高峰值功率重频脉冲固体激光器

综述了高峰值功率重频脉冲固体激光器的发展现状，对其中的Ｑ开关、腔倒空、锁模等窄脉冲技术和放大技术进行了分析，展示了高峰值功率重频脉冲固体激光器的发展前景。     

Quantitative analysis of organochlorine pesticide residues in Chinese drugs

This paper reports the GC determination of 20 organochlorine pesticides in Chinese drugs Flos Ionicerae and Moluodan etc by the present method of Japan for determinaing pesticide residues. The results suggest that except Folium Isatidis, Radix Codonopsis and Sanqi Pian all accord with the for provisions pesticide residues in Japanese foodstuffs.     

On the Realization of Current－Mode Continuous－Time Operational Transconductance Capacitance Filter

ＯｎｔｈｅＲｅａｌｉｚａｔｉｏｎｏｆＣｕｒｒｅｎｔ－ＭｏｄｅＣｏｎｔｉｎｕｏｕｓＴｉｍｅＯｐｅｒａｔｉｏｎａｌＴｒａｎｓｃｏｎｄｕｃｔａｎｃｅＣａｐａｃｉｔａｎｃｅＦｉｌｔｅｒ￥ＧｕｏＪｉｎｇｂｏａｎｄＨａｎＱｉｎｇｑｕａｎ（ＣｈａｎｇｃｈｕｎＰｏｓ...     

扑炎痛的合成新法

以水杨酸和对硝基苯酚为原料,在三氯氧磷存在下进行酯化,然后催化加氢还原硝基,最后用乙酐进行二酰化制得扑炎痛,三步收率分别为80.8％、90.4％和88.5％。     

Residues Val254, His256, and Phe259 of the angiotensin II AT1 receptor are not involved in ligand binding but participate in signal transduction

The role of the external third of helix VI of the angiotensin II (AII) AT1 receptor for the interaction with its ligand and for the subsequent signal transduction was investigated by individually replacing residues 252-256 by Ala, and residues 259 or 261 by Tyr, and permanently transfecting the resulting mutants to Chinese hamster ovary (CHO) cells. Binding experiments showed no great changes in affinity of any of the mutants for AII, [Sar1]-AII, or [Sar1, Leu8]-AII, but the affinity for the nonpeptide antagonist DuP753 was significantly decreased. The inositol phosphate response to AII was remarkably decreased in mutants V254A, H256A, and F259Y. These results indicate that AT1 residues Val254, His256, and Phe259 are not involved in ligand binding but participate in signal transduction. Based in these results and in others from the literature, it is suggested that, in addition to the His256 imidazole ring, the Phe259 aromatic ring interacts with the AII's Phe8, thus contributing to the signal-triggering mechanism.     

Selective monitoring of peptidase activities with synthetic polypeptide substrates and polyion-sensitive membrane electrode detection

A novel method to monitor specific peptidase activities in biological samples as complex as undiluted plasma/blood is described. The approach is based on the design of synthetic polypeptide substrates in which di- or triarginine sequences are linked to each other via one or more other amino acids recognized specifically by the peptidase to be determined. Detection of chymotrypsin and renin activities using synthetic substrates P4 (F-R-R-R-F-V-R-R-F-NH2) and P5 (R-R-R-L-L-R-R-L-L-R-R-R), respectively, serves to demonstrate the principles of this new assay system. A polyion-sensitive membrane electrode, prepared by doping polymer films with dinonylnaphthalene-sulfonate (DNNS), is shown to exhibit significant nonequilibrium electromotive force (EMF) responses toward these and other polycationic substrates at microgram/milliliter levels under physiological conditions. The same electrode, however, exhibits much smaller total EMF response toward the shorter fragments of the synthetic peptides generated by peptidase activity; hence, the addition of peptidase to a solution containing the synthetic substrate yields a change in electrode EMF response, the rate of which is proportional to the activity of peptidase present. Other synthetic polycationic peptides as well as natural polycationic peptides (e.g., protamine) that lack specific cleavage sites for chymotrypsin and renin, yet are detected by the DNNS-based membrane electrode, do not elicit any significant change in EMF response in the presence of the peptidases, confirming the feasibility and utility of the proposed bioanalytical method.     

低能重离子及其碰撞产生的级联原子在生物材料中的直接作用范围

用Ｍｏｎｔｅ Ｃａｒｌｏ法模拟计算了３０ｋｅＶ和２００ｋｅＶ的Ｎ＾＋与１１０ｋｅＶ的Ｆｅ＾＋在模拟细胞中的射程分布和径迹结构，并将１１０ｋｅＶＦｅ＾＋模拟计算的结果与ＲＳＢ测量的结果相比较，发现计算与测量的结果吻合较好，离子的作用范围小于１μｍ。计算和实验的结果都说明能量相当低的重离子不大可能直接作用引起麦胚深层生物效应。     

用复合烷基锂引发丁二烯聚合

对以环己烷为溶剂、四氢呋喃为微观结构调节剂、复合烷基锂为引发剂的丁二烯聚合反应过程进行了研究，考察了不同引发温度、不同配比的复合烷基锂对聚合反应的影响，并与以正丁基锂为引发剂的丁二烯聚合反应过程进行了比较。     

Initial results of an in vitro fertilization and embryo transfer program in a private health institution

Between October 1994 and the end of February 1995 115 patients were included in our programme. In these patients we monitored 141 cycles, performed 128 punctures and 100 ET. In 14 instances (9.2%) the cycle was abolished. By puncture of 1468 follicles 1370 oocytes were obtained which corresponded to a recovery rate of 93.3%. On average by aspiration 11.9 oocytes per patient were obtained. From the total number of acquired oocytes 54.6% were fertilized and 43.5% divided. Of 596 embryos 290 were transferred and the remainder was vitrified. A total of 17 clinical pregnancies were achieved, incl. 5 which terminated by abortion, the remainder proceeds. The authors are aware that they present a relatively small group during a short period of time, and thus the first results of the centre cannot be presented as a current standard. Despite this the results permit some optimism for the future and indicate a certain amount of standardization of the authors' clinical and laboratory work.