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排序方式: 共有58条查询结果,搜索用时 78 毫秒
31.
The aldol addition is the classical method for the construction of carbon chains with oxygen functionality in 1,3-distance. Depending on whether an α-substituted or an α-unsubstituted enolate is allowed to react with an aldehyde, two or one stereogenic centers are created. A large number of stereoselective variants developed in recent years enable to obtain nonracemic β-hydroxy-carbonyl compounds. This article reports on aldol additions of carboxylic esters and thioesters which deliver nonracemic β-hydroxycarboxylic acids in a stereoselective manner. In this context, the report emphasizes on aldol additions with triphenylglycol derived acetates and propionates. 相似文献
32.
Zachary Freudenburg Khaterah Kohneshin Erik Aarnoutse Mariska Vansteensel Mariana Branco Sacha Leinders Max van den Boom Elmar G.M.Pels Nick Ramsey 《控制理论与技术(英文版)》2021,19(4):444-454
While brain computer interfaces(BCIs)offer the potential of allowing those suffering from loss of muscle control to once again fully engage with their environme... 相似文献
33.
Sandra Preuner Agnes Barna Florian Frommlet Stefan Czurda Byrgazov Konstantin Mary Alikian Katerina Machova Polakova Tomasz Sacha Johan Richter Thomas Lion Christian Gabriel 《International journal of molecular sciences》2016,17(5)
Identification and quantitative monitoring of mutant BCR-ABL1 subclones displaying resistance to tyrosine kinase inhibitors (TKIs) have become important tasks in patients with Ph-positive leukemias. Different technologies have been established for patient screening. Various next-generation sequencing (NGS) platforms facilitating sensitive detection and quantitative monitoring of mutations in the ABL1-kinase domain (KD) have been introduced recently, and are expected to become the preferred technology in the future. However, broad clinical implementation of NGS methods has been hampered by the limited accessibility at different centers and the current costs of analysis which may not be regarded as readily affordable for routine diagnostic monitoring. It is therefore of interest to determine whether NGS platforms can be adequately substituted by other methodological approaches. We have tested three different techniques including pyrosequencing, LD (ligation-dependent)-PCR and NGS in a series of peripheral blood specimens from chronic myeloid leukemia (CML) patients carrying single or multiple mutations in the BCR-ABL1 KD. The proliferation kinetics of mutant subclones in serial specimens obtained during the course of TKI-treatment revealed similar profiles via all technical approaches, but individual specimens showed statistically significant differences between NGS and the other methods tested. The observations indicate that different approaches to detection and quantification of mutant subclones may be applicable for the monitoring of clonal kinetics, but careful calibration of each method is required for accurate size assessment of mutant subclones at individual time points. 相似文献
34.
Anna Zimna Magdalena Kaczmarska Ewa Szczesny-Malysiak Aleksandra Wajda Katarzyna Bulat Fatih Celal Alcicek Malgorzata Zygmunt Tomasz Sacha Katarzyna Maria Marzec 《International journal of molecular sciences》2021,22(6)
Packed red blood cells (pRBCs), the most commonly transfused blood product, are exposed to environmental disruptions during storage in blood banks. In this study, temporal sequence of changes in the ion exchange in pRBCs was analyzed. Standard techniques commonly used in electrolyte measurements were implemented. The relationship between ion exchange and red blood cells (RBCs) morphology was assessed with use of atomic force microscopy with reference to morphological parameters. Variations observed in the Na+, K+, Cl−, H+, HCO3−, and lactate ions concentration show a complete picture of singly-charged ion changes in pRBCs during storage. Correlation between the rate of ion changes and blood group type, regarding the limitations of our research, suggested, that group 0 is the most sensitive to the time-dependent ionic changes. Additionally, the impact of irreversible changes in ion exchange on the RBCs membrane was observed in nanoscale. Results demonstrate that the level of ion leakage that leads to destructive alterations in biochemical and morphological properties of pRBCs depend on the storage timepoint. 相似文献
35.
Dual‐Mechanism Antimicrobial Polymer–ZnO Nanoparticle and Crystal Violet‐Encapsulated Silicone
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Sacha Noimark Jonathan Weiner Nuruzzaman Noor Elaine Allan Charlotte K. Williams Milo S. P. Shaffer Ivan P. Parkin 《Advanced functional materials》2015,25(9):1367-1373
The prevalence of healthcare‐associated infection caused by multidrug‐resistant bacteria is of critical concern worldwide. It is reported on the development of a bactericidal surface prepared by use of a simple, upscalable, two‐step dipping strategy to incorporate crystal violet and di(octyl)phosphinic‐ acid‐capped zinc oxide nanoparticles into medical grade silicone, as a strategy to reduce the risk of infection. The material is characterized by UV–vis absorbance spectroscopy, X‐ray photoelectron spectroscopy (XPS), inductively coupled plasma‐optical emission spectroscopy (ICP‐OES) and transmission electron microscopy (TEM) and confirmed the incorporation of the ZnO nanoparticles in the polymer. The novel system proves to be a highly versatile bactericidal material when tested against both Staphylococcus aureus and Escherichia coli, key causative micro‐organisms for hospital‐acquired infection (HAI). Potent antimicrobial activity is noted under dark conditions, with a significant enhancement exhibits when the surfaces are illuminated with a standard hospital light source. This polymer has the potential to decrease the risk of HAI, by killing bacteria in contact with the surface. 相似文献
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37.
Ni Yang Ian D. Fisk Robert Linforth Keith Brown Stuart Walsh Sacha Mooney Craig Sturrock Joanne Hort 《European Food Research and Technology》2012,235(6):1083-1091
The influence of flavour solvent, propylene glycol (PG) and triacetin (TA), was investigated on the micro-structure (as measured by X-ray micro-Computed Tomography, X-ray μCT) and aroma compound distribution (as measured by HPLC) within shortcake biscuits. X-ray μCT scanning showed biscuits made with PG had smaller pores and higher porosity than biscuits made with TA. Vanillin distribution across the biscuits was not homogeneous and was found at higher concentrations in the centre of the biscuits than the edge or bottom. The baked aroma compound 5-hydroxymethyl-furfural (HMF) was present at higher concentrations at the surface of the biscuits where Maillard chemistry is presumed to occur at its highest rate. The type of solvent had a significant effect on the total concentration and distribution of aroma compounds (p?<?0.05). TA biscuits retained greater vanillin and more HMF was formed during baking when compared to PG biscuits. The core of TA biscuits had (on a relative scale) a much greater vanillin and lower HMF concentration than PG biscuits when compared to their periphery. Although this may be due to different physicochemical properties of the two solvents and varying levels of interactions with other ingredients, the micro-structure differences indicated by X-ray μCT image analysis illustrate one potential route by which the flavour solvent may be influencing the generation and stability of biscuit aroma compounds. 相似文献
38.
A comparison of economy and sagittal plane trunk movements among back-, back/front- and head-loading
Sean Hudson Carlton Cooke Simeon Davies Sacha West Raeeq Gamieldien Chris Low 《Ergonomics》2018,61(9):1216-1222
It has been suggested that freedom of movement in the trunk could influence load carriage economy. This study aimed to compare the economy and sagittal plane trunk movements associated with three load carriage methods that constrain posture differently. Eighteen females walked at 3?km.h?1 with loads of 0, 3, 6, 9, 12, 15 and 20?kg carried on the back, back/front and head. Load carriage economy was assessed using the Extra Load Index (ELI). Change in sagittal plane trunk forward lean and trunk angle excursion from unloaded to loaded walking were assessed. Results show no difference in economy between methods (p?=?.483), despite differences in the change in trunk forward lean (p?=?.001) and trunk angle excursion (p?=?.021) from unloaded to loaded walking. We conclude that economy is not different among the three methods of load carriage, despite significant differences in sagittal plane trunk movements.Practitioner summary: This article shows, based on mean data, that there is no difference in economy among back, back/front and head-loading, despite differences in trunk movement. It is possible a combination of factors align to influence individual economy, rather than a single set of factors, applicable to all individuals for each method. 相似文献
39.
Because of the complicated structure of the built environment, it is frequently difficult to obtain good results on sustainable development projects. In The Netherlands, the Dutch government have used a range of new steering instruments which have cleverly enabled innovation to take place within a market economy. This imaginative governmental process uses covenants, network management and above all, demonstration projects to assess the feasibility of innovation. The authors describe the process and consider examples from energy efficient and sustainable housing, highlighting the importance of clear targets. 相似文献
40.
The user experience of current P2P Personal and Social networking systems does not meet the usability needs of the technically naïve users. This is the motivation behind MyNet, a P2P platform that enables non-expert users to easily organize their resources and share them in their immediate social neighborhood. In this paper, we present our experience following a user-centered approach in designing MyNet: using real-world metaphors in the core system, leveraging NFC-based touch to mirror human behavior models, and involving actual users in the design process. The results of our 50-user usability evaluation are also presented in detail. 相似文献