Doomed program points

Any programming error that can be revealed before compiling a program saves precious time for the programmer. While integrated development environments already do a good job by detecting, e.g., data-flow abnormalities, current static analysis tools suffer from false positives (“noise”) or require strong user interaction. We propose to avoid this deficiency by defining a new class of errors. A program fragment is doomed if its execution will inevitably fail, regardless of which state it is started in. We use a formal verification method to identify such errors fully automatically and, most significantly, without producing noise. We report on experiments with a prototype tool.     

Specification and verification challenges for sequential object-oriented programs

The state of knowledge in how to specify sequential programs in object-oriented languages such as Java and C# and the state of the art in automated verification tools for such programs have made measurable progress in the last several years. This paper describes several remaining challenges and approaches to their solution.     

Thunderbolt [railguns]

The Thunderbolt program facility will provide 60 MJ of energy at 21 kV from capacitor banks for powering breech-fed or distributed energy railgun electromagnetic launchers. After discharge from the capacitor banks, the energy pulse is shaped with room-temperature solenoidal inductors, with switching being provided by D and E-sized ignitrons. Fast recharging of the capacitor banks could permit repetitive operation. A screened room provides protection for the control and data acquisition equipment, while a single-point ground scheme protects against ground loops. A substantial foundation provides support for the catch tank, while high-vacuum equipment will permit operation at high velocities with the round-bore railgun. Preinjection of the test projectiles to velocities of about 1 km/s is provided by a helium gas gun to minimize damage to the breech section of the railgun. In addition to providing details on Thunderbolt, operating experience and results obtained with a subscale launcher are described     

SDIO pulsed power R&D requirements

The Strategic Defense Initiative Organization (SDIO) performs pulse power research and technology base development to satisfy the requirements of six major systems. These systems-neutral particle beams (NPBs), space-based free electron lasers (SBFELs), ground-based lasers (GBLs), electromagnetic launchers (EMLs), laser radars (LRs), and high-power microwaves (HPMs)-are described. The research is focused on component development with mass, volume, and efficiency being the key technology drivers. Order-of-magnitude improvements are in many cases required. These development efforts include those power conditioning devices and components needed to match the electrical characteristics of the power source with those required by the load. Technology areas include energy storage, switching, and power conversion. The specific component requirements and two space experiments integrating developmental components are described     

Finding stale‐value errors in concurrent programs

Concurrent programs can suffer from many types of errors, not just the well‐studied problems of deadlocks and simple race conditions on variables. This paper addresses a kind of race condition that arises from reading a variable whose value is possibly out of date. The paper introduces a simple technique for detecting such stale values, and reports on the encouraging experience with a compile‐time checker that uses the technique. Copyright © 2004 John Wiley & Sons, Ltd.     

A method for showing progress

Charmed by the ease with which [vdS95] shows that its program makes progress, I state a theorem that allows for showing progress of a UNITY-like program in an easy way. I also give a proof of that theorem.     

Efficient weakest preconditions

Desired computer-program properties can be described by logical formulas called verification conditions. Different mathematically-equivalent forms of these verification conditions can have a great impact on the performance of an automatic theorem prover that tries to discharge them. This paper presents a simple weakest-precondition understanding of the ESC/Java technique for generating verification conditions. This new understanding of the technique spotlights the program property that makes the technique work.     

The hypotriglyceridemic effect of dietary n−3 FA is associated with increased β-oxidation and reduced leptin expression

To study the mechanisms responsible for the hypotriglyceridemic effect of marine oils, we monitored the effects of high dietary intake of n-3 PUFA on hepatic and muscular beta-oxidation, plasma leptin concentration, leptin receptor gene expression, and in vivo insulin action. Two groups of male Wistar rats were fed either a high-fat diet [28% (w/w) of saturated fat] or a high-fat diet containing 10% n-3 PUFA and 18% saturated fat for 3 wk. The hypotriglyceridemic effect of n-3 PUFA was accompanied by increased hepatic oxidation of palmitoyl-CoA (125%, P < 0.005) and palmitoyl-L-carnitine (480%, P < 0.005). These findings were corroborated by raised carnitine palmitoyltransferase-2 activity (154%, P < 0.001) and mRNA levels (91%, P < 0.01) as well as by simultaneous elevation of hepatic peroxisomal acyl-CoA oxidase activity (144%, P < 0.01) and mRNA content (82%, P < 0.05). In contrast, hepatic carnitine palmitoyltransferase-1 activity remained unchanged despite a twofold increased mRNA level after n-3 PUFA feeding. Skeletal muscle FA oxidation was less affected by dietary n-3 PUFA, and the stimulatory effect was found only in peroxisomes. Dietary intake of n-3 PUFA was followed by increased acyl-CoA oxidase activity (48%, P < 0.05) and mRNA level (83%, P < 0.05) in skeletal muscle. The increased FA oxidation after n-3 PUFA supplementation of the high-fat diet was accompanied by lower plasma leptin concentration (-38%, P < 0.05) and leptin mRNA expression (-66%, P < 0.05) in retroperitoneal adipose tissue, and elevated hepatic mRNA level for the leptin receptor Ob-Ra (140%, P < 0.05). Supplementation of the high-fat diet with n-3 PUFA enhanced in vivo insulin sensitivity, as shown by normalization of the glucose infusion rate during euglycemic hyperinsulinemic clamp. Our results indicate that the hypotriglyceridemic effect of dietary n-3 PUFA is associated with stimulation of FA oxidation in the liver and to a smaller extent in skeletal muscle. This may ameliorate dyslipidemia, tissue lipid accumulation, and insulin action, in spite of decreased plasma leptin level and leptin mRNA in adipose tissue.     

Dose-Dependent Effects of Docosahexaenoic Acid Supplementation on Blood Lipids in Statin-Treated Hyperlipidaemic Subjects

The objective of the study was to evaluate potential benefits of docosahexaenoic acid (DHA) rich fish oil supplementation as an adjunct to statin therapy for hyperlipidaemia. A total of 45 hyperlipidaemic patients on stable statin therapy with persistent elevation of plasma triglycerides (averaging 2.2 mmol/L) were randomised to take 4 g/day (n = 15) or 8 g/day (n = 15) of tuna oil or olive oil (placebo, n = 15) for 6 months. Plasma lipids, blood pressure and arterial compliance were assessed initially and after 3 and 6 months in 40 subjects who completed the trial. Plasma triglycerides were reduced 27% by 8 g/day DHA-rich fish oil (P < 0.05) but not by 4 g/day when compared with the placebo and this reduction was achieved by 3 months and was sustained at 6 months. Even though total cholesterol was already well controlled by the statin treatment (mean initial level 4.5 mmol/L), there was a further dose-dependent reduction with fish oil supplementation (r = −0.344, P < 0.05). The extent of total cholesterol reduction correlated (r = −0.44) with the initial total cholesterol levels (P < 0.005). In the subset with initial plasma cholesterol above 3.8 mmol/L, plasma very low density lipoprotein (VLDL), intermediate-density lipoprotein (IDL) and low-density lipoprotein (LDL) were isolated and assayed for cholesterol and apolipoprotein B (apoB) at the commencement of the trial and at 3 months of intervention. Fish oil tended to lower cholesterol and apoB in VLDL and raise both in LDL. There were no changes in IDL cholesterol, IDL apoB and high-density lipoprotein cholesterol. The results demonstrate that DHA-rich fish oil supplementation (2.16 g DHA/day) can improve plasma lipids in a dose-dependent manner in patients taking statins and these changes were achieved by 3 months. Fish oil in addition to statin therapy may be preferable to drug combinations for the treatment of combined hyperlipidaemia.