Generation of Arylated Quinones by Iron‐Catalyzed Oxidative Arylation of Phenols: Formal Synthesis of Phellodonin,Sarcodonin ε, Leucomelone and Betulinan A

Biologically and pharmaceutically relevant arylated quinones (Quin‐Ar) have been synthesized via direct C H arylation of a variety of phenols using arylboronic acids. An inexpensive, environmentally friendly iron catalyst, ferric sulphate, Fe₂(SO₄)₃, was employed in this operationally simple and efficient method.

     

Development of a production inventory model with uncertainty and reliability considerations

This paper addresses a problem of an imperfect production system under fuzzy demand and inventory holding cost. Production process reliability is considered because of the imperfect production process. In this problem, reliability of the system in regards to producing defective and non-defective items is considered as a decision variable. The objective is to maximize the graded mean integration value (GMIV) of the expected average profit while considering revenues as well as any other relevant costs. The developed model belongs to the class of a geometric programming. We have developed a simple mathematical methodology to solve the model. Genetic algorithm and simulated annealing algorithms are also applied to solve and validate the results. A numerical example has been presented to interpret the solutions.     

Constrained Efficient Global Optimization for Pultrusion Process

Composite materials, as the name indicates, are composed of different materials that yield superior performance as compared to individual components. Pultrusion is one of the most cost-effective manufacturing techniques for producing fiber-reinforced composites with constant cross-sectional profiles. This obviously makes it more attractive for both researchers and practitioners to investigate the optimum process parameters. Validated computer simulations cost less as compared to physical experiments, therefore this makes them an efficient tool for numerical optimization. However, the complexity of the numerical models can still be “expensive” and forces us to use them sparingly. These relatively more complex models can be replaced with “surrogates,” which are less complex and are therefore faster to evaluate representative models. In this article, a previously validated thermochemical simulation of the pultrusion process has shortly been presented. Following this, a new constrained optimization methodology based on a well-known surrogate method, i.e., Kriging, is introduced. Next, a validation case is presented to clarify the working principles of the implementation, which also supports the upcoming main optimization test cases. This design problem involves the design of the heating die with one, two, and three heaters together with the pulling speed. The results show that the proposed methodology is very efficient in finding the optimal process and design parameters.     

Spectroscopic study of Y210C lambda-repressor: implications for cooperative interaction

The development of a percutaneous artificial internal organ system requires a reliable biocompatible connection between the external environment and the inside of the human body. Such is necessary for the success of a permanent left ventricular assist device. However, the search for a satisfactory interface at the epidermal level has proven to be difficult. Carbon has been proposed for this application, but its texture does not typically promote ingrowth from surrounding tissue. We have therefore employed a new processing method to produce a fine trabecularized carbon implant. The method for preparing the implant involves infiltrating low temperature pyrolytic carbon into the surface of a carbon core which is wrapped with carbon fabric. This results in a tightly woven porous structure of carbon (carbon fiber diameter: 35-50 microm, maximal pore size >200 microm) with gradually increasing porosity from 15-75%. We implanted test samples percutaneously in a calf for in vivo histological evaluation. Thirty days after implantation epidermal downgrowth was minimal. Microscopic analysis revealed that a thin fibrous capsule surrounded the implant, and mature connective tissue with accompanying blood vessels filled the pores of the fine trabecularized carbon layer. From these results we suggest that fine trabecularized carbon is ideally suited for a percutaneous device system in a permanent left ventricular assist device.     

Dialogues from the land of love and death

Knowledge and action constitute two important and inter-related domains of human existence. The very pace of our modern life with all its material abundance hardly allows us space for the dawning of higher knowledge or scope for imparting deeper meaning into the endless series of our mechanical actions. The limitations of linear thinking, binary logic and specialized disciplines of knowledge prevent our access to a holistic perception of our life-world. The article draws insights from three classical traditions of learning to highlight the importance of conversations and dialogues as alternative and non-conventional sources of creating and disseminating actionable knowledge. The author delves into a depth exploration of three timeless masterpieces of world literature and philosophy for a comprehensive understanding of the drama of life and death and attempts to create a space for unconditional love in our quest of illumined knowledge and engagement in meaningful action.     

Hot-electron transport in In0.53Ga0.47As

A set of physical constants for In_0.53Ga_0.47As as required for transport calculations is obtained by reviewing the literature. Velocities for fields up to 100 kV/cm, calculated by the Monte Carlo method using these constants, are presented for the temperatures of 95 and 300 K. The calculated values are found to be in good agreement with the available experimental results.