

Cardiac troponin T and cardiac troponin I: relative values in short-term risk stratification of patients with acute coronary syndromes. GUSTO-IIa Investigators

We compared cardiac troponins T (cTnT) and I (cTnI) collected within 3.5 h of ischemic symptoms for predicting clinical outcomes in 770 patients. cTnT (cutoff > 0.1 microgram/L) and cTnI (cutoff > 1.5 micrograms/L) were concordant (both positive or negative) in 90.4% of patients. Among discordant results, 66 were cTnT positive and cTnI negative vs 8 who showed the reverse (P < 0.001). Five cTnT-positive and cTnI-negative patients died within 30 days; none who were cTnT negative and cTnI positive died. cTnT showed a slightly greater association (chi 2 = 18.0, P < 0.001) with 30-day mortality than cTnI (chi 2 = 12.5, P = 0.002). The area of the ROC curve for predicting 30-day mortality was significantly larger (Z = 2.08; P = 0.0375) for cTnT, at 0.68 [95% confidence interval (CI) 0.60-0.75], compared with cTnI, at 0.64 (95% CI 0.56-0.72). When cTnI and the electrocardiogram (ECG) were put in a logistic multiple regression model, cTnT added significant information (chi 2 = 8.03, P = 0.045); however, cTnI did not add to a model containing cTnT and the ECG (chi 2 = 0.84, P = 0.657). cTnT provided more information than cTnI for predicting 30-day mortality early after presentation with acute coronary syndromes.     

Sudden parotid swelling due to spontaneous haemorrhage

BACKGROUND: To evaluate the implementation of nuchal translucency measurement as an additional examination within the first trimester routine ultrasound in an unselected population of women. METHODS: A prospective study in which all pregnant women during 1994, referred for the first trimester routine ultrasound scan, were asked to participate. Of a total of 1852 women with a viable pregnancy, results from 1444 women were evaluated. When a nuchal translucency of 4 mm or more was found, the woman was offered both a genetic amniocentesis in gestational week 13-15 and an additional ultrasound examination in gestational week 18-19. RESULTS: Six fetuses had a nuchal translucency of 4 mm or more and none of these had any chromosomal abnormality. Neither had any of the fetuses in the study, karyotyped for other reasons, any chromosomal defect and nor was there any child born with aneuploidy in the study population. No strong relation between major malformations e.g. abnormalities of the heart and increased nuchal translucency was found. The fetus with the largest nuchal translucency (=6 mm) was born healthy. CONCLUSION: The efficacy of nuchal translucency measurement needs further evaluation before it can be introduced as a screening method in an unselected pregnant population.     

Pulmonary sequestration: six unusual presentations

In a review of 26 cases of sequestration, six patients with unusual radiographic features are described in detail. Three children had congestive heart failure, and congenital heart disease was suspected. One patient with a cystic upper lobe sequestration was thought to have a pneumatocele or infected cyst. In two other cases the sequestrations had features of a solid mass lesion. One of these was erroneously diagnosed as a mesothelioma or bronchogenic cyst, and the other as a carcinoma.     

Lattice vibrational waves in cubic crystal plates

Summary An investigation is given of the lowest symmetric (extensional) and the lowest antisymmetric (flexural) mode of waves in a cubic crystal plate bounded by two planes of symmetry. The investigation was carried out using the continuum theory of anisotropic elasticity, and also using a simple cubic lattice model. Particular attention was given to the change of the character of both the extensional and flexural mode, which takes place as the wave length is decreased from infinity down to values of the order of the plate thickness. Both modes tend to become surface modes whenever surface waves are possible along the direction of propagation. However, some essential differences were observed, regarding this transition from bulk modes to surface modes, between materials which propagateRayleigh surface waves and those which propagate generalizedRayleigh surface waves.

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Zusammenfassung Es werden die niedrigsten Schwingungsformen in einem kubischen Plattenkristall, der von zwei Symmetrieebenen begrenzt wird, untersucht, und zwar sowohl die symmetrische (Dehnungs-) als auch die antisymmetrische (Biegungs-) Schwingung. Die Untersuchung wird mit Hilfe der Kontinuumstheorie anisotroper elastischer Medien sowie unter Verwendung des Modells eines einfachen kubischen Gitters durchgeführt. Besondere Aufmerksamkeit wird der Änderung des Charakters der Dehnungs- und der Biegeschwingung gewidmet, welche bei Verkleinerung der Wellenlänge von sehr großen Werten auf solche von der Größenordnung der Plattendicke auftritt. Beide Wellenarten haben das Bestreben, Oberflächenwellen zu werden, solange das Auftreten von Oberflächenwelles in der Ausbreitungsrichtung möglich ist. Es werden aber einige wesentliche Unterschiede beim Übergang von Körperwellen zu Oberflächenwellen beobachtet, je nachdem, ob es sich um Stoffe handelt, in denenRayleighsche Oberflächenwellen oder solche, in denen verallgemeinerteRayleighsche Oberflächenwellen entstehen.

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With 4 Figures