Pulse height defect in pCVD and scCVD diamond based detectors

Polycrystalline (pCVD) and single crystal (scCVD) diamond films grown from Chemical Vapour Deposition (CVD), if sufficiently pure at Raman analysis, are very good materials for beam or flux monitors inside accelerators or nuclear reactors. This is because they are very hard to damage in high radiation fields and very resistant to high temperatures. Films of pCVD diamond are, however, not so good as spectroscopy detectors due to inhomogeneities induced by their growth in grains with the consequent presence of grain boundaries which worsen their energy resolution. The latter can be significantly improved by growing scCVD diamond films onto HPHT synthetic diamond substrates. We have shown that it is possible to measure the density of defects inside diamond specimens using as probes suitable penetrating nuclear radiations. With the preliminary results reported here we'll show that, bombarding CVD diamond films grown at Roma “Tor Vergata” with energetic protons and ⁴He, ⁶Li and ¹²C ions produced in the accelerators of Catania laboratories, the pulse height defects are higher than those in silicon detectors and likewise well described by a power law in the deposited energy. Furthermore, we'll show that pulse heights for the same particles seem to depend on the duration of the measurement, thus exhibiting a sort of depolarization of the insulator when exposed to the electric voltage which makes it a particle detector.     

Differential behavioral response to dopamine D? agonists by sexually naive, sexually active, and sexually inactive male rats.

This study was performed with male rats categorized as sexually active (SN), sexually active (SA). or sexually inactive (SI). In a first experiment the effects of the dopamine (DA) D? agonist SND 919 (0.05, 1, and 10 mg/kg) on the copulatory behavior of SN, SA. and SI rats were assessed. In a second experiment the DA D? agonist B-HT 920 (0.2 mg/kg) was used, and examination was limited to SN and SA rats. The effects exerted on stretching-yawning, penile erection, and sedation by the same compounds at the same doses in these three rat categories were also investigated. The main findings were that SND 919 and B-HT 920 facilitated ejaculation in SA rats, and that the rats that were different as regards level of sexual activity exhibited different behavioral responses to the two DA agonists. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Printing nano TiO2 on large-sized building materials: Technologies,surface modifications and functional behaviour

The industrial feasibility of large-sized, photocatalytic building materials was assessed by the adoption of suitable, fast and environmental friendly technological solutions. Nanostructured TiO₂ coatings can be realized by ink-jet or roller printing of nano-anatase suspensions by modifying, in one single step, the chemistry and microstructural features of products. Functional coatings must be consolidated through additional thermal steps, which necessarily entail modifications of the current production cycles of ceramic tiles. This is due to the fact that the direct functionalization of unfired ceramics is detrimental to the photocatalytic performance. The microstructure of coatings depends on deposition technologies and processing conditions. However, photoactive materials that also display superhydrophilic behaviour can be obtained by employing much lower amounts of TiO₂ than 1.0 g m^?2, and by annealing at temperature as low as 400–500 °C. A limited increase of the cost of products is involved, especially in the case of large-sized elements.     

Decomposing regional business change at plant level in Italy: A novel spatial shift‐share approach

In this paper, spatial shift‐share decomposition is analysed when applied to Italian data on regional business change at plant level, over the period 2004–2009. A new type of spatial decomposition, which looks more effectively at neighbourhood influence, is introduced here. Notable results emerge from the empirical investigation. First, it can be seen that the spatial level of aggregation greatly affects results. Second, evidence of neighbourhood advantage in the Southern NUTS 3 regions is found, together with opposite results for the Central‐Northern NUTS 3 regions. Finally, evidence of positive industrial mix effects is only found in Central‐Northern Italy.     

Evaluation of the tamper-resistant properties of biphasic immediate-release/extended-release oxycodone/acetaminophen tablets

Context: Abuse potential of extended-release (ER) opioid tablets increases if tampering causes rapid opioid release.

Objective: To evaluate the susceptibility to tampering of biphasic immediate-release (IR)/ER oxycodone (OC)/acetaminophen (APAP) tablets compared with IR OC/APAP tablets.

Materials and methods: IR/ER OC/APAP and IR OC/APAP tablets were tested at room temperature and after heating, freezing and microwaving. Resistance to crushing was tested using manual and powered tools (e.g. spoons, mortar and pestle, blender, coffee grinder). Tampered tablets were tested for suitability for snorting, OC extraction in solvents and ease of drawing into a syringe. Dissolution of IR/ER OC/APAP in gastric fluid with and without ethanol was tested to determine the potential for facilitating precipitous release of opioid from the tablet.

Results: IR/ER OC/APAP tablets were more crush resistant than IR OC/APAP tablets. Heating, freezing and microwaving had no effect on crush resistance of IR/ER OC/APAP tablets. Although a mortar and pestle pulverized IR/ER OC/APAP tablets, upon contact with solvent, the powder formed a thick gel judged unsuitable for absorption through the nasal mucosa and could not be drawn into a syringe. In contrast, powder from crushed IR OC/APAP tablets dissolved readily, was judged suitable for snorting, and was easily drawn into a syringe. Dissolution of IR/ER OC/APAP tablets in gastric fluid was slowed by the addition of ethanol.

Discussion: IR/ER OC/APAP tablets are resistant to crushing and dissolution compared with IR OC/APAP tablets.

Conclusion: IR/ER OC/APAP tablets may have less potential for abuse involving tampering compared with IR OC/APAP tablets.     

The effect of nanoscale surface curvature on the oligomerization of surface-bound proteins

The influence of surface topography on protein conformation and association is used routinely in biological cells to orchestrate and coordinate biomolecular events. In the laboratory, controlling the surface curvature at the nanoscale offers new possibilities for manipulating protein–protein interactions and protein function at surfaces. We have studied the effect of surface curvature on the association of two proteins, α-lactalbumin (α-LA) and β-lactoglobulin (β-LG), which perform their function at the oil–water interface in milk emulsions. To control the surface curvature at the nanoscale, we have used a combination of polystyrene (PS) nanoparticles (NPs) and ultrathin PS films to fabricate chemically pure, hydrophobic surfaces that are highly curved and are stable in aqueous buffer. We have used single-molecule force spectroscopy to measure the contour lengths L_c for α-LA and β-LG adsorbed on highly curved PS surfaces (NP diameters of 27 and 50 nm, capped with a 10 nm thick PS film), and we have compared these values in situ with those measured for the same proteins adsorbed onto flat PS surfaces in the same samples. The L_c distributions for β-LG adsorbed onto a flat PS surface contain monomer and dimer peaks at 60 and 120 nm, respectively, while α-LA contains a large monomer peak near 50 nm and a dimer peak at 100 nm, with a tail extending out to 200 nm, corresponding to higher order oligomers, e.g. trimers and tetramers. When β-LG or α-LA is adsorbed onto the most highly curved surfaces, both monomer peaks are shifted to much smaller values of L_c. Furthermore, for β-LG, the dimer peak is strongly suppressed on the highly curved surface, whereas for α-LA the trimer and tetramer tail is suppressed with no significant change in the dimer peak. For both proteins, the number of higher order oligomers is significantly reduced as the curvature of the underlying surface is increased. These results suggest that the surface curvature provides a new method of manipulating protein–protein interactions and controlling the association of adsorbed proteins, with applications to the development of novel biosensors.     

An Improved ZnMoO4 Scintillating Bolometer for the Search for Neutrinoless Double Beta Decay of 100Mo

We present a prototype scintillating bolometer for the search for neutrinoless double β decay of ¹⁰⁰Mo, consisting of a single ≈5?g ZnMoO₄ crystal operated aboveground in the 20–30?mK temperature range. The scintillation light is read out by two thin Ge bolometers. The phonon signals are collected by NTD Ge thermistors. The ZnMoO₄ crystal was grown with an advanced method (low-thermal-gradient Czochralski technique) and after purification of molybdenum. The results are very encouraging: the intrinsic energy resolution of the heat channel is ≈800?eV FWHM, the α/β rejection factor (crucial for background suppression) is better than 99.9% in the region of interest for double β decay (≈3?MeV), and the radiopurity of ZnMoO₄ looks substantially improved with respect to previous devices.     

A multiscale flaw detection algorithm based on XFEM

We present a novel multiscale algorithm for nondestructive detection of multiple flaws in structures, within an inverse problem type setting. The key idea is to apply a two‐step optimization scheme, where first rough flaw locations are quickly determined, and then, fine tuning is applied in these localized subdomains to obtain global convergence to the true flaws. The two‐step framework combines the strengths of heuristic and gradient‐based optimization methods. The first phase employs a discrete‐type optimization in which the optimizer is limited to specific flaw locations and shapes, thus converting a continuous optimization problem in the entire domain into a coarse discrete optimization problem with limited number of choices. To this end, we develop a special algorithm called discrete artificial bee colony. The second phase employs a gradient‐based optimization of the Broyden–Fletcher–Goldfarb–Shanno type on local well‐defined and bounded subdomains determined in the previous phase. A semi‐analytical approach is developed to compute the stiffness derivative associated with the evaluation of objective function gradients. The eXtended FEM (XFEM), with both circular and elliptical void enrichment functions, is used to solve the forward problem and alleviate the costly remeshing of every candidate flaw, in both optimization steps. The multiscale algorithm is tested on several benchmark examples to identify various numbers and types of flaws with arbitrary shapes and sizes (e.g., cracks, voids, and their combination), without knowing the number of flaws beforehand. We study the size effect of the pseudo grids in the first optimization step and consider the effect of modeling error and measurement noise. The results are compared with the previous work that employed a single continuous optimization scheme (XFEM–genetic algorithm and XFEM–artificial bee colony methods). We illustrate that the proposed methodology is robust, yields accurate flaw detection results, and in particular leads to significant improvements in convergence rates compared with the previous work. Copyright © 2014 John Wiley & Sons, Ltd.