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71.
Silicon - Silicon (Si) is very effective in the amelioration of heavy metal (HM) stress in different crop plants. This investigation was conducted to assess the protective role of Si in modulating... 相似文献
72.
73.
Asmaa Anwar Ismail Baraah Tariq Shaker Khalid Bajou 《International journal of molecular sciences》2022,23(1)
Angiogenesis is a process associated with the migration and proliferation of endothelial cells (EC) to form new blood vessels. It is involved in various physiological and pathophysiological conditions and is controlled by a wide range of proangiogenic and antiangiogenic molecules. The plasminogen activator–plasmin system plays a major role in the extracellular matrix remodeling process necessary for angiogenesis. Urokinase/tissue-type plasminogen activators (uPA/tPA) convert plasminogen into the active enzyme plasmin, which in turn activates matrix metalloproteinases and degrades the extracellular matrix releasing growth factors and proangiogenic molecules such as the vascular endothelial growth factor (VEGF-A). The plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of uPA and tPA, thereby an inhibitor of pericellular proteolysis and intravascular fibrinolysis, respectively. Paradoxically, PAI-1, which is expressed by EC during angiogenesis, is elevated in several cancers and is found to promote angiogenesis by regulating plasmin-mediated proteolysis and by promoting cellular migration through vitronectin. The urokinase-type plasminogen activator receptor (uPAR) also induces EC cellular migration during angiogenesis via interacting with signaling partners. Understanding the molecular functions of the plasminogen activator plasmin system and targeting angiogenesis via blocking serine proteases or their interactions with other molecules is one of the major therapeutic strategies scientists have been attracted to in controlling tumor growth and other pathological conditions characterized by neovascularization. 相似文献
74.
Sana Ghayas Muhammad Harris Shoaib Faaiza Qazi Rabia Bushra Fatima Ramzan Ali Madiha Maboos Farah Khalid 《Polymer Bulletin》2020,77(3):1281-1306
This work is based on formulating and optimizing controlled release (CR) valsartan (160 mg) tablets using different viscosity grades of the cellulosic polymer. The objective was to develop an effective once-daily drug delivery system of this cardiovascular agent. Central composite design was used for designing the formulations. Polymers used were Methocel® K4M, K15M and K100M. Compatibility of excipients with active was studied through FT-IR. Micromeritic properties were determined and formulations exhibiting appropriate flow characteristics were compressed. Swelling behavior and in vitro buoyancy effect were studied and response surface curves were constructed to optimize the formulation. Multi-point dissolution profiles of valsartan CR tablets at pH 1.2, 4.5 and 6.8 were obtained. Model-dependent and model-independent methods were performed including f2, stability test as per ICH guidelines and ANOVA. FT-IR studies revealed the compatibility of valsartan with all excipients. Formulation K4T9 (containing 25% K4M polymer) was selected to be the best optimized trial, based on physical properties and controlled release profile (23% at 4 h, 82% at 16 h and 100% at 24 h). Results of buoyancy and swelling behavior indicated that HPMC-K4M polymer exhibited excellent floating lag time and swelling indexes. In vitro drug release kinetics showed that formulation K4T9 displayed Korsmeyer–Peppas drug release pattern with r value > 0.99. The manufacturing process of K4T9 was also found to be reproducible with a shelf life period of 41 and 36 months at room temperature and accelerated conditions, respectively. Valsartan CR matrix-based formulation was successfully prepared with Methocel K4M retardant. 相似文献
75.
Syed Safdar Ali Khalid Mohammed Khan Hartmut Echner Wolfgang Voelter Mashooda Hasan Atta-ur-Rahman 《Advanced Synthesis \u0026amp; Catalysis》1995,337(1):12-17
Two new synthons, Fmoc-L-Arg(biphenyl-4-sulphonyl)-OH ( 8 ) and Fmoc-Arg(4-methoxy-3-t-butylbenzenesulphonyl)-OH ( 14 ), are prepared for the synthesis of arginine-containing peptides. These groups are cleaved by commonly employed trifluoroacetic acid and methanesulphonic acid. Kinetic studies reveal that extended bicyclic aromatic conjugation, as in biphenyl, slightly improves the acid lability compared to the electron-donating t-butyl group. 相似文献
76.
Amjad Ali Sartaj Ali Long Yu Hongsheng Liu Saud Khalid Azhar Hussain Mir Muhmmad Nasir Qayum Chen Ying 《应用聚合物科学杂志》2019,136(38):47978
Starch-based biodegradable films were prepared by using solution-casting method and reinforced by agricultural residues [apricot and walnut shell (APS and WNS) powder]. The powder of both shells was added in different ratios (0, 2.5, 5, 7.5, and 10%) to investigate the microstructures and performances (mechanical and thermal properties) of the starch-based film. Different techniques such as impact, tensile testing, scanning electron microscope, optical microscope (OM), X-ray diffraction (XRD), water vapor transmission rate (WVTR), and dynamic mechanical analysis were applied to study the thermomechanical and barrier properties of the composite films. Results showed that the incorporation of both shells significantly improved the WVTR and mechanical properties of starch-based films. The shells powder was significantly increased the Young's modulus and tensile strength of the starch-based films. Both OM and SEM results showed reasonably good compatibility between starch and reinforced shells. OM and XRD indicated that the APS and WNS not only retained their crystalline structure in the film but they also strengthened the peak intensity of the film. This phenomenon can be used to explain the mechanism of mechanical reinforcement. Since all the components used in the preparation of the films are food grade ingredients, it is expected that the films developed in this work will be used for food packaging applications. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 47978. 相似文献
77.
Multiwalled carbon nanotube/polycaprolactone nanocomposites (MWNT/PCL) were prepared by in situ polymerization, whereby as‐received MWNTs (P‐MWNTs) and purified MWNTs (A‐MWNTs) were used as reinforcing materials. The A‐MWNTs were purified by nitric acid treatment, which introduced the carboxyl groups (COOH) on the MWNT. The micrographs of the fractured surfaces of the nanocomposites showed that the A‐MWNTs in A‐MWNT/PCL were better dispersed than P‐MWNTs in PCL matrix (P‐MWNT/PCL). Percolation thresholds of the P‐MWNT/PCL and A‐MWNT/PCL, which were studied by rheological properties, were found at ~2 wt % of the MWNT. The conductivity of the P‐MWNT/PCL was between 10?1 and 10?2 S/cm by loading of 2 wt % of MWNT although that of the A‐MWNT/PCL reached ~10?2 S/cm by loading of 7 wt % of MWNT. The conductivity of the P‐MWNT/PCL was higher than that of the A‐MWNT/PCL at the entire range of the studied MWNT loading, which might be due to the destruction of π‐network of the MWNT by acid treatment, although the A‐MWNT/PCL was better dispersed than the P‐MWNT/PCL. The amount of the MWNT at which the conductivity of the nanocomposite started to increase was strongly correlated with the percolation threshold. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 104: 1957–1963, 2007 相似文献
78.
Rachid Essehli Brahim El BaliSaid Benmokhtar Khalid BouzianeBouchaib Manoun Mouner Ahmed AbdalslamHelmut Ehrenberg 《Journal of Alloys and Compounds》2011,509(4):1163-1171
Crystal structures from two new phosphates Na4NiFe(PO4)3 (I) and Na2Ni2Fe(PO4)3 (II) have been determined by single crystal X-ray diffraction analysis. Compound (I) crystallizes in a rhombohedral system (S. G: R-3c, Z = 6, a = 8.7350(9) Å, c = 21.643(4) Å, R1 = 0.041, wR2=0.120). Compound (II) crystallizes in a monoclinic system (S. G: C2/c, Z = 4, a = 11.729(7) Å, b = 12.433(5) Å, c = 6.431(2) Å, β = 113.66(4)°, R1 = 0.043, wR2=0.111). The three-dimensional structure of (I) is closely related to the Nasicon structural type, consisting of corner sharing [(Ni/Fe)O6] octahedra and [PO4] tetrahedra forming [NiFe(PO4)3]4+ units which align in chains along the c-axis. The Na+ cations fill up trigonal antiprismatic sites within these chains. The crystal structure of (II) belongs to the alluaudite type. Its open framework results from [Ni2O10] units of edge-sharing [NiO6] octahedra, which alternate with [FeO6] octahedra that form infinite chains. Coordination of these chains yields two distinct tunnels in which site Na+.The magnetization data of compound (I) reveal antiferromagnetic (AFM) interactions by the onset of deviations from a Curie-Weiss behaviour at low temperature as confirmed by Mössbauer measurements performed at 4.2 K. The corresponding temperature dependence of the reciprocal susceptibility χ−1 follows a typical Curie-Weiss behaviour for T > 105 K. A canted AFM state is proposed for compound (II) below 46 K with a field-induced magnetic transition at H ≈ 19 kOe, revealed in the hysteresis loop measured at 5 K. This transition is most probably associated with a spin-flop transition. 相似文献
79.
Khalid Al-Anezi Chris Somerfield David Mee Nick Hankins Nidal Hilal 《Desalination》2008,227(1-3):46-56
The objective of this work is to present experimental data that would show the effect of temperature, salinity, pressure and the presence of anti-scale additives on CO2 solubility in seawater. The paper examines the solubility of CO2 in real seawater and real seawater dosed with two different anti-scale additives. The study has been performed at temperatures between 60ºC and 90ºC and at pressures of 1 and 2 bar. To assess the effect of each anti-scale additive on CO2 gas solubility varying doses, 2–10 ppm of anti-scale additive have been used. For the purpose of the experimentation an experimental rig has been designed to ensure adequate contact between the gas phase and the aqueous phase. The continuous quantitative analysis of CO2 concentration flowing from the experimental rig was measured using a CM-5011 Carbon Coulometer. A mass balance was carried out to calculate the amount of CO2 absorbed into solution; Henry’s law constant was then calculated. 相似文献
80.
Synthesis of Novel Series of Benzothieno [2,3-d] Pyrimidine Derivatives, Promising Anticancer Agents
Omer Khalid AI-Duaij Hend Nagah Hafez Abdel-Rhman Barakat Ahmed EI-Gazzar 《化学与化工:英文版》2013,(8):725-742
An extension of the authors' previous discovery of in vitro antitumor activity of substituted thino [2,3-d] prymidine derivatives is reported. The synthesis of some new spirothino [2,3-d] prymidine (4a-f), imidazolidin, substituted prymidinyl and substituted thiazolidine thino [2,3-d] prymidine derivatives have been described. Thirteen of the obtained compounds were selected by the NCI and evaluated for their in vitro anticancer activity. Seven of the investigated compounds, 4a, 8a, 9a, (12a, b), 14a and 15a, displayed high anticancer activity in the primary assay. These compounds have been selected for a full anticancer screening against a 60-cell panel assay where they showed non-selective broad spectrum and promising activity against all cancer cell lines. Compounds 12a and 12b proved to be the active members in this study compared to 5-fluorouracil and cyclophosphamide as reference drugs, respectively. Compounds 12a and 12b were identified as promising lead compounds, evaluated for their in-vitro antitumor activity. 相似文献