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11.
M Argenziano DA Dean N Moazami DJ Goldstein EA Rose HM Spotnitz D Burkhoff MC Oz ML Dickstein 《Canadian Metallurgical Quarterly》1998,115(3):700-708
BACKGROUND: Inhaled nitric oxide has been shown to be a potent and selective pulmonary vasodilator. Reports of increases in left ventricular end-diastolic pressure and episodes of pulmonary edema during the clinical use of inhaled nitric oxide in patients with preexisting left ventricular dysfunction have raised concerns that this agent may have myocardial depressant effects. We therefore undertook a study of the effects of inhaled nitric oxide on myocardial contractility in a porcine model of ventricular failure and pulmonary hypertension. METHODS: After inducing heart failure in 10 pigs by rapid ventricular pacing, hemodynamic measurements and pressure-volume diagrams (by the conductance method) were obtained in six animals at baseline and during administration of inhaled nitric oxide at concentrations of 20 and 40 ppm. Myocardial contractile state was assessed by the end-systolic pressure-volume relationship and preload-recruitable stroke work, whereas diastolic function was measured in terms of the end-diastolic pressure-volume relationship and the pressure decay time constant T. RESULTS: Baseline hemodynamics reflected heart failure and pulmonary hypertension, and inhaled nitric oxide induced significant reductions in mean pulmonary artery pressure and pulmonary vascular resistance. Although left ventricular end-diastolic pressure increased during administration of inhaled nitric oxide, no changes were observed in measures of systolic or diastolic function. CONCLUSIONS: Inhaled nitric oxide reduced pulmonary vascular resistance but did not alter myocardial contractility or diastolic function. Increases in left ventricular end-diastolic pressure during inhaled nitric oxide therapy are therefore not due to myocardial depression and may be related to increases in volume delivery to the left side of the heart resulting from reduced pulmonary vascular resistance. 相似文献
12.
PK Henke TM Bergamini SM Rose JD Richardson 《Canadian Metallurgical Quarterly》1998,64(1):39-45; discussion 45-6
Debate continues over which procedure is the best treatment for prosthetic graft infections. We retrospectively reviewed the medical records at our institution for all vascular graft infections that occurred from 1985 to 1995 to evaluate their occurrence, treatment, and outcome. Twenty-four patients had prosthetic graft infections. The average patient age was 62 years, and 67 per cent of the patients studied were men. The initial operation was for treatment of occlusive disease in 92 per cent of the patients, and aortofemoral bypasses were the most common procedures performed (15 of 24 patients, 63%). The average interval from graft implantation to presentation of infection was 29 months. In lower-extremity bypasses, the site of infection was most commonly in the groin (87%). Gram-positive organisms, including coagulase-negative Staphylococcus (32%) and Staphylococcus aureus (28%), were the most frequently isolated bacteria. Thirty procedures were performed for management of the graft infections. Extra-anatomic bypass was associated with no recurrent graft infections. Graft preservation was successful in two cases of early S. aureus infection (less than 1 year after original procedure), and in situ graft replacement was successful in all four cases of late-appearing coagulase-negative Staphylococcus infection (more than 1 year after original procedure). Both treatments failed in all five cases of Gram-negative infection (P = 0.008 by Fisher's exact test). The overall mortality and amputation rates were 17 per cent and 21 per cent, respectively, without significant differences between the treatment modalities. Extra-anatomic bypass remains the best treatment for prosthetic graft infection. In situ replacement and graft preservation treatments should be selective and based on presentation of the infection and the type of pathogenic organism. 相似文献
13.
Milton E. Rose 《Journal of scientific computing》1990,5(2):169-185
A compact finite-difference scheme to solve one-phase Stefan problems in one dimension is described. Numerical experiments indicate that the moving interface is obtained withO(t) accuracy when 3–4 iterations per time step are used to solve the nonlinear implicit scheme. The scheme can be adapted to ADI methods in higher dimensions. 相似文献
14.
Rose Challenger Desmond J. Leach Christopher B. Stride Chris W. Clegg 《人机工程学与制造业中的人性因素》2012,22(3):197-212
Clegg and Spencer's (2007) model of job design synthesizes and extends recent conceptions of the job design process by incorporating variables such as knowledge, motivation, and trust into a cyclical and dynamic system. The objective of this study was to examine the sequential organization of variables that comprise the model, as a basis from which to justify further investigations of the model's dynamic properties. Data were collected via questionnaires from 432 participants in two work organizations. Results obtained from structural equation modeling are broadly supportive of the proposed relationships between the variables. Implications of this initial study for future research and practice are discussed. © 2011 Wiley Periodicals, Inc. 相似文献
15.
Abouelnaga Amal M. Meaz Talaat M. Othman Abdelmageed M. Ghazy Riyad A. El Nahrawy Amany M. 《SILICON》2021,13(3):623-631
Silicon - The nature of the opening silicate- based surface affects the chemical interaction, spectroscopic and antimicrobial efficiency. The aim of this approach was to evaluate the spectroscopic... 相似文献
16.
El Nahrawy Amany M. Hemdan Bahaa A. Abou Hammad Ali B. Othman Abdelmageed M. Abouelnaga Amal M. Mansour A. M. 《SILICON》2021,13(9):2979-2991
Silicon - Magnesium calcium silicate nanostructures (MCSNS) loaded with (0.0, 0.6, 0.9, and 1.2 wt%) of Cephradine-drug consisting of mesoporous particles were functionally prepared by sol-gel... 相似文献
17.
Fish oils containing different levels of polymers of triacylglycerols formed during autoxidation were incubated with pancreatic
lipase to establish whether these polymers are substrates for lipase hydrolysis. With oils containing low amounts (less than
4%) of triacylglycerol polymers as substrates, both triacylglycerols and polymers of triacylglycerols were almost completely
hydrolyzed, and fatty acid monomers and monoacylglycerols were the major lipid products. Under the same incubation conditions,
some triacylglycerols remained intact when highly oxidized oils containing 20 or 30% triacylglycerol polymers were the substrate.
The fatty acid composition of these residual triacylglycerols was almost identical to that of triacylglycerols present at
the start of the assay. When fish oil containing 30% triacylglycerol polymers was incubated with the lipase, the component
triacylglycerols and polymers of triacylglycerols were hydrolyzed at similar rates, and fatty acid dimers were detected as
a product. It is concluded that the high molecular weight polymers of triacylglycerols present in oxidized fish oils can be
hydrolyzed by pancreatic lipasein vitro. 相似文献
18.
The objective of this study was to identify how physiological measures relate to self-reported vehicle seating discomfort. Twelve subjects of varied anthropometric characteristics were enrolled in the study. Subjects sat in two seats over a 2-h period and were evaluated via three physiological measures (near-infrared spectroscopy, electromyography and pressure mapping) yielding six testing sessions. Subjective discomfort surveys were recorded before and after each session for nine regions of the body. Conditional classification discomfort models were developed through dichotomised physiological responses and anthropometry to predict subjective discomfort in specific body locations. Models revealed that subjects taller than 171 cm with reduced blood oxygenation in the biceps femoris or constant, low-level muscle activity in the trapezius tended to report discomfort in the lower extremities or neck, respectively. Subjects weighing less than 58 kg with reduced blood oxygenation in the biceps femoris or unevenly distributed pressure patterns tended to report discomfort in the buttocks. The sensitivities and specificities of cross-validated models ranged between 0.69 and 1.00. 相似文献
19.
Philip V. Yaneff Karlis Adamsons Rose A. Ryntz Dottie Britz 《Journal of Coatings Technology》2002,74(933):135-141
Flexible automotive coatings are susceptible to scratch and mar damage, especially during finishing and assembly operations.
One-component (1K) flexible clearcoats exhibit very good scratch and mar resistance, but unfortunately suffer from poor durability
and environmental etch resistance. Two-component clearcoats offer improvements in both etch and durability, but at the expense
of scratch and mar. In this paper, the concept and properties of 1K flexibilized silane clearcoats for use on automotive plastics
will be introduced and their structure/property relationships examined as they apply to scratch and mar.
The role of coating crosslink density, toughness, glass transition temperature (Tg), and surface profile on the scratch damage of coated plastic substrates will be described. In addition, a new scratch methodology,
termed Scratcho, is utilized to determine relative scratch performance and is compared to conventional scratch resistance
testing. Results to date indicate that hardness, as affected by the glass transition temperature, and crosslink density, as
it contributes to higher essential work values, both affect resultant scratch propensity of the flexible coatings. The relative
ranking of different coating systems employing alternate crosslinkers (e.g., isocyanate and melamine) is also presented and
compared to the newly developed silane crosslinked coatings.
Presented at the 28th International Waterborne, High-Soids, and Powder Coatings Symposium, Feb. 21–23, 2001, in New Orleans.
LA.
377 Fairall St., Ajax, Ont., L1S 1R7, Canada.
401 Southfield Rd., P.O. Box 6231, Dearborn, MI 48121-6231. 相似文献
20.
The tensile behavior of polycarbonate was studied at large strains below the glass‐transition temperature. Experiments were carried out at a series of constant temperatures and also under conditions of falling temperatures. The specimens necked with a natural draw ratio of approximately 2, and the study was mainly focused on the necked material. Isothermal experiments revealed an elastic mechanism that initiated beyond the natural draw ratio. A model consisting of an Eyring process and two Gaussian elastic mechanisms was found to be applicable to both the isothermal and anisothermal stress‐relaxation and stress–strain results. The same model also produced reasonable estimates of the stresses generated during the necking process. In addition, a simple relationship between the isothermal and anisothermal stress relaxation was demonstrated. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 96: 2105–2116, 2005 相似文献