A Synthetic Overview of Benzoxazines and Benzoxazepines as Anticancer Agents

Benzoxazines and benzoxazepines are nitrogen and oxygen-containing six and seven-membered benzo-fused heterocyclic scaffolds, respectively. Benzoxazepines and benzoxazines are well-known pharmacophores in pharmaceutical chemistry, which are of significant interest and have been extensively studied because of their promising activity against various diseases including their wide range of anticancer activity. Several reports are known for synthesizing benzoxazine and benzoxazepine-based compounds in the literature. Herein this review provides a critical analysis of synthetic strategies towards benzoxazines and benzoxazepines along with various ranges of anticancer activities based on these molecules that have been reported from 2010 onwards. This review also focuses on the structure-activity relationship of the benzoxazine and benzoxazepine scaffolds containing bioactive compounds and describes how the structural modification affects their anticancer activity.     

Isotope Engineered Fluorinated Single and Bilayer Graphene: Insights into Fluorination Selectivity,Stability, and Defect Passivation

Tailoring the physicochemical properties of graphene through functionalization remains a major interest for next-generation technological applications. However, defect formation due to functionalization greatly endangers the intrinsic properties of graphene, which remains a serious concern. Despite numerous attempts to address this issue, a comprehensive analysis has not been conducted. This work reports a two-step fluorination process to stabilize the fluorinated graphene and obtain control over the fluorination-induced defects in graphene layers. The structural, electronic and isotope-mass-sensitive spectroscopic characterization unveils several not-yet-resolved facts, such as fluorination sites and C F bond stability in partially-fluorinated graphene (F-SLG). The stability of fluorine has been correlated to fluorine co-shared between two graphene layers in fluorinated-bilayer-graphene (F-BLG). The desorption energy of co-shared fluorine is an order of magnitude higher than the C F bond energy in F-SLG due to the electrostatic interaction and the inhibition of defluorination in the F-BLG. Additionally, F-BLG exhibits enhanced light–matter interaction, which has been utilized to design a proof-of-concept field-effect phototransistor that produces high photocurrent response at a time <200 µs. Thus, the study paves a new avenue for the in-depth understanding and practical utilization of fluorinated graphenic carbon.     

Usability of a telehealth solution based on TV interaction for the elderly: the VITASENIOR-MT case study

Universal Access in the Information Society - Remote monitoring of biometric data in the elderly population is an important asset for improving the quality of life and level of independence of...     

Free surface dynamics of MHD third-grade fluid model over a heated stretching sheet with variable fluid properties

A thorough investigation of MHD third-grade differential-type fluid flow over a heated stretching sheet is performed in this work. In particular, we analyze the film thinning process, when the thermal sensitive fluid parameters vary due to the effect of heat supplied to the stretching sheet. Starting with a two-dimensional (2D) free surface boundary value problem of non-Newtonian third-grade fluid, we present a systematic derivation of a 1D transient thin-film height equation using longwave analysis with respect to the small aspect ratio of the fluid domain. The derived model is used to study the impact of Newtonian and non-Newtonian parameters with variable fluid properties on the thin film height. The model is discretized using an upwind discretization in space and implicit time integration to guarantee first-order convergence. The model is analyzed thoroughly with the help of numeric computing software MATLAB. The existing findings for a Newtonian fluid are in excellent agreement with derived evidence. In comparison to Newtonian fluid, the study finds that the third-grade parameter causes thinning under different parametric restrictions. Simulations on the coupling effect explain that, the film thickness can be reduced with a high Marangoni number for highly viscous fluids. Also, since the effect of the conductivity parameter can be reduced at a low Prandtl number, the fluid shows a thinning effect. The film thinning rate, on the other hand, is reduced by the magnetic field.     

Secure access privilege delegation using attribute-based encryption

International Journal of Information Security - Attribute-based encryption (ABE) is widely used for a secure and efficient data sharing. The predetermined access policy of ABE shares the data with...     

Rapid Detection of Biomolecules in a Junction Less Tunnel Field-Effect Transistor (JL-TFET) Biosensor

Silicon - In this paper, we present a double gate JL-TFET based biosensor by varying the gate dielectric constant to detect various biomolecules through label-free detection technique. An...     

Knowledge-based system for three-way decision-making under uncertainty

Knowledge and Information Systems - Knowledge-based systems developed based on Dempster–Shafer theory and prospect theory enhances decision-making under uncertainty. But at times, the...     

Exhaust dyeing of meta-aramid yarn at low temperature and time

Exhaust dyeing of aramid fibre is difficult due to its high crystalline and compact structure. In this study aramid yarn is pre-treated with solvent dimethyl sulphoxide to facilitate the dyeing process and then dyeing is achieved with a cationic dye. Pre-treatment at high temperature leads to the reduction in tensile strength of yarn which is not desirable. Therefore, in this work pre-treatment has been carried out at different temperatures and time to standardise those parameters to enhance the dye uptake with minimum reduction in strength. Further, dyeing temperature and time has been standardised keeping the standard pre-treatment parameters fixed. From the study, pre-treatment temperature of 30°C for 10 min and dyeing temperature of 100°C for 30 min are found suitable for better colour strength without much compromising on strength of yarn. The fastness properties of untreated and treated dyed yarns were comparable.     

A Comprehensive Review on High Electron Mobility Transistor (HEMT) Based Biosensors: Recent Advances and Future Prospects and its Comparison with Si-Based Biosensor

Silicon - In this paper, we focus on recent advances of the high-electron-mobility transistor (HEMT)-based biosensors for the detection of various biomolecules. The vital utilization of biosensors...