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71.
Jonathan D. Rupp Carol A.C. Flannagan Carrie N. Hoff Rebecca M. Cunningham 《Accident; analysis and prevention》2010,42(6):2140-2143
Older occupants in motor-vehicle crashes are more likely to experience injury than younger occupants. One possible reason for this is that increasing age is associated with increased prevalence of osteoporosis, which decreases bone strength.Crash-injury data were used with Bayes’ Theorem to estimate the conditional probability of AIS 3+ skeletal injury given that an occupant is osteoporotic for the injury to the head, spine, thorax, lower extremities, and upper extremities. This requires the conditional probabilities of osteoporosis given AIS 3+ injury for each of the body regions, which were determined from analysis of the Crash Injury Research and Engineering Network database. It also requires information on probability of osteoporosis in the crash-involved population and the probabilities of AIS 3+ skeletal injury to different body regions in crashes. The latter probabilities were obtained from the National Automotive Sampling System-Crashworthiness Data System (NASS-CDS) database. The former was obtained by modeling the probability of osteoporosis in the US populations using data from the 2006 National Health Examination Nutrition Survey and applying this model to the estimate of the crash-involved population in NASS-CDS. To attempt to account for the effects of age on injury outcome that are independent of osteoporosis, only data from occupants who were 60 years of age or older were used in all analyses.Results indicate that the only body region that experiences a statistically significant change in fracture injury risk with osteoporosis is the spine, for which osteoporosis increases the risk of AIS 3+ fracture by 3.28 times, or from 0.41% to 1.34% (p < 0.0001). This finding suggests that the increase in AIS 3+ injury risk with age for non-spine injuries is likely influenced by factors other than osteoporosis. 相似文献
72.
Charlton Rebecca A.; Barrick Thomas R.; Markus Hugh S.; Morris Robin G. 《Canadian Metallurgical Quarterly》2009,24(2):338
The study investigated age-related differences in theory of mind and explored the relationship between this ability, other cognitive abilities, and structural brain measures. A cohort of 106 adults (ages 50–90 years) was recruited. Participants completed tests of theory of mind, verbal and performance intelligence, executive function, and information processing speed and underwent structural magnetic resonance imaging (measurement of whole brain volume, volume of white matter hyperintensities, and diffusion tensor imaging of white matter integrity). Theory of mind ability declined with increasing age, and the relationship between theory of mind and age was fully mediated by performance intelligence, executive function, and information processing speed and was partially mediated by verbal intelligence. Theory of mind performance correlated significantly with diffusion tensor imaging measures of white matter integrity but not with volume of white matter hyperintensities or whole-brain volume. Theory of mind age-related decline may not be independent of other cognitive functions; it may also be particularly susceptible to changes in white matter integrity. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Rebecca Kokkinofta Charalambos Fotakis Maria Zervou Panagiotis Zoumpoulakis Chara Savvidou Konstantina Poulli Charalambos Louka Naso Economidou Eleni Tzioni Katerina Damianou Sofia Loupasaki Panagiotis Kefalas 《Food Analytical Methods》2017,10(12):3902-3913
This study monitors variations in isotopes and elements in relation to grape variety, environmental factors and provenance in order to address the wine authenticity issue. Inductively coupled plasma atomic emission spectroscopy (ICP-AES) assessed the wines’ elemental content. Site-specific nuclear isotope fractionation-nuclear magnetic resonance and isotope ratio mass spectrometry methodologies determined in authentic and commercial wines the distribution of the naturally occurring stable isotopes of the deuterium/hydrogen (D/H) ratios and carbon (13C/12C) in ethanol of wine and oxygen ratio (18O/16O) in wine water. Chemometrics delineated the elements and isotopes responsible for wine classification. Specifically, unsupervised principal component analysis (PCA) framed the importance of grape variety and provenance, while supervised analysis pinpointed the vineyard effect and highlighted the contribution of the vintage year. Validation steps ensured that the extracted models do not predict randomly and their results are reliable. In fact, the acquired results can be incorporated to the EU Wine Isotopic Databank database providing both a guide and a tool for eventual candidatures for denomination of origin and support both Cypriot wine and winemakers. In this context, this research contributes to authenticity assurance of wines and adds value to final products, while it helps controlling hazards arising from environmental changes. 相似文献
75.
Semi-interpenetrating networks (sIPNs) designed to mimic extracellular matrix via covalent crosslinking of poly(ethylene glycol)
diacrylate in the presence of gelatin have been shown to aid in wound healing, particularly when loaded with soluble factors.
Ideal systems for tissue repair permit an effective release of therapeutic agents and flow of nutrients to proliferating cells.
Appropriate network characterization can, consequently, be used to convey an understanding of the mass transfer kinetics necessary
for materials to aid in the wound healing process. Solute transport from and through sIPNs has not yet been thoroughly evaluated.
In the current study, the diffusivity of growth factors and nutrients through the polymeric system was determined. Transport
of keratinocyte growth factor was modeled by treating the sIPN as a plane sheet into which the protein was loaded. The diffusion
coefficient was determined to be 4.86 × 10−9 ± 1.86 × 10−12 cm2/s. Glucose transport was modeled as flow through a semi-permeable membrane. Using lag-time analysis, the diffusion coefficient
was calculated to be 2.25 × 10−6 ± 1.98 × 10−7 cm2/s. The results were evaluated in conjunction with previous studies on controlled drug release from sIPNs. As expected from
Einstein-Stokes equation, diffusivity decreased as molecular size increased. The results offer insight into the structure-function
design paradigm and show that release from the polymeric system is diffusion controlled, rather than dissolution controlled. 相似文献
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Becoming a better designer means getting better at what we do now while not getting lulled into accepting the status quo. To stay effective as designers, we need to continue to learn, adapt, keep an open mind, and work to perfect our craft. 相似文献
79.
Rebecca L. H. Chiu 《Urban Policy and Research》2013,31(4):455-468
Abstract Marketisation and privatization reforms implemented in Shanghai since 1980 have facilitated housing construction and the improvement of housing conditions. The multiplication of construction capital would have been impossible without an effective implementation of the consumption reforms and general improvements in the economy. 相似文献
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