Carcass measurements and meat quality characteristics of dairy suckling kids compared to an indigenous genotype

Effects of genotype on carcass measurements and meat quality were investigated by using 24 suckling kids from Turkish Saanen, Gokceada and Maltese breeds. Carcass quality characteristics of indigenous kids (Gokceada) were lower than those of dairy type (Turkish Saanen and Maltese) kids. Breed effect on ultimate meat pH, cooking loss, drip loss and Warner Bratzler shear force values were not significant. Meat samples from Turkish Saanen kids had higher redness (at 0, 1 and 24 h) and yellowness (at 24 h) values than Gokceada kids (P < 0.05). Breed had no significant effect on sensory characteristics except flavour intensity. Flavour intensity scores given to meat samples of Maltese kids were higher than those of Turkish Saanen and Gokceada kids (P < 0.01). In conclusion, dairy type breeds should be considered for meat production as well, with meat from Maltese kids potentially offering better colour and flavour intensity than that of Turkish Saanen kids.     

<Emphasis Type="Italic">I-Quest</Emphasis>: an <Emphasis Type="Italic">i</Emphasis>ntelligent <Emphasis Type="Italic">que</Emphasis>ry <Emphasis Type="Italic">st</Emphasis>ructuring based on user browsing feedback for semantic retrieval of video data

In spite of significant improvements in video data retrieval, a system has not yet been developed that can adequately respond to a user’s query. Typically, the user has to refine the query many times and view query results until eventually the expected videos are retrieved from the database. The complexity of video data and questionable query structuring by the user aggravates the retrieval process. Most previous research in this area has focused on retrieval based on low-level features. Managing imprecise queries using semantic (high-level) content is no easier than queries based on low-level features due to the absence of a proper continuous distance function. We provide a method to help users search for clips and videos of interest in video databases. The video clips are classified as interesting and uninteresting based on user browsing. The attribute values of clips are classified by commonality, presence, and frequency within each of the two groups to be used in computing the relevance of each clip to the user’s query. In this paper, we provide an intelligent query structuring system, called I-Quest, to rank clips based on user browsing feedback, where a template generation from the set of interesting and uninteresting sets is impossible or yields poor results.

GSK343, an Inhibitor of Enhancer of Zeste Homolog 2, Reduces Glioblastoma Progression through Inflammatory Process Modulation: Focus on Canonical and Non-Canonical NF-κB/IκBα Pathways

Glioblastoma (GB) is a tumor of the central nervous system characterized by high proliferation and invasiveness. The standard treatment for GB includes radiotherapy and chemotherapy; however, new therapies are needed. Particular attention was given to the role of histone methyltransferase enhancer of zeste-homolog-2 (EZH2) in GB. Recently, several EZH2-inhibitors have been developed, particularly GSK343 is well-known to regulate apoptosis and autophagy processes; however, its abilities to modulate canonical/non-canonical NF-κB/IκBα pathways or an immune response in GB have not yet been investigated. Therefore, this study investigated for the first time the effect of GSK343 on canonical/non-canonical NF-κB/IκBα pathways and the immune response, by an in vitro, in vivo and ex vivo model of GB. In vitro results demonstrated that GSK343 treatments 1, 10 and 25 μM significantly reduced GB cell viability, showing the modulation of canonical/non-canonical NF-κB/IκBα pathway activation. In vivo GSK343 reduced subcutaneous tumor mass, regulating canonical/non-canonical NF-κB/IκBα pathway activation and the levels of reactive oxygen species (ROS), malondialdehyde (MDA), and superoxide dismutase (SOD). Ex vivo results confirmed the anti-proliferative effect of GSK343 and also demonstrated its ability to regulate immune response through CXCL9, CXCL10 and CXCL11 expression in GB. Thus, GSK343 could represent a therapeutic strategy to counteract GB progression, thanks to its ability to modulate canonical/non-canonical NF-κB/IκBα pathways and immune response.