Macrosegregation during dendritic arrayed growth of hypoeutectic pb- sn alloys: Influence of primary arm spacing and mushy zone length

Thermosolutal convection in the dendritic mushy zone occurs during directional solidification of hypoeutectic lead tin alloys in a positive thermal gradient, with the melt on the top and the solid below. This results in macrosegregation along the length of the solidified samples. The extent of macrosegregation increases with increasing primary dendrite spacings for constant mushy zone length. For constant primary spacings, the macrosegregation increases with decreasing mushy zone length. Presence of convection reduces the primary dendrite spacings. However, convection in the interdendritic melt has significantly more influence on the spacings as compared with that in the overlying melt, which is caused by the solutal buildup at the dendrite tips. Formerly Graduate Student, Chemical Engineering Department, Cleveland State University     

Effect of supplemental oxygen on supramaximal exercise performance and recovery in cystic fibrosis

The effects of supplemental O2 on recovery from supramaximal exercise and subsequent performance remain unknown. If recovery from exercise could be enhanced in individuals with chronic lung disease, subsequent supramaximal exercise performance could also be improved. Recovery from supramaximal exercise and subsequent supramaximal exercise performance were assessed after 10 min of breathing 100% O2 or room air (RA) in 17 cystic fibrosis (CF) patients [25 +/- 10 (SD) yr old, 53% men, forced expired volume in 1 s = 62 +/- 21% predicted] and 17 normal subjects (25 +/- 8 yr old, 59% men, forced expired volume in 1 s = 112 +/- 15% predicted). Supramaximal performance was assessed as the work of sustained bicycling at a load of 130% of the maximum load achieved during a graded maximal exercise. Peak minute ventilation (VE) and heart rate (HR) were lower in CF patients at the end of each supramaximal bout than in controls. In CF patients, single-exponential time decay constants indicated faster recovery of HR (tau HR = 86 +/- 8 and 73 +/- 6 s in RA and O2, respectively, P < 0.01). Similarly, fast and slow time constants of two-exponential equations providing the best fit for ventilatory recovery were improved in CF patients during O2 breathing (tau 1VE = 132.1 +/- 10.5 vs. 82.5 +/- 10.4 s; tau 2VE = 880.3 +/- 300.1 vs. 368.6 +/- 107.1 s, P < 0.01). However, no such improvements occurred in controls. Supramaximal performance after O2 improved in CF patients (109 +/- 6% of the 1st bout after O2 vs. 94 +/- 6% in RA, P < 0.01). O2 supplementation had no effect on subsequent performance in controls (97 +/- 3% in O2 vs. 93 +/- 3% in RA). We conclude that supplemental O2 after a short bout of supramaximal exercise accelerates recovery and preserves subsequent supramaximal performance in patients with CF.     

Current mode biquadratic filter realizations employing operational amplifiers

New circuit configurations for realizing current mode biquadratic filter sections using operational amplifiers are presented. Each circuit uses a single operational amplifier and seven passive elements at most. The merits and demerits of the proposed realizations are discussed.     

Cyclic motion detection for motion based recognition

The motion of a walking person is analyzed by examining cycles in the movement. Cycles are detected using autocorrelation and Fourier transform techniques of the smoothed spatio-temporal curvature function of trajectories created by specific points on the object as it performs cyclic motion. A large impulse in the Fourier magnitude plot indicates the frequency at which cycles are occurring. Both synthetically generated and real walking sequences are analyzed for cyclic motion. The real sequences are then used in a motion based recognition application in which one complete cycle is stored as a model, and a matching process is performed using one cycle of an input trajectory.     

Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis

BACKGROUND & AIMS: Membrane lymphotoxin (LT) alpha/beta, a member of the tumor necrosis factor (TNF) family of immune regulatory molecules, is involved both in the development of secondary lymphoid tissues and the maintenance of organized lymphoid tissues in the adult. Defects observed in the mucosal immune system in animals with a genetically disrupted LTalpha/beta pathway coupled with the expression of LTalpha/beta in activated T cells motivated an examination of the importance of this pathway in experimental colitis. METHODS: Soluble LTbeta receptor (LTbetaR) immunoglobulin fusion protein was used to inhibit the LTalpha/beta/light axis in two independent rodent models of colitis: CD45RBhi CD4(+)-reconstituted SCID mice and bone marrow-transplanted tg26 mice (BM --> tg26). RESULTS: Treatment with LTbetaR immunoglobulin attenuated the development of both the clinical and histological manifestations of the disease in these two murine models of colitis. Given the success of TNF inhibitors in the treatment of human Crohn's disease, the effects of LTbetaR immunoglobulin have been compared with antibody to TNF in the BM --> tg26 model, and both treatments were equally efficacious. CONCLUSIONS: The LT pathway plays a role in the development of colitis as important as that of the TNF system and, therefore, represents a potential novel intervention point for the treatment of inflammatory bowel disease.     

Expert system approach in design of mechanical components

The present investigation is aimed toward the development of knowledge-based aids for the design of mechanical systems. We have developed and implemented the knowledgebased aid system, which includes MEET and DPMED. The basic approach of MEET follows along the lines ofDesign=Refinement+ Constraint Propagation. This approach has been proven successful in the circuit design domain. Our attempts to utilize MEET have convinced us that we need to extend this methodology to solve mechanical design problems. The DPMED methodology has been applied to design gear-pairs, v-belts, bearings, and shafts. Rules for selecting materials, critical design criteria, and so on are incorporated as part of the rule-system. In order for DPMED to select the design parameter values within the feasible design space, design criteria need to be investigated. Based on these criteria and input/output specifications, DPMED attempts to perform parameter selections. DPMED uses a general hill-climbing algorithm to guide the search.