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High Reliability Organizations (HROs) are complex systems in which many accidents and adverse events that could occur within those systems or at the interfaces with other systems are actually avoided or prevented. Many organizations in high-risk industries have successfully implemented HRO approaches. In recent years, initiatives have been undertaken aimed at transforming hospitals into HROs. Actually, despite some improvements, these initiatives have not shown the expected results. In this paper, we discuss the possible reasons for such outcomes. We will show that, when compared with traditional HROs, hospitals are undoubtedly high-risk organizations, but have specificities and experience systemic socio-organizational barriers that make them difficult to transform into HROs. 相似文献
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Giuseppe Murdaca Alessandro Allegra Francesca Paladin Fabrizio Calapai Caterina Musolino Sebastiano Gangemi 《International journal of molecular sciences》2021,22(16)
Objective: Multiple Myeloma (MM) is a haematological disease resulting from the neoplastic transformation of plasma cells. The uncontrolled growth of plasma cells in the bone marrow and the delivery of several cytokines causes bone erosion that often does not regress, even in the event of disease remission. MM is characterised by a multi-step evolutionary path, which starts with an early asymptomatic stage defined as monoclonal gammopathy of undetermined significance (MGUS) evolving to overt disease. Data Sources and Study Selection: We have selected scientific publications on the specific topics “alarmis, MGUS, and MM”, drawing from PubMed. The keywords we used were alarmines, MGUS, MM, and immune system. Results: The analysis confirms the pivotal role of molecules such as high-mobility group box-1, heat shock proteins, and S100 proteins in the induction of neoangiogenesis, which represents a milestone in the negative evolution of MM as well as other haematological and non-haematological tumours. Conclusions: Modulation of the host immune system and the inhibition of neoangiogenesis may represent the therapeutic target for the treatment of MM that is capable of promoting better survival and reducing the risk of RRMM. 相似文献
176.
The industrial area of Porto Marghera discharges every year about 1.85 10(9) m(3) of waste waters in the Lagoon of Venice through its 142 discharge points, 17 of them being constantly active. The Anti-Pollution Department of Magistrato alle Acque, the Venice Water Authority, has been controlling these discharges for many years. The huge database built up during the last years could help the authorities in making choices regarding the water quality of the Venetian environment. The application of chemometric methods to the dataset obtained from chemical analyses of industrial waste water samples (almost 250, for each of them up to 57 chemical variables having been measured) is useful to answer fundamental questions related to the pollution generated by the industrial area: i) which are the main differences among the individual discharge points? ii) is there a temporal trend in global and punctual pollution? iii) which is the discharge point having the strongest relative impact on the waters? The results of the present work allow to 1) identify two different groups of discharge points, discriminated by the level of contamination and by the presence of different contaminants; 2) detect a relevant temporal trend in one of the main outfalls (the industrial and civil waste treatment plant); 3) set up a multivariate strategy to "measure" the relative modification induced on receiving lagoon waters by a single discharge. The application of such a "3-STEP multivariate analysis" to the present and future data of water quality could represent a relevant tool for monitoring industrial activities, providing at the same time a support in management decision processes. 相似文献
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Lakey Brian; McCabe Kristen M.; Fisicaro Sebastiano A.; Drew Jana Brittain 《Canadian Metallurgical Quarterly》1996,70(6):1270
The extent to which perceived social support reflects characteristics of the environment, the personality of the perceiver, and their interaction is unknown. This article shows how the methods of generalizability theory can be used to address these questions. When participants rate the same targets on the targets' supportiveness, generalizability theory provides methods for determining the extent to which support judgments are determined by effects due to targets (supporters), perceivers, and their interaction. In 3 studies, each source of variance made significant contributions to support judgments, with the Perceivers?×?Supporters interaction, characteristics of supporters, and biases of perceivers making the largest contributions, respectively. The implications for theoretical models of perceived support are discussed. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
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Daniele D. Giusto Carlo S. Regazzoni Sebastiano B. Serpico Gianni Vernazza 《电信纪事》1990,45(9-10):503-518
In this paper, we present a new approach to picture coding that integrates, in an intelligent way, some advanced techniques. The basic idea is to code by different methods the areas in a scene that are characterized by different degrees of importance. To this end, we use an understanding system that locates such areas and applies to them either vector quantization or polynomial approximation, thus fully exploiting the characteristics of methods of different generations. Results are presented for two application cases : they prove the validity of the proposed intelligent integration by showing very high performances. 相似文献
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We report optical near-field Raman imaging with subdiffraction resolution (approximately 120 nm) without field enhancement effects. Chemical discrimination on tetracyanoquinodimethane organic thin films showing localized salt complexes is accomplished by detailed Raman maps. Acquisition times that are much shorter than previously reported are due to the high Raman efficiency of the materials and to careful collection and detection of the optical signals in our near-field Raman spectrometer. 相似文献
180.
Tiziana Genovese Marika Cordaro Rosalba Siracusa Daniela Impellizzeri Sebastiano Caudullo Emanuela Raffone Francesco Macrí Livia Interdonato Enrico Gugliandolo Claudia Interlandi Rosalia Crupi Ramona DAmico Roberta Fusco Salvatore Cuzzocrea Rosanna Di Paola 《International journal of molecular sciences》2022,23(10)
Endometriosis is usually associated with inflammation and chronic pelvic pain. This paper focuses the attention on the anti-inflammatory, anti-oxidant and analgesic effects of cannabidiol (CBD) and on its potential role in endometriosis. We employed an in vivo model of endometriosis and administered CBD daily by gavage. CBD administration strongly reduced lesions diameter, volume and area. In particular, it was able to modify lesion morphology, reducing epithelial glands and stroma. CBD showed anti-oxidant effects reducing lipid peroxidation, the expression of Nox-1 and Nox-4 enzymes. CBD restored the oxidative equilibrium of the endogenous cellular defense as showed by the SOD activity and the GSH levels in the lesions. CBD also showed important antifibrotic effects as showed by the Masson trichrome staining and by downregulated expression of MMP-9, iNOS and TGF-β. CBD was able to reduce inflammation both in the harvested lesions, as showed by the increased Ikb-α and reduced COX2 cytosolic expressions and reduced NFkB nuclear localization, and in the peritoneal fluids as showed by the decreased TNF-α, PGE2 and IL-1α levels. CBD has important analgesic effects as showed by the reduced mast cells recruitment in the spinal cord and the reduced release of neuro-sensitizing and pro-inflammatory mediators. In conclusion, the collected data showed that CBD has an effective and coordinated effects in endometriosis suppression. 相似文献