The Role of Matrix Metalloproteinase in Inflammation with a Focus on Infectious Diseases

Matrix metalloproteinases (MMPs) are involved in extracellular matrix remodeling through the degradation of extracellular matrix components and are also involved in the inflammatory response by regulating the pro-inflammatory cytokines TNF-α and IL-1β. Dysregulation in the inflammatory response and changes in the extracellular matrix by MMPs are related to the development of various diseases including lung and cardiovascular diseases. Therefore, numerous studies have been conducted to understand the role of MMPs in disease pathogenesis. MMPs are involved in the pathogenesis of infectious diseases through a dysregulation of the activity and expression of MMPs. In this review, we discuss the role of MMPs in infectious diseases and inflammatory responses. Furthermore, we present the potential of MMPs as therapeutic targets in infectious diseases.     

数据驱动的航天器故障诊断研究现状及挑战

总结了基于数据驱动的故障诊断技术理论、方法及其在航天器上的应用现状,指出其面临的挑战并提出一种解决方案。将基于数据驱动的故障诊断方法按照技术发展顺序分为基于传统机器学习的方法、基于深度学习的方法以及基于迁移学习的方法。基于传统机器学习的方法需要大量的人工参与和丰富的专家经验,在小样本数据上有着优异的性能,但不适合处理大数据。在大数据背景下,重点介绍了卷积神经网络、循环神经网络、深度自编码器以及深度信念网络的基本概念以及原理,对其在航天器故障诊断领域的研究现状进行了阐述和总结。针对深度学习严重依赖于带标签数据这一问题,介绍了基于迁移学习的故障诊断技术,并提出适应航天器应用的场景,为数据驱动的故障诊断技术工程应用提供了一种方法和思路。     

Hypoxia Promotes Angiogenic Effect in Extracranial Arteriovenous Malformation Endothelial Cells

Arteriovenous malformation (AVM) is characterized by high-flow blood vessels connecting arteries and veins without capillaries. This disease shows increased angiogenesis and a pathophysiological hypoxic environment in proximal tissues. Here, we analyzed the effects of hypoxia on angiogenesis in the endothelial cells (ECs) of AVM and normal tissues. ECs from human normal and AVM tissues were evaluated using immunocytochemistry with CD31. In vitro tube formation under hypoxia was tested in both ECs using Matrigel. The relative expression of angiogenesis-related genes was measured using real-time PCR. Under normoxia, CD31 was significantly higher in AVM ECs (79.23 ± 0.65%) than in normal ECs (74.15 ± 0.70%). Similar results were observed under hypoxia in AVM ECs (63.85 ± 1.84%) and normal ECs (60.52 ± 0.51%). In the tube formation test under normoxic and hypoxic conditions, the junction count and total vessel length were significantly greater in AVM ECs than normal ECs. Under both normoxia and hypoxia, the angiogenesis-related gene FSTL1 showed a significantly higher expression in AVM ECs than in normal ECs. Under hypoxia, CSPG4 expression was significantly lower in AVM ECs than in normal ECs. Accordingly, the angiogenic effect was increased in AVM ECs compared with that in normal ECs. These results provide a basic knowledge for an AVM treatment strategy.     

Estimation of fracture density and orientation from azimuthal elastic impedance difference through singular value decomposition

Accurate estimation of fracture density and orientation is of great significance for seismic character-ization of fractured reservoirs.Here,we propose a novel m...     

美国声波钻进规程ASTM D6914/D6914M-16浅析

声波钻进技术具有速度快、岩心保真好、适用地层广等优点,广泛应用于工程勘察、环境调查、浅源地热、基础工程、矿山治理等领域.为了提高声波钻进施工质量和过程控制,美国材料与实验协会于2004年制定了第一部声波钻进规程D6914-04,后经多次修订完善,形成最新声波钻进规程D6914/D6914M-16.本文根据该版规程内容,从技术原理、钻进设备、成孔工艺等方面展开了阐述.当振动器与钻柱谐振频率重叠时,声波钻头受到的能量达到峰值.钻机和取心钻具是声波钻进的核心设备.成孔工艺主要以双管高频振动、低速回转为主,实现多种目的层的原位取心作业.标准相关内容对声波钻进技术在我国的持续推广具有参考意义.     

基于BIM理念的绿色建筑新思维

通过BIM精细化设计, 使用统一的数据源, 保持整个设计过程数据的可持续性, 对设计各阶段进行优化, 使设计作品达到绿色建筑设计的要求。此外, 使用数字模拟软件Ecotect、Fluent、Abaqus、Pathfinder等对光照、风环境、荷载、人员疏散进行模拟分析, 并通过模拟结果来优化建筑开窗、建筑遮阳、建筑抗震、建筑疏散以及可再生能源的利用, 提升设计质量, 保证设计的安全性、节能性、环保性和可持续性, 使图书馆具有更适合学习和生活的室内外环境, 达到“人-建筑-自然”三者和谐共生。     

葡萄梗(茎)中的生物活性物质研究现状

葡萄梗(茎)是葡萄加工业副产物之一,富含高附加值的生物活性成分,可用于食品、医药和化妆品等工业领域,但较少被人们关注和开发。本文介绍了葡萄梗(茎)中生物活性物质的分布和分离纯化的研究现状,旨在为葡萄生产废弃物葡萄梗(茎)的综合利用提供一定的参考和借鉴。      

利用视觉目标遮挡和轮廓信息确定下一最佳观测方位

下一最佳观测方位的确定是视觉领域一个比较困难的问题。该文提出一种基于视觉目标深度图像利用遮挡和轮廓信息确定下一最佳观测方位的方法。该方法首先对当前观测方位下获取的视觉目标深度图像进行遮挡检测。其次根据深度图像遮挡检测结果和视觉目标轮廓构建未知区域,并采用类三角剖分方式对各未知区域进行建模。然后根据建模所得的各小三角形的中点、法向量、面积等信息构造目标函数。最后通过对目标函数的优化求解得到下一最佳观测方位。实验结果表明所提方法可行且有效。