Optimisation of maintenance strategy for rural road network using genetic algorithm

The objective of this paper is to develop an optimised maintenance strategy for the rural road network of Kerala state. This is accomplished with the development of a bi-objective deterministic optimisation model which simultaneously satisfies the objectives of both minimisation of total maintenance cost and maximisation of performance of the road network. The model is capable of planning the maintenance activities over a multi-year planning period. The performance of the road network is accounted using the composite index, namely Pavement Condition Index. The constraint-based genetic algorithm was used as the optimisation tool since it very well takes care of the combinatorial nature of the network-level pavement maintenance programming. The applicability of the model is illustrated using a case study for the rural road network of Kerala state in India. The effort made through this research work to develop a suitable Pavement Maintenance and Management System for rural road network can lead to the proper maintenance and upkeep of the rural roads, thereby triggering a positive impact on the Indian economy.     

Biohybrid Bovine Bone Matrix for Controlled Release of Mesenchymal Stem/Stromal Cell Lyosecretome: A Device for Bone Regeneration

SmartBone^® (SB) is a biohybrid bone substitute advantageously proposed as a class III medical device for bone regeneration in reconstructive surgeries (oral, maxillofacial, orthopedic, and oncology). In the present study, a new strategy to improve SB osteoinductivity was developed. SB scaffolds were loaded with lyosecretome, a freeze-dried formulation of mesenchymal stem cell (MSC)-secretome, containing proteins and extracellular vesicles (EVs). Lyosecretome-loaded SB scaffolds (SBlyo) were prepared using an absorption method. A burst release of proteins and EVs (38% and 50% after 30 min, respectively) was observed, and then proteins were released more slowly with respect to EVs, most likely because they more strongly adsorbed onto the SB surface. In vitro tests were conducted using adipose tissue-derived stromal vascular fraction (SVF) plated on SB or SBlyo. After 14 days, significant cell proliferation improvement was observed on SBlyo with respect to SB, where cells filled the cavities between the native trabeculae. On SB, on the other hand, the process was still present, but tissue formation was less organized at 60 days. On both scaffolds, cells differentiated into osteoblasts and were able to mineralize after 60 days. Nonetheless, SBlyo showed a higher expression of osteoblast markers and a higher quantity of newly formed trabeculae than SB alone. The quantification analysis of the newly formed mineralized tissue and the immunohistochemical studies demonstrated that SBlyo induces bone formation more effectively. This osteoinductive effect is likely due to the osteogenic factors present in the lyosecretome, such as fibronectin, alpha-2-macroglobulin, apolipoprotein A, and TGF-β.     

Chemical composition,sensory and cooking quality evaluation of durum wheat spaghetti enriched with pea flour

The goal of the study was to obtain spaghetti enriched with pea flour with sensory properties close to conventional pasta. To this aim, the study has been organised in two subsequent trials. In the first, the pea flour amount added to the spaghetti was continuously increased until the overall sensory quality reached its threshold value (pea flour concentration = 15%). In fact, the spaghetti samples supplemented with 15% pea flour (15%S‐P) showed less elasticity, unpleasant colour and higher firmness compared to the control sample (CTRL). The second step was aimed to improve the overall sensory quality of the 15%S‐P spaghetti by means of guar gum (GUAR). The sample with GUAR (15%S‐P/GUAR) showed a pleasant colour, odour and taste. Furthermore, the 15%S‐P/GUAR sample recorded a low starch digestibility value (i.e. 54) and a higher soluble fibre content with respect to the 15%S‐P sample.     

Reversible Fragmentation and Self‐Assembling of Nematic Liquid Crystal Droplets on Functionalized Pyroelectric Substrates

Investigation on the behavior of nematic liquid crystals on functionalized polar dielectric crystal substrates is accomplished. Very interesting effects can be observed in maneuvering liquid crystal droplets on the substrate surface, driven by electric fields generated by pyroelectric effect. Reversible drops fragmentation and self‐assembling in different configurations can be achieved. The dynamics of the observed phenomena is studied and the repeatability of the process is full assessed.     

Using bent carbon nanotubes for the fabrication of electromechanical switches

An electromechanical switch based on bent carbon nanotubes was fabricated. The shape and structure of the bent carbon nanotubes allows one to produce a low cost and low working voltage switch. The fabrication process is free of any nanolithography. The electrical characteristics of the fabricated device were investigated, both experimentally and theoretically. Actuation of the fabricated device shows hysteresis behavior in the measured I–V curves depending on the structural parameters of the bent nanotubes. The relationship between the pull-in voltage and the morphology of the bent nanotubes was studied by the obtained hysteresis curves. A scanning electron microscope was used for structural analysis. This study introduced an easy way to fabricate electromechanical switches with controllable on/off states.