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81.
Clment Veys Abderrahim Benmoussa Romain Contentin Amandine Duchemin Emilie Brotin Jrme E. Lafont Yannick Saintigny Laurent Poulain Christophe Denoyelle Magali Demoor Florence Legendre Philippe Galra 《International journal of molecular sciences》2021,22(11)
Chondrosarcomas are malignant bone tumors. Their abundant cartilage-like extracellular matrix and their hypoxic microenvironment contribute to their resistance to chemotherapy and radiotherapy, and no effective therapy is currently available. MicroRNAs (miRNAs) may be an interesting alternative in the development of therapeutic options. Here, for the first time in chondrosarcoma cells, we carried out high-throughput functional screening using impedancemetry, and identified five miRNAs with potential antiproliferative or chemosensitive effects on SW1353 chondrosarcoma cells. The cytotoxic effects of miR-342-5p and miR-491-5p were confirmed on three chondrosarcoma cell lines, using functional validation under normoxia and hypoxia. Both miRNAs induced apoptosis and miR-342-5p also induced autophagy. Western blots and luciferase reporter assays identified for the first time Bcl-2 as a direct target of miR-342-5p, and also Bcl-xL as a direct target of both miR-342-5p and miR-491-5p in chondrosarcoma cells. MiR-491-5p also inhibited EGFR expression. Finally, only miR-342-5p induced cell death on a relevant 3D chondrosarcoma organoid model under hypoxia that mimics the in vivo microenvironment. Altogether, our results revealed the tumor suppressive activity of miR-342-5p, and to a lesser extent of miR-491-5p, on chondrosarcoma lines. Through this study, we also confirmed the potential of Bcl-2 family members as therapeutic targets in chondrosarcomas. 相似文献
82.
Jean‐Noël Jaubert Romain Privat Fabrice Mutelet 《American Institute of Chemical Engineers》2010,56(12):3225-3235
The PPR78 approach is a group contribution‐based thermodynamic model which combines at constant packing fraction the Peng–Robinson equation of state and a Van Laar‐type gE model. This article demonstrates that, using classical mixing rules (linear on b and quadratic on a), the PPR78 model may also be seen as a group contribution method for the estimation of the temperature‐dependent kij of the widely used PR EoS. Our model is endowed of 15 groups and it is possible to predict the kij for any mixture containing alkanes, aromatics, naphthenes, CO2, N2, H2S, and mercaptans. This study exhibits the capability of this approach to predict the phase behavior of synthetic petroleum fluids containing components of different volatilities. The many comparisons between calculated and experimental data on natural gases, crude oils, and gas condensates allow concluding that the PPR78 approach is a successful model for phase equilibria calculations of this kind of mixtures. © 2010 American Institute of Chemical Engineers AIChE J, 2010 相似文献
83.
Benjamin Le Droumaguet Romain LacombeHaï-Bang Ly Mohamed GuerrouacheBenjamin Carbonnier Daniel Grande 《Polymer》2014
Functional doubly porous polymeric materials based on cross-linked poly(2-hydroxyethyl methacrylate) (PHEMA) were engineered via novel porogen templating methodologies. Two straightforward and versatile strategies were implemented through the use of either CaCO3 microparticles or poly(methyl methacrylate) beads as macroporogens, in conjunction with either hydroxyapatite nanoparticles of around 200 nm average diameter or a porogenic solvent (e.g., ethanol) as nanoporogens. Upon porogen removal, macropores with dimensions in the 100 μm range were generated, while the second porosity lied within the 1 μm order of magnitude, as evidenced by mercury intrusion porosimetry and scanning electron microscopy. The possibility to further functionalize such biporous PHEMA-based frameworks was investigated through a two-step synthetic approach involving an activation stage, followed by the coupling of propargylamine as a model compound. The success of the functionalization procedure was clearly demonstrated by Raman spectroscopy that indicated the occurrence of alkyne functionality within the biporous materials. 相似文献
84.
Pattern Analysis and Applications - Histogram analysis has nowadays gain in interest, and a lot of work yet address this task. In most of the existing approaches, histograms are manipulated as... 相似文献
85.
We consider a general class of nonlinear reduced-order observers and show that the global asymptotic convergence of the observation error in the absence of network-induced constraints is maintained for the emulated observer semiglobally and practically (with respect to the maximum allowable transmission interval) when system measurements are sent through a communication channel. Networks governed by a Lyapunov uniformly globally asymptotically stable protocol are investigated. Our results can be used to synthesize various observers for networked control systems for a range of network configurations, as we illustrate it by considering classes of immersion and invariance observers which include the circle-criterion observers. 相似文献
86.
Code completion is a widely used productivity tool. It takes away the burden of remembering and typing the exact names of
methods or classes: As a developer starts typing a name, it provides a progressively refined list of candidates matching the
name. However, the candidate list usually comes in alphabetic order, i.e., the environment is only second-guessing the name
based on pattern matching, relying on human intervention to pick the correct one. Finding the correct candidate can thus be
cumbersome or slower than typing the full name. 相似文献
87.
To optimize the press filters commonly used to dewater residual sludge, the impact of the operating parameters must be better understood. The objectives of this article are (1) to identify the impact of the operating parameters on press filter performances and (2) to classify the operating parameters regarding their impact on dewatering performances. Experiments were performed with conditioned activated sludge in a tangential filtration cell, and a sensitivity analysis of the process was performed. This study emphasizes that cake thickness and filtration pressure have the most significant impacts on dewatering efficiency. These results suggest a promising outlook for press-filter optimization. 相似文献
88.
In this study, retention experiments were performed to characterize the variable sieving properties of a poly(dimethylsiloxane) (PDMS) membrane in relation with operating parameters. The swelling, transmembrane pressure, and temperature are all known to impact the physicochemical properties and morphology of PDMS polymer and were therefore varied for the purposes of our retention experiments which assessed them with the homologous series of polyethylene glycols (PEGs; 200–1500 g mol?1). The objectives were twofold—first, to evaluate the capacity to induce a targeted molecular weight cutoff (MWCO) by selecting appropriate filtration conditions and second to better understand the mechanisms involved during solvent‐resistant nanofiltration with PDMS. The selected solvents or solvent/solvent mixtures used throughout this study were found to induce swelling ratios of 1.16 (ethanol/ethyl acetate: 25/75), 1.26 (ethyl acetate), 1.33 (ethyl acetate/toluene: 50/50), and 1.41 (toluene), respectively. Linear correlations were obtained between the MWCO and the swelling ratio induced by each solvent and between the MWCO and the transmembrane pressure. Pore size calculations using solvent flux and retention data confirmed the variable sieving properties of the PDMS membrane in relation to the solvent‐induced swelling and applied transmembrane pressure. In addition, the study of the solute‐transfer rate through several operating conditions showed that both diffusive and convective transports occurred for the PEG solutes and that their respective contributions appeared dependent on the variable pore size of the PDMS membrane. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 41171. 相似文献
89.
IDDQ testing detects a majority of faults occurring in logic,ICs. Nethertheless, it has not eliminated the complex task of fault isolation at the silicon level of ICs.Liquid Crystak or Emission Microscopy can deal with this challenge. Unfortunately these two techniques lack sensitivity for some defects when the abnormal current consumption (IDDQ) remains weak.On the other hand we can use very powerful tools like the electron beam tester to deeply analyze faulty devices by internal contactless testing. In some laboratories, people have underlined the interest of merging the two techniques (IDDQ testing and Voltage Contrast) to get fast and accurate defect localization. In this paper, we will move on to the next step of identifying practical key issues necessary for obtaining results on current VLSI. 相似文献
90.
Gentle manipulation of micrometer-sized dielectric objects with optical forces has found many applications in both life and physical sciences. To further extend optical trapping toward the true nanometer scale, we present an original approach combining self-induced back action (SIBA) trapping with the latest advances in nanoscale plasmon engineering. The designed resonant trap, formed by a rectangular plasmonic nanopore, is successfully tested on 22 nm polystyrene beads, showing both single- and double-bead trapping events. The mechanism responsible for the higher stability of the double-bead trapping is discussed, in light of the statistical analysis of the experimental data and numerical calculations. Furthermore, we propose a figure of merit that we use to quantify the achieved trapping efficiency and compare it to prior optical nanotweezers. Our approach may open new routes toward ultra-accurate immobilization and arrangement of nanoscale objects, such as biomolecules. 相似文献