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111.
Selvam Sivasankari Rajappan Kalaivizhi Natesan Gowriboy Munuswamy Ramanujam Ganesh Musthafa Shazia Anjum 《Polymer Composites》2021,42(10):5512-5526
In this study, we describe the experience of a simple, cost-efficient preparation and characterization of hydroxyapatite (HA) nanomaterial incorporated cellulose acetate/polyetherimide membrane for adsorption and biomedical applications. A simple chemical precipitation technique has been used for the synthesis of HA nanoparticles. The membrane was then developed by incorporating nanoparticles into different compositions of cellulose acetate and polyetherimide by using a phase inversion technique. Fourier transmission infrared spectroscopy, X-ray diffraction spectroscopy, high-resolution transmission electron microscope, field emission scanning electron microscope, and energy dispersive X-ray spectroscopy were used to characterize the structural analysis and morphology of the nanoparticles and polymer membrane. Thermo gravimetric analysis was used to describe thermal characteristics. The contact angle value and wettability test were used to determine the hydrophilicity of the polymer membrane. The images from the scanning electron microscope analysis indicate that the addition of hydroxyapatite nanoparticles causes significant morphological changes in the membrane's surface and cross section. When compared with a control membrane, the presence of inorganic nanoparticles elucidated the impact on thermal and hydrophilic properties. The CA/PEI/HA membrane can be used as an adsorbent material in dye adsorption experiments with model dyes such as Malachite green, Methylene blue as cationic dyes, and Eriochrome black T, Congo red as anionic dyes. In addition, the biocompatibility of the CA/PEI/HA membrane was tested using cell cytotoxicity against THP-1 human monocytic leukemia cells. 相似文献
112.
Corrine A. Nief Alana Gonzales Erika Chelales Júlia Sroda Agudogo Brian T. Crouch Smita K. Nair Nirmala Ramanujam 《International journal of molecular sciences》2022,23(15)
Triple-negative breast cancer (TNBC) is an immunologically heterogenous disease that lacks clinically actionable targets and is more likely to progress to metastatic disease than other types of breast cancer. Tumor ablation has been used to increase response rates to checkpoint inhibitors, which remain low for TNBC patients. We hypothesized that tumor ablation could produce an anti-tumor response without using checkpoint inhibitors if immunosuppression (i.e., Tregs, tumor acidosis) was subdued. Tumors were primed with sodium bicarbonate (200 mM p.o.) to reduce tumor acidosis and low-dose cyclophosphamide (100–200 mg/kg i.p.) to deplete regulatory T cells, as has been shown independently in previous studies. A novel injectable ablative was then used to necrose the tumor, release tumor antigens, and initiate an immune event that could create an abscopal effect. This combination of bicarbonate, cyclophosphamide, and ablation, called “BiCyclA”, was tested in three syngeneic models of TNBC: E0771 (C57BL/6), 67NR (BALB/c), and 4T1-Luc (BALB/c). In E0771 and 67NR, BiCyclA therapy significantly reduced tumor growth and cured 5/7 and 6/10 mice 50 days after treatment respectively. In the metastatic 4T1-Luc tumors, for which surgery and checkpoint inhibitors fail, BiCyclA cured 5/10 mice of primary tumors and lung metastases. Notably, CD4+ and CD8+ T cells were found to be crucial for the anti-metastatic response, and cured mice were able to resist tumor rechallenge, suggesting production of immune memory. Reduction of tumor acidity and regulatory T cells with ablation is a simple yet effective therapy for local and systemic tumor control with broad applicability as it is not limited by expensive supplies. 相似文献
113.
We investigate the semantics of messages, and argue that the meaning ofa message is naturally and usefully given in terms of how it affects theknowledge of the agents involved in the communication. We note thatthis semantics depends on the protocol used by the agents, and thus not only the message itself, but also the protocol appears as a parameter in the meaning. Understanding this dependence allows us to give formal explanations of a wide variety of notions including language dependence, implicature, and the amount of information in a message. 相似文献
114.
Urethral duplication (UD) is an uncommon malformation. Obstruction rarely occurs in hypospadiac UD. We describe two children with incomplete hypospadiac UD in association with posterior urethral valves, a combination not previously recognised. The embryonic significance of this anomaly is discussed. Keywords Urethral duplication. Hypospadias. Posterior urethral valve. Megalourethra 相似文献
115.
We investigate parameters associated with optical data storage in a variety of amorphous side-chain azobenzene-containing polyesters denoted as E1aX. The polyesters possess a common cyano-substituted azobenzene chromophore as a side chain, but differ in their main-chain polyester composition. Seventeen different polymers from the E1aX family divided into four classes, depending on the type of the main-chain substituent (one-, two-, and three-ring aromatic or alicyclic) have been thoroughly investigated. Various parameters characterizing the photoinduced birefringence in these materials, such as the response time, thermal and light stability, and long-term stability under ambient light at room temperature have been measured. Each of these parameters is quantitatively represented and therefore it is possible to make a clear comparison between the properties of the polymers. The results indicate that the long-term stability at ambient temperature is closely related to the thermal stability of the photoinduced birefringence. A strong correlation has also been found between the response time and the stability of the induced anisotropy toward illumination with unpolarized white light. One of the classes of E1aX polymers characterized by two-ring aromatic substituent in the main chain is a good candidate for optical data storage media. A recording energy of approximately 2 J/cm2 is sufficient to induce high refractive-index modulations of deltan = 0.13 in these materials, which is retained even at elevated temperatures (>130 degrees C). Long-term stability of greater than one year for the induced anisotropy has also been achieved. 相似文献
116.
Lazebnik M Zhu C Palmer GM Harter J Sewall S Ramanujam N Hagness SC 《IEEE transactions on bio-medical engineering》2008,55(10):2444-2451
117.
Kandemir M. Choudhary A. Banerjee P. Ramanujam J. Shenoy N. 《Parallel and Distributed Systems, IEEE Transactions on》2000,11(12):1232-1251
Minimizing communication and synchronization costs is crucial to the realization of the performance potential of parallel computers. This paper presents a general technique which uses a global data-flow framework to optimize communication and synchronization in the context of the one-way communication model. In contrast to the conventional send/receive message-passing communication model, one-way communication is a new paradigm that decouples message transmission and synchronization. In parallel machines with appropriate low-level support, this may open up new opportunities not only to further optimize communication, but also to reduce the synchronization overhead. We present optimization techniques using our framework for eliminating redundant data communication and synchronization operations. Our approach works with the most general data alignments and distributions in languages like High Performance Fortran (HPF) and uses a combination of the traditional data-flow analysis and polyhedral algebra. Empirical results for several scientific benchmarks on a Cray T3E multiprocessor machine demonstrate that our approach is successful in reducing the number of data (communication) and synchronization messages, thereby reducing the overall execution times 相似文献
118.
Arrays are mapped to processors through a two-step process—alignment followed by distribution—in data-parallel languages such as High Performance Fortran. This process of mapping creates disjoint pieces of the array that are locally owned by each processor. An HPF compiler that generates code for array statements must compute the sequence of local memory addresses accessed by each processor and the sequence of sends and receives for a given processor to access nonlocal data. In this paper, we present an approach to the address sequence generation problem using the theory of integer lattices. The set of elements referenced can be generated by integer linear combinations of basis vectors. Unlike other work on this problem, we derive closed form expressions for the basis vectors as a function of the mapping of data. Using these basis vectors and exploiting the fact that there is a repeating pattern in the access sequence, we derive highly optimized code that generates the pattern at runtime. The code generated uses table-lookup of the pattern. Experimental results show that our approach is faster than other solutions to this problem. 相似文献
119.
Thermally sprayed coatings are frequently subjected to impacts by small solid particles which induce surface erosion. To identify the physical mechanisms associated with such a material removal process, experimental tests as well as detailed computational analyses of porous coatings containing multiple phases are performed. In the experiments, a gas jet erosion test is conducted to measure material loss of coatings with different mixtures of brittle and ductile phases. The results show higher erosion resistances with small volume fractions of metal phase added to predominantly brittle coatings. Following this outcome, the study is directed toward elucidating the physical mechanisms behind the increased erosion resistance. Here, solid particle impacts are simulated with dynamic finite element analyses where material removals and coating's energy absorption behaviors are closely monitored. Furthermore, parametric study is carried out to quantify effects of cracking resistances and plastic dissipation on the erosion rate. The results reveal synergistic effects of fracture energy and plastic deformation. The combined mechanisms allow greater energy absorptions and enhanced erosion resistance in coatings with mixture of ductile phase. These assessments should offer insights into tailoring coatings with optimized composition of ductile phase to increase their performances. The results are also valuable in understanding foreign object damage (FOD) of coatings. 相似文献
120.