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91.
Rats were trained to discriminate 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, 0.1 mg/kg i.p.) or 5-methoxy-N,N-dimethyltryptamine (5-OMe-DMT, 1.25 mg/kg i.p.), a selective and nonselective 5-hydroxytryptamine1A (5-HT, serotonin) receptor agonist, respectively, from saline in a two-lever procedure. The selective 5-HT1A receptor agonist ipsapirone substituted completely for 8-OH-DPAT (ED50, 1.52 mg/kg) and 5-OMe-DMT substituted partially for 8-OH-DPAT, whereas 8-OH-DPAT (ED50, 0.07 mg/kg) and ipsapirone (ED50, 4.15 mg/kg) substituted completely for 5-OMe-DMT. These results suggest that the discriminative stimulus properties of both 8-OH-DPAT and 5-OMe-DMT are 5-HT1A receptor mediated, although 5-OMe-DMT may involve an additional interaction with other 5-HT receptor subtypes. 5-OMe-DMT substituted for 8-OH-DPAT after application in the lateral ventricle (ED50, 3.0 micrograms/rat) and the dorsal raphe nucleus (DRN, 1.1 micrograms/rat). After application in the DRN (ED50 range, 1.4-5.0 micrograms/rat) and the median raphe nucleus (2.3 micrograms/rat), and after bilateral application into the CA-4 region of the dorsal hippocampus (4.1 micrograms/rat), 8-OH-DPAT also produced responding on the 8-OH-DPAT lever. Ipsapirone also substituted for 8-OH-DPAT after application into the DRN and the hippocampus (ED50S, 38 and 62 micrograms/rat, respectively). The 5-HT1A mixed agonist-antagonist (1-(2-methoxyphenyl) 4-[4-(2-pthalimido)butyl]piperazine, i.p. NAN-190) attenuated the discriminative stimulus effects of 8-OH-DPAT injected i.p. (0.1 mg/kg), into the DRN (10 micrograms) or into the hippocampus (2 x 10 micrograms).(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
92.
Designing a Production Line to Maximize Profit 总被引:1,自引:0,他引:1
The relationship between profitability and efficiency in a production line is discussed at length for the continuous production model. We prove that a solution which maximizes efficiency will not necessarily maximize profit. Several useful relationships between profitability and efficiency are developed which can greatly enhance computational efficiency. A solution procedure is developed which will determine the optimal number of work stations by maximizing an assumed profit function. An example is provided to illustrate these relationships and the entire solution procedure. 相似文献
93.
Both neuropsychology and psychology in general have been enhanced markedly by brain–behavior models derived from the study of the epilepsies. A significant body of neuropsychological concepts originated or were confirmed through epilepsy-based treatment and research. These concepts include the peri-Rolandic homunculus, the role of the hippocampal–temporal lobe complex in cognitive memory, hemisphere plasticity for speech in childhood, the intracarotid amytal procedure for determining hemisphere memory patency, and hemisphere-based models of cognition confirmed through human commissurotomy. Personality and social–emotional research in epilepsy are additional areas in which new conceptual models grounded in psychological science can both repay our debt to the epilepsies and provide much needed psychological research and treatment. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
94.
Robert A. Zawacki 《Information Systems Management》1992,9(2):73-75
What is the most critical personnel issue of the rest of this decade? To keep programmers, analysts, and developers motivated in their work so they will continue to be productive members of the IS staff. Managers can achieve this by giving proper feedback and by creating a clear career path for IS staff members to grow and contribute their talents to the organization. 相似文献
95.
The author explored the mathematics efficacy beliefs of 270 South Asian (Indo Canadian) immigrant and Anglo Canadian nonimmigrant Grade 7 students. Self-efficacy beliefs strongly predicted mathematics performance for both cultural groups, but there were differences between the 2 groups in the sources of self-efficacy, the predictiveness of the secondary motivation variables, and the vertical dimensions of individualism and collectivism. It is argued that the Indo Canadian students are more vertical or hierarchical than the Anglo Canadian students and that comparison with others strongly influences their motivation beliefs and the formation of their efficacy beliefs. Self-efficacy in some cultures may be more other-oriented than is typically seen in Western cultures. A caution against generalizing about Asian populations is given, and implications for school settings are explored. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
96.
Les Hatton Andy Wright Stuart Smith Gregg Parkes Paddy Bennett Robert Laws 《Software》1988,18(4):301-329
The portability of software has become a major commercial issue in recent times. Such portability does not come easily, as few if any computer languages are really portable in practice. An additional complicating factor, especially in the commercial environment, is that the resulting software must be efficient. This paper describes the design and successful implementation of a 500,000+ line portable FORTRAN 77 package for the processing of seismic data. The package exhibits demonstrably high efficiency on a wide variety of machines from minicomputers to the largest supercomputers. Experiences gained during this exercise throw much light on the integration of the various thought processes which occur during the software engineering cycle, especially the notion of locality. 相似文献
97.
Grant Igor; Olshen Richard A.; Atkinson J. Hampton; Heaton Robert K.; Nelson Julie; McCutchan J. Allen; Weinrich James D. 《Canadian Metallurgical Quarterly》1993,7(1):53
The relationship of depressed mood to cognitive disturbance in HIV infection was examined in a sample of 139 homosexual men. Ss were grouped according to the classification of the Centers for Disease Control: 39 were in Group IV, 62 were in Group II or Group III, and 38 were HIV-negative. Ss completed the Profile of Mood States and 10 neuropsychological tests. Analysis employing a classification approach indicated that, although symptoms of depression and neuropsychological impairment were more common in Ss who were HIV-positive, particularly those classified as Group IV, there were no systematic relationships between depression and neuropsychological impairment. Depressed mood and cognitive disturbance each seem to have unique associations to HIV illness status. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
98.
Lutgendorf Susan K.; Russell Daniel; Ullrich Philip; Harris Tamara B.; Wallace Robert 《Canadian Metallurgical Quarterly》2004,23(5):465
This study prospectively examined the relationship between religious attendance, interleukin-6 (IL-6) levels, and mortality rates in a community-based sample of 557 older adults. Attending religious services more than once weekly was a significant predictor of lower subsequent 12-year mortality and elevated IL-6 levels (> 3.19 pg/mL), with a mortality ratio of .32 (95% confidence interval [CI] = 0.15,0.72; p 相似文献
99.
Barbara K. Reck Robert B. Gordon 《JOM Journal of the Minerals, Metals and Materials Society》2008,60(7):55-59
Nickel and chromium are essential ingredients in alloys increasingly important for energy-efficient, environmentally friendly
modern technology. Quantitative assessment of the flows of these metals through the world economy from resource extraction
to final disposal informs resource policy, energy planning, environmental science, and waste management. This article summarizes
the worldwide technological cycles of nickel and chromium in 2000. Stainless steel is the major use of these metals, but they
serve numerous other special needs, as in superalloys for high-temperature service, as plating materials, and in coinage.
Because they are used primarily in alloys, novel recycling issues arise as their use becomes more widespread.
“... the great New York and St. Louis double track, nickel plated railroad...”
— Norwalk, Ohio, Chronicle 10 March 1881 announces arrival of surveyors for the future Nickel Plate Railway
“Later [1911] I formed an alloy of Iron and Chromium, which showed remarkable resistance to rust and tarnish ... [It was]
rediscovered by an Englishman named Brearley, in 1914.”
—Elwood Haynes to Stephen F. Roberts, 17 January 1925 相似文献
100.
Stirman Shannon Wiltsey; DeRubeis Robert J.; Crits-Christoph Paul; Brody Pamela E. 《Canadian Metallurgical Quarterly》2003,71(6):963
To determine the extent to which published randomized controlled trials (RCTs) of psychotherapy can be generalized to a sample of community outpatients, the authors used a method of matching information obtained from outpatient charts to inclusion and exclusion criteria from published RCT studies. They found that 80% of the patients in their sample who had diagnoses represented in the RCT literature were judged eligible for at least 1 published RCT; however, 58% of the patients had primary diagnoses such as adjustment disorder or dysthymia, which were not represented in the existing psychotherapy outcome literature. The most common reasons that patients in their sample did not match with published RCTs for psychotherapy are listed, and the implications of these findings for research and practice are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献