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排序方式: 共有391条查询结果,搜索用时 15 毫秒
21.
Sarbani Ghoshal Sandip Mukherjee Molee Chakraborty Eliwaza Naomi Msengi Jake Haubner Anutosh Chakraborty 《International journal of molecular sciences》2022,23(4)
(1) Background: We previously demonstrated that disruption of IP6K1 improves metabolism, protecting mice from high-fat diet-induced obesity, insulin resistance, and non-alcoholic fatty liver disease and steatohepatitis. Age-induced metabolic dysfunction is a major risk factor for metabolic diseases. The involvement of IP6K1 in this process is unknown. (2) Methods: Here, we compared body and fat mass, insulin sensitivity, energy expenditure and serum-, adipose tissue- and liver-metabolic parameters of chow-fed, aged, wild type (aWT) and whole body Ip6k1 knockout (aKO) mice. (3) Results: IP6K1 was upregulated in the adipose tissue and liver of aWT mice compared to young WT mice. Moreover, Ip6k1 deletion blocked age-induced increase in body- and fat-weight and insulin resistance in mice. aKO mice oxidized carbohydrates more efficiently. The knockouts displayed reduced levels of serum insulin, triglycerides, and non-esterified fatty acids. Ip6k1 deletion partly protected age-induced decline of the thermogenic uncoupling protein UCP1 in inguinal white adipose tissue. Targets inhibited by IP6K1 activity such as the insulin sensitivity- and energy expenditure-inducing protein kinases, protein kinase B (PKB/Akt) and AMP-activated protein kinase (AMPK), were activated in the adipose tissue and liver of aKO mice. (4) Conclusions: Ip6k1 deletion maintains healthy metabolism in aging and thus, targeting this kinase may delay the development of age-induced metabolic dysfunction. 相似文献
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Mingxuan Lu Prabhakar V. Gulgunje Pedro J. Arias-Monje Jeffrey Luo Jyotsna Ramachandran Yudhisthira Sahoo Sandip Agarwal Satish Kumar 《Polymer Engineering and Science》2020,60(9):2143-2151
Bi-component, polyacrylonitrile (PAN)/carbon nanotube (CNT) fibers were processed, at different core-sheath area ratios, by gel spinning. A percolated CNT network at 10 wt% CNT in the sheath enhanced electrical conductivity as compared to the neat PAN fiber, while PAN polymer in the core contributed to the good mechanical properties. Fibers with relatively thin sheath allowed overall CNT loading as low as 3.7 wt% to be made with good electrical conductivity, and PAN stabilization by Joule heating was demonstrated. Such fibers with combined good mechanical properties and electrical conductivity can also potentially be used for electrical heating of fabrics, for making smart textiles, and for electromagnetic interference shielding. 相似文献
24.
Anoop K. Mukhopadhyay Keshaw D. Joshi Arjun Dey Riya Chakraborty Ashok K. Mandal Amit Rav Jiten Ghosh Sandip Bysakh Sampad K. Biswas Satish C. Gupta 《Ceramics International》2011,37(7):2365-2376
Shock recovered samples of a coarse grain (10 μm), high density (>99.9% theoretical) alumina from asymmetric impact tests conducted at 6.5 GPa (e.g. 3.2 times its Hugoniot Elastic Limit) in a single stage gas gun and characterized by X-ray diffractometry, scanning and field emission scanning electron microscopy, and transmission electron microscopy showed prolific presence of reduced crystallite size, higher average microstrain, grain localized micro/nano-scale deformations, micro-cleavages, grain-boundary microcracks, micro-wing crack formation, extensive shear induced deformations and fractures localized at grains, grain boundaries and triple grain junctions, grain localized entanglement of dislocations and their pile up impeded at grain boundaries. A new qualitative model based on micro-shear and micro-twist induced deformation and fracture in single and/or multiple planes in suitably oriented grain and/or grain assembly was developed to explain the experimentally observed damage evolution process. 相似文献
25.
Sandip B. Bankar Mahesh V. Bule Rekha S. Singhal Laxmi Ananthanarayan 《Food and Bioprocess Technology》2009,2(4):344-352
A number of nutritional factors influencing glucose oxidase (EC 1.1.3.4) production by Aspergillus niger NCIM 545 were studied. The synthesis of glucose oxidase by A. niger was investigated in two steps using submerged fermentation at 30 ± 2 °C and 180 rpm for 96 h. Primarily, nutritional components
were selected by one-factor-at-a-time method, and the significance of each component with respect to glucose oxidase production
was identified by Plackett–Burman design (seven variables including six nutritional viz. sucrose, sodium nitrate, peptone,
calcium carbonate, magnesium sulfate, and potassium dihydrogen phosphate, and one dummy or unassigned variable were studied
with eight experiments). In the second step, concentration of most significant factors and their interaction were studied
with response surface methodology (central composite design). Each variable in the design was studied at five different levels,
with all variables taken at a central coded value of zero. Considerable amount of glucose oxidase was produced from A. niger species with sucrose as the carbon source, sodium nitrate as the inorganic nitrogen source, and peptone as the organic nitrogen
source. Glucose oxidase activity increased remarkably by 28.93 fold (from 0.00993 to 0.29 U ml−1) with CaCO3-supplemented media. The outcome of Plackett–Burman design showed CaCO3, peptone, and MgSO4 as significant parameters. Further optimization using a three-factor central composite design with 20 experiments increased
yield of glucose oxidase from 0.29 to 2.05 U ml−1 (sevenfold) with a decrease in cultivation time from 96 to 72 h. 相似文献
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Polythiophene thin films were deposited successfully on glass substrate by chemical bath deposition method using FeCl3 as an oxidant and chloroform as solvent. The effect of oxidant concentration on the properties of polythiophene thin films was studied. The surface morphology was influenced by oxidant concentration and deposition time. The oxidation concentration also strongly affects the optical properties of the polythiophene thin films. The transmittance decreases while the absorption, band gap and refractive index increases due to increase in oxidant concentration. 相似文献
28.
29.
Sandip Ghosh Chowdhury Samar Das B. Ravikumar P. K. De 《Metallurgical and Materials Transactions A》2006,37(8):2349-2359
This paper deals with the evolution of texture in AISI 316L austenitic stainless steel during annealing after 95 pct cold
rolling. After 95 pct cold rolling, the texture is mainly of the brass type {110}〈112〉, along with a scatter toward the S
orientation {123}〈634〉 and Goss orientation {011}〈100〉. Weak evidence of Cu component is observed at this high deformation
level. During annealing, recovery is observed before any detectable recrystallization. Recrystallization proceeds through
nucleation of subgrain by twinning within the deformed matrix and, later, preferential growth of those to consume the deformed
matrix. After recrystallization, the overall texture intensity was weak; however, there are some discernible texture components.
There was no existence of the brass component at this stage. Major components are centered on Goss orientation and Cu component
{112}〈111〉 as well as the BR component {236}〈385〉. Also, a few orientations come up after recrystallization (i.e., {142}〈2−11〉 and {012}〈221〉). With increase in annealing temperature, the textural evolution shows emergence of weak texture
with another new component, {197}〈211〉. The evolution of texture was correlated with the deformation texture through twin
chain reaction. 相似文献
30.
Although industrial and commercial uses of mercury have been curtailed in recent times, there is a demonstrated need for the development of reliable hazardous waste management techniques because of historic operations that have led to significant contamination and ongoing hazardous waste generation. This study was performed to evaluate whether the U.S. EPA could propose treatment and disposal alternatives to the current land disposal restriction (LDR) treatment standards for mercury. The focus of this article is on the current state of encapsulation technologies that can be used to immobilize elemental mercury, mercury-contaminated debris, and other mercury-contaminated wastes, soils, sediments, or sludges. The range of encapsulation materials used in bench-scale, pilot-scale, and full-scale applications for mercury-contaminated wastes are summarized. Several studies have been completed regarding the application of sulfur polymer stabilization/solidification, chemically bonded phosphate ceramic encapsulation, and polyethylene encapsulation. Other materials reported in the literature as under development for encapsulation use include asphalt, polyester resins, synthetic elastomers, polysiloxane, sol-gels, Dolocrete, and carbon/cement mixtures. The primary objective of these encapsulation methods is to physically immobilize the wastes to prevent contact with leaching agents such as water. However, when used for mercury-contaminated wastes, several of these methods require a pretreatment or stabilization step to chemically fix mercury into a highly insoluble form prior to encapsulation. Performance data is summarized from the testing and evaluation of various encapsulated, mercury-contaminated wastes. Future technology development and research needs are also discussed. 相似文献