Macrophage Membrane-Coated Nanoparticles Sensitize Glioblastoma to Radiation by Suppressing Proneural–Mesenchymal Transformation in Glioma Stem Cells

Radiotherapy is identified as a crucial treatment for patients with glioblastoma, but recurrence is inevitable. The efficacy of radiotherapy is severely hampered partially due to the tumor evolution. Growing evidence suggests that proneural glioma stem cells can acquire mesenchymal features coupled with increased radioresistance. Thus, a better understanding of mechanisms underlying tumor subclonal evolution may develop new strategies. Herein, data highlighting a positive correlation between the accumulation of macrophage in the glioblastoma microenvironment after irradiation and mesenchymal transdifferentiation in glioblastoma are presented. Mechanistically, elevated production of inflammatory cytokines released by macrophages promotes mesenchymal transition in an NF-κB-dependent manner. Hence, rationally designed macrophage membrane-coated porous mesoporous silica nanoparticles (MMNs) in which therapeutic anti-NF-κB peptides are loaded for enhancing radiotherapy of glioblastoma are constructed. The combination of MMNs and fractionated irradiation results in the blockage of tumor evolution and therapy resistance in glioblastoma-bearing mice. Intriguingly, the macrophage invasion across the blood-brain barrier is inhibited competitively by MMNs, suggesting that these nanoparticles can fundamentally halt the evolution of radioresistant clones. Taken together, the biomimetic MMNs represent a promising strategy that prevents mesenchymal transition and improves therapeutic response to irradiation as well as overall survival in patients with glioblastoma.     

Stabilization of uncertain networked control systems with actuator saturation and probabilistic cyberattacks

This paper investigates the stabilization of uncertain networked control systems (NCSs) with actuator saturation and cyberattacks. The cyberattacks are governed by a set of independent random variables satisfying Bernoulli distribution. To relieve the network bandwidth load effectively, an event-triggered communication strategy is proposed. By employing Lyapunov stability theory and stochastic analysis techniques, a stability criterion is obtained for the system with actuator saturation and cyberattacks. Moreover, the desired controller gain is derived by solving some matrix inequalities. Finally, the validity and applicability of the criteria are verified through numerical examples.     

小河嘴水电站增效扩容改造电气设备分析

小河嘴水电站已运行四十多年,设备老化,故障多,自动化水平低,对该站进行增效扩容改造是必要的,而且也是可行的。     

Graphene oxide-decorated Fe<Subscript>2</Subscript>(MoO<Subscript>4</Subscript>)<Subscript>3</Subscript> microflowers as a promising anode for lithium and sodium storage

Mixed transition metal oxides (MTMOs) have received intensive attention as promising anode materials for lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs). In this work, we demonstrate a facile one-step water-bath method for the preparation of graphene oxide (GO) decorated Fe₂(MoO₄)₃ (FMO) microflower composite (FMO/GO), in which the FMO is constructed by numerous nanosheets. The resulting FMO/GO exhibits excellent electrochemical performances in both LIBs and SIBs. As the anode material for LIBs, the FMO/GO delivers a high capacity of 1,220 mAh·g^–1 at 200 mA·g^–1 after 50 cycles and a capacity of 685 mAh·g^–1 at a high current density of 10 A·g^–1. As the anode material for SIBs, the FMO/GO shows an initial discharge capacity of 571 mAh·g^–1 at 100 mA·g^–1, maintaining a discharge capacity of 307 mAh·g^–1 after 100 cycles. The promising performance is attributed to the good electrical transport from the intimate contact between FMO and graphene oxide. This work indicates that the FMO/GO composite is a promising anode for high-performance lithium and sodium storage.

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卷积积分和拉普拉斯变换在一阶电路中的应用

电路的任意激励的零状态响应,可以用卷积积分和拉普拉斯交换的方法求解。本文通过两个一阶电路的实例,阐述了两种方法的应用特点。     

Evaluation of Landsat 8 OLI imagery for unsupervised inland water extraction

The successful launch of the Landsat 8 satellite continues the Earth observation of the Landsat series, which has been taking place for nearly 40 years. With the increase in the band number and the improved spectral range compared with the previous Landsat imagery, it will be possible to expand the application of the new Landsat 8 imagery. The purpose of this study is to explore water extraction based on the new Landsat 8 Operational Land Imager (OLI) imagery. According to the specific inland water conditions (clear water, turbid water, and eutrophic water), a number of highly adaptable water indices are assessed for water extraction using Landsat OLI imagery. The results show that clear water is the easiest to extract among the different types of waterbodies, with the highest average accuracy of 97%. The highest-accuracy methods are the automated water extraction index for shadow pixels (AWEI_sh), the normalized difference water index using bands 4 and 7 (NDWI₄₇), and the normalized difference water index using bands 3 and 7 (NDWI₃₇), with accuracies of 98.55%, 95.50%, and 96.61%, corresponding to clear water, turbid water, and eutrophic water, respectively. Through the analysis of the different methods for optimal band selection, the seventh band OLI7 (shortwave infrared 2, SWIR-2) of Landsat OLI shows the best performance in water identification. When applying the water indices to water extraction, Otsu’s algorithm has been used to automatically select the water threshold. Using extensive experiments with Otsu’s algorithm and a manual method, it was found that Otsu’s algorithm can replace manual selection and has the ability to select an accurate threshold for water extraction.     

Reversible data hiding in encrypted images based on multi-level encryption and block histogram modification

Multimedia Tools and Applications - In recent years there has been significant interest in reversible data hiding, and also in particular, reversible data hiding in encrypted images (RDH-EI). This...     

基于工作任务的“4-5-6”情景化项目驱动教学模式的设计与实践

目前我国高职教育正处于改革的重要阶段,创新课程的教学模式,是高职教育的要求,也是课程建设与职业岗位有效接轨的要求。基于工作任务的"4-5-6"情景化项目驱动教学模式,是以职业能力培养为目标,围绕"岗位工作任务"这一主题,以"4"个阶段来划分能力培养过程,以"5"化教学作为教学设计,以"6"个步骤作为教学实施的教学法。通过在Linux操作系统课程教学中的改革实践表明,该教学模式培养了学生的自我学习能力和创造力,提高了学生的职业能力。